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- W1877311156 abstract "The compliance of a three-day course of artesunate (ARS)-mefloquine (MQ) (4 mg/kg body weight ARS once daily for three consecutive days, plus 15 and 10 mg/kg body weight MQ on the first and second days) was evaluated in a total of 240 patients (196 males and 44 females) who were attending the malaria clinics in Mae-Sot, Tak Province and presenting with symptomatic acute uncomplicated Plasmodium falciparum malaria. The gametocytocydal anti-malarial drug primaquine (PQ) is administered at the dose of 30 mg (0.6 mg/kg) on the last day. The first dose of the treatment was given to the patients under direct supervision. All patients were given the medication for self-treatment at home and were requested to come back for follow-up on day 3 of the initial treatment. The Kaplan- Meier estimate of the 42-day efficacy rate of this combination regimen was 99.2% (238/240). A three-day combination regimen of ARS-MQ provides excellent patient compliance with good efficacy and tolerability in the treatment of highly multidrug resistance falciparum malaria Based on whole blood MQ and plasma PQ concentrations on day 3 of the initial treatment, compliance with MQ and PQ in this three-day ARS-MQ combination regimen were 96.3% (207/215), and 98.5% (197/200), respectively." @default.
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- W1877311156 date "2010-01-01" @default.
- W1877311156 modified "2023-09-24" @default.
- W1877311156 title "Compliance with a three-day course of artesunate-mefloquine combination in an area of Thailand with highly multidrug resistant falciparum malaria" @default.
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