FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1876770186> ?p ?o ?g. }

• W1876770186 endingPage "806" @default.
• W1876770186 startingPage "797" @default.
• W1876770186 abstract "To determine the dose-response relationship for prophylactic cranial irradiation (PCI) in small cell lung cancer, to quantify the growth kinetics of subclinical metastases, and to determine the influence of time-delay in initiating PCI on its utility.Published reports of brain relapse rates in small cell lung cancer with and without PCI were collected. The reduction in brain relapse rate as a function of radiation dose was analyzed. The time interval between treatment of the primary tumor and the initiation of PCI was analyzed as a factor potentially influencing dose-response.A shallow dose-response curve without any threshold in the dose intercept was demonstrated for control of subclinical brain metastases in early PCI (delay between initiation of treatment for primary tumor and PCI less than 60 days). By contrast late PCI (delay over 60 days) was associated with a significant displacement of the dose intercept. Doses over 30-35 Gy in 2-Gy fractions did not result in a further reduction in brain relapse rate, but there were too few high-dose studies to draw any definite conclusion.The nearly linear dose-response relationship for reduction in brain relapses demonstrated for early PCI in the range of doses from zero up to 35 Gy given in 2-Gy fractions supports the model of a fairly logarithmically uniform distribution of metastatic cell number within a series of patients. When PCI is delayed, a significant threshold in dose-response was observed, consistent with a fast growth rate of untreated subclinical brain metastases from small cell lung cancer. The exact shape and locations of dose-response curves is not well established by this retrospective analysis of diverse data. A high probability of eliminating brain relapses following PCI requires a dose of about 30-35 Gy in 2-Gy fractions. Control rates in brain can be enhanced if PCI is applied early." @default.
• W1876770186 created "2016-06-24" @default.
• W1876770186 creator A5037854143 @default.
• W1876770186 creator A5056954557 @default.
• W1876770186 creator A5091483210 @default.
• W1876770186 date "1998-03-01" @default.
• W1876770186 modified "2023-10-18" @default.
• W1876770186 title "Dose–Response Relationship for Prophylactic Cranial Irradiation in Small Cell Lung Cancer" @default.
• W1876770186 cites W1480091719 @default.
• W1876770186 cites W1544275924 @default.
• W1876770186 cites W155247356 @default.
• W1876770186 cites W1775693949 @default.
• W1876770186 cites W1827086524 @default.
• W1876770186 cites W1885320430 @default.
• W1876770186 cites W1935482218 @default.
• W1876770186 cites W1945129735 @default.
• W1876770186 cites W1973865448 @default.
• W1876770186 cites W1974262012 @default.
• W1876770186 cites W1976276185 @default.
• W1876770186 cites W1977154928 @default.
• W1876770186 cites W1981168861 @default.
• W1876770186 cites W1981461105 @default.
• W1876770186 cites W1982203825 @default.
• W1876770186 cites W1995571404 @default.
• W1876770186 cites W1995606594 @default.
• W1876770186 cites W1999280354 @default.
• W1876770186 cites W2001025782 @default.
• W1876770186 cites W2003235829 @default.
• W1876770186 cites W2008118429 @default.
• W1876770186 cites W2010578725 @default.
• W1876770186 cites W2014724682 @default.
• W1876770186 cites W2015096497 @default.
• W1876770186 cites W2018928207 @default.
• W1876770186 cites W2022438822 @default.
• W1876770186 cites W2046886248 @default.
• W1876770186 cites W2047985326 @default.
• W1876770186 cites W2050377134 @default.
• W1876770186 cites W2066923265 @default.
• W1876770186 cites W2069787488 @default.
• W1876770186 cites W2070645346 @default.
• W1876770186 cites W2071451577 @default.
• W1876770186 cites W2071733976 @default.
• W1876770186 cites W2072727198 @default.
• W1876770186 cites W2074763624 @default.
• W1876770186 cites W2079013357 @default.
• W1876770186 cites W2084638095 @default.
• W1876770186 cites W2086266302 @default.
• W1876770186 cites W2089016789 @default.
• W1876770186 cites W2096515150 @default.
• W1876770186 cites W2102835965 @default.
• W1876770186 cites W2118663808 @default.
• W1876770186 cites W2121624379 @default.
• W1876770186 cites W2124353451 @default.
• W1876770186 cites W2132003688 @default.
• W1876770186 cites W2158034304 @default.
• W1876770186 cites W2164306710 @default.
• W1876770186 cites W2217024456 @default.
• W1876770186 cites W2266309889 @default.
• W1876770186 cites W2398827560 @default.
• W1876770186 cites W2405391497 @default.
• W1876770186 cites W2410851489 @default.
• W1876770186 cites W2412914390 @default.
• W1876770186 cites W2415522930 @default.
• W1876770186 cites W2415931365 @default.
• W1876770186 cites W2416746036 @default.
• W1876770186 cites W2466468110 @default.
• W1876770186 cites W2474970446 @default.
• W1876770186 cites W3152427583 @default.
• W1876770186 cites W55740522 @default.
• W1876770186 doi "https://doi.org/10.1016/s0360-3016(97)00856-0" @default.
• W1876770186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9531363" @default.
• W1876770186 hasPublicationYear "1998" @default.
• W1876770186 type Work @default.
• W1876770186 sameAs 1876770186 @default.
• W1876770186 citedByCount "70" @default.
• W1876770186 countsByYear W18767701862012 @default.
• W1876770186 countsByYear W18767701862014 @default.
• W1876770186 countsByYear W18767701862015 @default.
• W1876770186 countsByYear W18767701862016 @default.
• W1876770186 countsByYear W18767701862017 @default.
• W1876770186 countsByYear W18767701862018 @default.
• W1876770186 countsByYear W18767701862020 @default.
• W1876770186 countsByYear W18767701862021 @default.
• W1876770186 countsByYear W18767701862022 @default.
• W1876770186 crossrefType "journal-article" @default.
• W1876770186 hasAuthorship W1876770186A5037854143 @default.
• W1876770186 hasAuthorship W1876770186A5056954557 @default.
• W1876770186 hasAuthorship W1876770186A5091483210 @default.
• W1876770186 hasConcept C113280763 @default.
• W1876770186 hasConcept C121608353 @default.
• W1876770186 hasConcept C126322002 @default.
• W1876770186 hasConcept C143998085 @default.
• W1876770186 hasConcept C2776256026 @default.
• W1876770186 hasConcept C2777714996 @default.
• W1876770186 hasConcept C2779562246 @default.
• W1876770186 hasConcept C2989005 @default.
• W1876770186 hasConcept C45393284 @default.
• W1876770186 hasConcept C500558357 @default.

• next