Matches in SemOpenAlex for { <https://semopenalex.org/work/W1877230721> ?p ?o ?g. }
- W1877230721 endingPage "20150009" @default.
- W1877230721 startingPage "20150009" @default.
- W1877230721 abstract "In the past decade, and pointing onwards to the immediate future, clinical radiotherapy has undergone considerable developments, essentially including technological advances to sculpt radiation delivery, the demonstration of the benefit of adding concomitant cytotoxic agents to radiotherapy for a range of tumour types and, intriguingly, the increasing integration of targeted therapeutics for biological optimization of radiation effects. Recent molecular and imaging insights into radiobiology will provide a unique opportunity for rational patient treatment, enabling the parallel design of next-generation trials that formally examine the therapeutic outcome of adding targeted drugs to radiation, together with the critically important assessment of radiation volume and dose-limiting treatment toxicities. In considering the use of systemic agents with presumed radiosensitizing activity, this may also include the identification of molecular, metabolic and imaging markers of treatment response and tolerability, and will need particular attention on patient eligibility. In addition to providing an overview of clinical biomarker studies relevant for personalized radiotherapy, this communication will highlight principles in addressing clinical evaluation of combined-modality-targeted therapeutics and radiation. The increasing number of translational studies that bridge large-scale omics sciences with quality-assured phenomics end points-given the imperative development of open-source data repositories to allow investigators the access to the complex data sets-will enable radiation oncology to continue to position itself with the highest level of evidence within existing clinical practice." @default.
- W1877230721 created "2016-06-24" @default.
- W1877230721 creator A5053482931 @default.
- W1877230721 creator A5067832352 @default.
- W1877230721 date "2015-07-01" @default.
- W1877230721 modified "2023-09-27" @default.
- W1877230721 title "Personalized radiotherapy: concepts, biomarkers and trial design" @default.
- W1877230721 cites W14844292 @default.
- W1877230721 cites W1667546620 @default.
- W1877230721 cites W1964254408 @default.
- W1877230721 cites W1967202761 @default.
- W1877230721 cites W1967358484 @default.
- W1877230721 cites W1967746415 @default.
- W1877230721 cites W1968094379 @default.
- W1877230721 cites W1968626722 @default.
- W1877230721 cites W1969772201 @default.
- W1877230721 cites W1970744454 @default.
- W1877230721 cites W1971855933 @default.
- W1877230721 cites W1972387603 @default.
- W1877230721 cites W1975114208 @default.
- W1877230721 cites W1976971060 @default.
- W1877230721 cites W1980810464 @default.
- W1877230721 cites W1985573007 @default.
- W1877230721 cites W1986351585 @default.
- W1877230721 cites W1989660002 @default.
- W1877230721 cites W1990377801 @default.
- W1877230721 cites W1996780398 @default.
- W1877230721 cites W2004271709 @default.
- W1877230721 cites W2005821722 @default.
- W1877230721 cites W2005895632 @default.
- W1877230721 cites W2006988918 @default.
- W1877230721 cites W2008535740 @default.
- W1877230721 cites W2009215680 @default.
- W1877230721 cites W2009754997 @default.
- W1877230721 cites W2010112233 @default.
- W1877230721 cites W2011403845 @default.
- W1877230721 cites W2012012103 @default.
- W1877230721 cites W2014478946 @default.
- W1877230721 cites W2014610710 @default.
- W1877230721 cites W2016052287 @default.
- W1877230721 cites W2019597341 @default.
- W1877230721 cites W2022342238 @default.
- W1877230721 cites W2026511819 @default.
- W1877230721 cites W2026576427 @default.
- W1877230721 cites W2029757766 @default.
- W1877230721 cites W2033085289 @default.
- W1877230721 cites W2034018624 @default.
- W1877230721 cites W2034646939 @default.
- W1877230721 cites W2041294219 @default.
- W1877230721 cites W2042183844 @default.
- W1877230721 cites W2045146264 @default.
- W1877230721 cites W2046875691 @default.
- W1877230721 cites W2047262695 @default.
- W1877230721 cites W2054471320 @default.
- W1877230721 cites W2055827464 @default.
- W1877230721 cites W2059246878 @default.
- W1877230721 cites W2059300459 @default.
- W1877230721 cites W2060653243 @default.
- W1877230721 cites W2064828469 @default.
- W1877230721 cites W2066091798 @default.
- W1877230721 cites W2066210329 @default.
- W1877230721 cites W2069223172 @default.
- W1877230721 cites W2074629894 @default.
- W1877230721 cites W2076451076 @default.
- W1877230721 cites W2081101007 @default.
- W1877230721 cites W2083370412 @default.
- W1877230721 cites W2083875981 @default.
- W1877230721 cites W2084116712 @default.
- W1877230721 cites W2084548139 @default.
- W1877230721 cites W2086382109 @default.
- W1877230721 cites W2086979653 @default.
- W1877230721 cites W2091372427 @default.
- W1877230721 cites W2091935484 @default.
- W1877230721 cites W2092016994 @default.
- W1877230721 cites W2094713961 @default.
- W1877230721 cites W2094847705 @default.
- W1877230721 cites W2095122653 @default.
- W1877230721 cites W2096081459 @default.
- W1877230721 cites W2097475056 @default.
- W1877230721 cites W2100065311 @default.
- W1877230721 cites W2100241851 @default.
- W1877230721 cites W2101191739 @default.
- W1877230721 cites W2101321204 @default.
- W1877230721 cites W2102650381 @default.
- W1877230721 cites W2109707815 @default.
- W1877230721 cites W2111285159 @default.
- W1877230721 cites W2115499099 @default.
- W1877230721 cites W2115726304 @default.
- W1877230721 cites W2116347275 @default.
- W1877230721 cites W2117191010 @default.
- W1877230721 cites W2118477388 @default.
- W1877230721 cites W2121274101 @default.
- W1877230721 cites W2124175402 @default.
- W1877230721 cites W2125828967 @default.
- W1877230721 cites W2128625986 @default.
- W1877230721 cites W2128739912 @default.
- W1877230721 cites W2130192128 @default.
- W1877230721 cites W2134024251 @default.