Matches in SemOpenAlex for { <https://semopenalex.org/work/W1877395005> ?p ?o ?g. }
- W1877395005 endingPage "2524" @default.
- W1877395005 startingPage "2507" @default.
- W1877395005 abstract "Anti-proliferative and pro-apoptotic effects of Bay leaf (Laurus nobilis) in mammalian cancer and HT-29 adenocarcinoma cells have been previously attributed to effects of polyphenolic and essential oil chemical species. Recently, we demonstrated differentiated growth-regulating effects of high (HFBL) versus low molecular mass (LFBL) aqueous fractions of bay leaf and now confirm by comparative effects on gene expression, that HFBL and LFBL suppress HT-29 growth by distinct mechanisms. Induction of intra-cellular lesions including DNA strand breakage by extra-cellular HFBL, invoked the hypothesis that iron-mediated reactive oxygen species with capacity to penetrate cell membrane, were responsible for HFBL-mediated effects, supported by equivalent effects of HFBL in combination with γ radiation. Activities of HFBL and LFBL were interpreted to reflect differentiated responses to iron-mediated reactive oxygen species (ROS), occurring either outside or inside cells. In the presence of LFBL, apoptotic death was relatively delayed compared with HFBL. ROS production by LFBL mediated p53-dependent apoptosis and recovery was suppressed by promoting G1/S phase arrest and failure of cellular tight junctions. In comparison, intra-cellular anti-oxidant protection exerted by LFBL was absent for extra-cellular HFBL (likely polysaccharide-rich), which potentiated more rapid apoptosis by producing DNA double strand breaks. Differentiated effects on expression of genes regulating ROS defense and chromatic condensation by LFBL versus HFBL, were observed. The results support ferrous iron in cell culture systems and potentially in vivo, can invoke different extra-cellular versus intra-cellular ROS-mediated chemistries, that may be regulated by exogenous, including dietary species." @default.
- W1877395005 created "2016-06-24" @default.
- W1877395005 creator A5004032927 @default.
- W1877395005 creator A5006556380 @default.
- W1877395005 creator A5007472322 @default.
- W1877395005 creator A5011230881 @default.
- W1877395005 creator A5017271798 @default.
- W1877395005 creator A5019021868 @default.
- W1877395005 creator A5025532964 @default.
- W1877395005 creator A5037629924 @default.
- W1877395005 creator A5050962911 @default.
- W1877395005 creator A5056339819 @default.
- W1877395005 creator A5065346454 @default.
- W1877395005 creator A5078535728 @default.
- W1877395005 creator A5086164069 @default.
- W1877395005 date "2015-01-01" @default.
- W1877395005 modified "2023-10-16" @default.
- W1877395005 title "RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells" @default.
- W1877395005 cites W1506555948 @default.
- W1877395005 cites W1964595762 @default.
- W1877395005 cites W1970517061 @default.
- W1877395005 cites W1975750363 @default.
- W1877395005 cites W1979905548 @default.
- W1877395005 cites W1981182593 @default.
- W1877395005 cites W1981752846 @default.
- W1877395005 cites W1982579497 @default.
- W1877395005 cites W1987898954 @default.
- W1877395005 cites W1988134858 @default.
- W1877395005 cites W1988428135 @default.
- W1877395005 cites W1989694400 @default.
- W1877395005 cites W1990736410 @default.
- W1877395005 cites W1991494214 @default.
- W1877395005 cites W1992987945 @default.
- W1877395005 cites W1995726115 @default.
- W1877395005 cites W1999395072 @default.
- W1877395005 cites W1999711892 @default.
- W1877395005 cites W2002096983 @default.
- W1877395005 cites W2004871972 @default.
- W1877395005 cites W2008593613 @default.
- W1877395005 cites W2012053348 @default.
- W1877395005 cites W2013708043 @default.
- W1877395005 cites W2016140258 @default.
- W1877395005 cites W2019453869 @default.
- W1877395005 cites W2021828559 @default.
- W1877395005 cites W2023755204 @default.
- W1877395005 cites W2024810376 @default.
- W1877395005 cites W2027000922 @default.
- W1877395005 cites W2028224002 @default.
- W1877395005 cites W2029022814 @default.
- W1877395005 cites W2029459160 @default.
- W1877395005 cites W2030070767 @default.
- W1877395005 cites W2030207460 @default.
- W1877395005 cites W2030283142 @default.
- W1877395005 cites W2030888640 @default.
- W1877395005 cites W2032330270 @default.
- W1877395005 cites W2034004577 @default.
- W1877395005 cites W2034409892 @default.
- W1877395005 cites W2038173255 @default.
- W1877395005 cites W2039986962 @default.
- W1877395005 cites W2042119456 @default.
- W1877395005 cites W2044387885 @default.
- W1877395005 cites W2044831115 @default.
- W1877395005 cites W2049159971 @default.
- W1877395005 cites W2051670105 @default.
- W1877395005 cites W2053822327 @default.
- W1877395005 cites W2057896776 @default.
- W1877395005 cites W2060066334 @default.
- W1877395005 cites W2061385217 @default.
- W1877395005 cites W2064052294 @default.
- W1877395005 cites W2064519035 @default.
- W1877395005 cites W2065942363 @default.
- W1877395005 cites W2067708575 @default.
- W1877395005 cites W2072489106 @default.
- W1877395005 cites W2073946308 @default.
- W1877395005 cites W2074938084 @default.
- W1877395005 cites W2076265695 @default.
- W1877395005 cites W2076273397 @default.
- W1877395005 cites W2077283147 @default.
- W1877395005 cites W2078969352 @default.
- W1877395005 cites W2081971791 @default.
- W1877395005 cites W2086939267 @default.
- W1877395005 cites W2087739608 @default.
- W1877395005 cites W2105237310 @default.
- W1877395005 cites W2108360007 @default.
- W1877395005 cites W2111125738 @default.
- W1877395005 cites W2112479759 @default.
- W1877395005 cites W2113921159 @default.
- W1877395005 cites W2116277556 @default.
- W1877395005 cites W2132542247 @default.
- W1877395005 cites W2134087142 @default.
- W1877395005 cites W2136036894 @default.
- W1877395005 cites W2144803920 @default.
- W1877395005 cites W2145339991 @default.
- W1877395005 cites W2145690501 @default.
- W1877395005 cites W2150122219 @default.
- W1877395005 cites W2150642119 @default.
- W1877395005 cites W2150710841 @default.
- W1877395005 cites W2156114860 @default.