FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1877310504> ?p ?o ?g. }

• W1877310504 endingPage "92" @default.
• W1877310504 startingPage "83" @default.
• W1877310504 abstract "Previous studies have debated the notion that low blood pressure (BP) during treatment, particularly diastolic (DBP), is associated with increased risk of cardiovascular disease. We evaluated the impact of low BP on cardiovascular outcomes in a high-risk population of 15,244 hypertensive patients, almost half of whom had a history of coronary artery disease (CAD). In the prospective Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial, patients were randomized to valsartan or amlodipine regimens and followed for 4.2 years (mean) with no difference in the primary cardiovascular endpoint. A Cox proportional hazards model was used to evaluate the relationship between average on-treatment BP and clinical outcomes. The relationship between BP and cardiovascular events was adjusted for age, gender and body mass index, and baseline qualifying risk factors and diseases (smoking, high total cholesterol, diabetes mellitus, proteinuria, CAD, previous stroke and left ventricular hypertrophy). DBP ≥ 90 mmHg, compared with < 90 mmHg, was associated with increased incidence of the primary cardiovascular endpoint (all cardiac events); however, DBP < 70 mmHg, compared with ≥ 70 mmHg, was not associated with increased incidence after covariate adjustment (no J-shaped curve). Similar results were observed for death, myocardial infarction (MI), heart failure and stroke, considered separately. Nadir for MI was at DBP of 76 mmHg and for stroke 60 mmHg. The ratio of MI to stroke increased with lower DBP. In CAD patients the MI to stroke ratio was more pronounced than in patients without CAD but there was no significant J-curve in either group. Systolic BP ≥ 150 but not < 130 mmHg, compared with 130–149 mmHg, similarly was associated with increased risk for primary outcome. In conclusion, patients in BP strata ≥ 150/90 mmHg, but not patients in BP strata < 130/70 mmHg, were at increased risk for adverse outcomes in this hypertensive, high-risk population. Although benefit in preventing MI in relation to preventing stroke levels off for the lowest BPs, these data provide no support for a J-curve in the treatment of high-risk hypertensive patients . The increase in the ratio of MI to stroke with lower DBP indicates target organ heterogeneity in that the optimal on-treatment DBP for cerebroprotection is below that for cardioprotection." @default.
• W1877310504 created "2016-06-24" @default.
• W1877310504 creator A5000524196 @default.
• W1877310504 creator A5016491875 @default.
• W1877310504 creator A5021945153 @default.
• W1877310504 creator A5042107498 @default.
• W1877310504 creator A5042851664 @default.
• W1877310504 creator A5057739373 @default.
• W1877310504 creator A5061148557 @default.
• W1877310504 creator A5065577595 @default.
• W1877310504 creator A5084756058 @default.
• W1877310504 creator A5087577272 @default.
• W1877310504 creator A5087708317 @default.
• W1877310504 date "2015-10-29" @default.
• W1877310504 modified "2023-10-02" @default.
• W1877310504 title "No evidence for a J-shaped curve in treated hypertensive patients with increased cardiovascular risk: The VALUE trial" @default.
• W1877310504 cites W1819620602 @default.
• W1877310504 cites W1978821267 @default.
• W1877310504 cites W1989394631 @default.
• W1877310504 cites W2041159261 @default.
• W1877310504 cites W2079663279 @default.
• W1877310504 cites W2085989892 @default.
• W1877310504 cites W2092075924 @default.
• W1877310504 cites W2096901562 @default.
• W1877310504 cites W2116363103 @default.
• W1877310504 cites W2126125759 @default.
• W1877310504 cites W2127422554 @default.
• W1877310504 cites W2136145230 @default.
• W1877310504 cites W2137408480 @default.
• W1877310504 cites W2139400805 @default.
• W1877310504 cites W2164485047 @default.
• W1877310504 cites W2172032309 @default.
• W1877310504 cites W2502644872 @default.
• W1877310504 doi "https://doi.org/10.3109/08037051.2015.1106750" @default.
