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- W187680792 abstract "Recent advances in biotechnology and the pharmaceutical sciences have greatly expanded the number of drugs that are being developed for the treatment of central nervous system (CNS) diseases. These drugs include a wide array of antibody, protein, peptide, and recombinant DNA agents as well as novel small agents (e. g., amino acids, nucleic acid precursors, and receptor agonists or blockers) for the treatment of brain tumors, strokes, infections, and neurodegenerative diseases. Though such agents often show excellent activity in vitro, many exhibit only restricted activity in vivo because of poor brain uptake and penetration. This problem has stimulated new work on factors that control drug uptake into brain and on methods to enhance CNS drug delivery." @default.
- W187680792 created "2016-06-24" @default.
- W187680792 creator A5008184987 @default.
- W187680792 date "1996-01-01" @default.
- W187680792 modified "2023-10-10" @default.
- W187680792 title "Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System" @default.
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- W187680792 doi "https://doi.org/10.1007/978-1-4899-1863-5_15" @default.
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