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- W187764372 abstract "The chapter presents caloric-restriction-(CR)-associated alterations in rodents and primates from laboratory findings .CR effects could differ in several aspects of physiology from those of fasting (starvation), but the hormonal profile of CR (lower plasma leptin, insulin, growth hormone and gonadotropins, and higher plasma free corticosterone) is similar to that of fasting. The effects of CR on longevity in humans have not been evaluated directly. Laboratory findings of CR in rodents such as small body, modulation of hyperglycemia and insulinemia, low body temperature, transient reduction of metabolic rate, altered energy metabolism, alteration of lipid metabolism, lower fat mass, phenotypic alteration of white adipose tissue, protection against internal oxidative and environmental stresses, slow skeletal maturation, more fertility later in life, and slow sexual maturation are presented in this chapter. Interpretation of the beneficial actions of CR based on the adaptive response hypothesis is also presented in this chapter. The genes or signal cascades altered by CR could be the principle target for generating novel mutant-animal models that show suppressed aging processes and live longer. Moreover, CR mimetics, which are applicable in humans, may represent one strategy to modulate aging processes and longevity. Therefore, the chapter emphasizes the importance of dietary and calorie interventions and the interpretation of their effects in aging research, particularly in rodents, to humans. Laboratory findings in CR nonhuman primates are also discussed in this chapter." @default.
- W187764372 created "2016-06-24" @default.
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- W187764372 date "2005-01-01" @default.
- W187764372 modified "2023-09-27" @default.
- W187764372 title "Laboratory Findings of Caloric Restriction in Rodents and Primates" @default.
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- W187764372 doi "https://doi.org/10.1016/s0065-2423(04)39008-6" @default.
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