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- W187749420 abstract "Under experimental conditions, the corticotropin releasing factor-binding protein (CRF-BP) is able to bind CRF and render it biologically inactive. Because CRF-BP expression overlaps with CRF receptor expression in several areas of the brain, including the pituitary gland, it has been postulated that its function is to modulate the neuroendocrine and transmitter activities of CRF. The presence of CRF-BP in the periphery of higher primates as well indicates that this protein is involved in modulating the action of CRF in the periphery, where CRF has known proinflammatory effects (this is in contrast to the centrally derived anti-inflammatory action of CRF via the release of cortisol). Thus, the CRF-BP may play a pivotal role in the crossover of endocrine, immune, and higher functions in both acute and chronic stress responses." @default.
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- W187749420 date "2007-01-01" @default.
- W187749420 modified "2023-09-27" @default.
- W187749420 title "Corticotropin Releasing Factor-Binding Protein" @default.
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- W187749420 doi "https://doi.org/10.1016/b978-012373947-6.00101-x" @default.
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