• W1877310504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26511535" @default.
• W1877310504 hasPublicationYear "2015" @default.
• W1877310504 type Work @default.
• W1877310504 sameAs 1877310504 @default.
• W1877310504 citedByCount "55" @default.
• W1877310504 countsByYear W18773105042013 @default.
• W1877310504 countsByYear W18773105042015 @default.
• W1877310504 countsByYear W18773105042016 @default.
• W1877310504 countsByYear W18773105042017 @default.
• W1877310504 countsByYear W18773105042018 @default.
• W1877310504 countsByYear W18773105042019 @default.
• W1877310504 countsByYear W18773105042020 @default.
• W1877310504 countsByYear W18773105042021 @default.
• W1877310504 countsByYear W18773105042022 @default.
• W1877310504 countsByYear W18773105042023 @default.
• W1877310504 crossrefType "journal-article" @default.
• W1877310504 hasAuthorship W1877310504A5000524196 @default.
• W1877310504 hasAuthorship W1877310504A5016491875 @default.
• W1877310504 hasAuthorship W1877310504A5021945153 @default.
• W1877310504 hasAuthorship W1877310504A5042107498 @default.
• W1877310504 hasAuthorship W1877310504A5042851664 @default.
• W1877310504 hasAuthorship W1877310504A5057739373 @default.
• W1877310504 hasAuthorship W1877310504A5061148557 @default.
• W1877310504 hasAuthorship W1877310504A5065577595 @default.
• W1877310504 hasAuthorship W1877310504A5084756058 @default.
• W1877310504 hasAuthorship W1877310504A5087577272 @default.
• W1877310504 hasAuthorship W1877310504A5087708317 @default.
• W1877310504 hasConcept C126322002 @default.
• W1877310504 hasConcept C127413603 @default.
• W1877310504 hasConcept C134018914 @default.
• W1877310504 hasConcept C164705383 @default.
• W1877310504 hasConcept C168563851 @default.
• W1877310504 hasConcept C17140001 @default.
• W1877310504 hasConcept C203092338 @default.
• W1877310504 hasConcept C2776002628 @default.
• W1877310504 hasConcept C2777387769 @default.
• W1877310504 hasConcept C2778198053 @default.
• W1877310504 hasConcept C2778213512 @default.
• W1877310504 hasConcept C2779646130 @default.
• W1877310504 hasConcept C2780221984 @default.
• W1877310504 hasConcept C2780645631 @default.
• W1877310504 hasConcept C2908647359 @default.
• W1877310504 hasConcept C500558357 @default.
• W1877310504 hasConcept C50382708 @default.
• W1877310504 hasConcept C555293320 @default.
• W1877310504 hasConcept C71924100 @default.
• W1877310504 hasConcept C78519656 @default.
• W1877310504 hasConcept C84393581 @default.
• W1877310504 hasConcept C99454951 @default.
• W1877310504 hasConceptScore W1877310504C126322002 @default.
• W1877310504 hasConceptScore W1877310504C127413603 @default.
• W1877310504 hasConceptScore W1877310504C134018914 @default.
• W1877310504 hasConceptScore W1877310504C164705383 @default.
• W1877310504 hasConceptScore W1877310504C168563851 @default.
• W1877310504 hasConceptScore W1877310504C17140001 @default.
• W1877310504 hasConceptScore W1877310504C203092338 @default.
• W1877310504 hasConceptScore W1877310504C2776002628 @default.
• W1877310504 hasConceptScore W1877310504C2777387769 @default.
• W1877310504 hasConceptScore W1877310504C2778198053 @default.
• W1877310504 hasConceptScore W1877310504C2778213512 @default.
• W1877310504 hasConceptScore W1877310504C2779646130 @default.
• W1877310504 hasConceptScore W1877310504C2780221984 @default.
• W1877310504 hasConceptScore W1877310504C2780645631 @default.
• W1877310504 hasConceptScore W1877310504C2908647359 @default.

• next