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- W1877394038 abstract "INTRODUCTION: Changes in pulmonary vessels in COPD are complex due to vascular remodeling and emphysema. Quantitative assessment of pulmonary vascular morphology on CT scan provides a unique measure of disease severity. We aimed to evaluate the relationships between CT density of pulmonary vessels and morphological assessments in COPD. METHODS:39 patients undergoing lung resection for localized neoplasm were studied (7 nonsmokers, 8 smokers with normal lung function and 24 COPD patients). Density of vessels RESULTS: There was a trend in COPD to lower CSA-CT, compared with nonsmokers (p=0.07). The PA/A ratio did not differ between groups. At the histological analysis, COPD patients had similar vessel density (CSA-Hist), less bronchioles (p=0,02) and less alveolar septa (p=0.001). In the whole population, CT assessed vessel density (CSA-CT) correlated with septal density (r=0.37,p CONCLUSION: In COPD, assessment of pulmonary vascular density by CT correlates with the microscopic integrity of lung parenchyma and small arteries." @default.
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- W1877394038 date "2014-09-01" @default.
- W1877394038 modified "2023-10-18" @default.
- W1877394038 title "Histological correlates of vascular density analysis by computer tomography in chronic obstructive pulmonary disease (COPD)" @default.
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