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• W1877391288 abstract "Summary Background There are few studies focusing on the comparison of resistance (Rrs) and reactance (Xrs) in impulse oscillometry system (IOS) in the bronchial challenge test using dose–response slope (DRS), a quantitative index of bronchial hyperresponsiveness. Material and Methods We conducted a case–control study of 144 asthmatic and 218 non‐asthmatic children to compare the diagnostic accuracy of two‐point linear DRS for FEV 1 , Rrs 5 , and Xrs 5 (DRS_FEV 1 , DRS_Rrs 5 , and DRS_Xrs 5 ) and assessed various diagnostic cut‐off points of provocation concentrations (PC) using receiver operating characteristic (ROC) curves. Results DRS_FEV 1 had a stronger correlation with DRS_Xrs 5 (r = 0.739, P < 0.001) than with DRS_Rrs 5 (r = 0.652, P < 0.001) and the area under the ROC curves of DRS_Xrs 5 (0.737) was similar to that of DRS_FEV 1 (0.732) and higher than that of DRS_Rrs 5 (0.668). The area under the ROC curves in order of greater value was as follows: absolute change of Xrs 5 (Abs_Xrs 5 ) (0.759) > percent change of FEV 1 (Pch_FEV 1 ) (0.735) > Pch_Xrs 5 (0.727) > Abs_Rrs 5 (0.690) > Pch_Rrs 5 (0.630). PC 78 _Xrs 5 and PC 0.17 _Xrs 5 of IOS showed considerably good sensitivity and specificity comparable to those of PC 20 _FEV 1 by spirometry. Additional 18 (13%) children who showed normal spirometric measures were identified as asthmatics with the use of IOS. Conclusion The utility of the DRS_Xrs 5 to differentiate asthmatics from controls was comparable to that of the DRS_FEV 1 and better than that of the DRS_Rrs 5 . In addition, IOS could detect additional asthmatic patients who did not show positive responses in spirometry. Pediatr Pulmonol. 2014; 49:521–528. © 2013 Wiley Periodicals, Inc." @default.
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• W1877391288 date "2013-09-04" @default.
• W1877391288 modified "2023-10-06" @default.
• W1877391288 title "Useful marker of oscillatory lung function in methacholine challenge test-comparison of reactance and resistance with dose-response slope" @default.
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• W1877391288 doi "https://doi.org/10.1002/ppul.22866" @default.
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