Matches in SemOpenAlex for { <https://semopenalex.org/work/W1877760087> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1877760087 abstract "Metabolomics investigations hold promise for the characterization of small molecules, metabolites, which govern the ultimate manifestation of cardiac phenotypes. In this study, we employed a mass spectrometry-based metabolomics approach to identify metabolic marker(s), which dynamically reflect the cardiac performance of heart failure patients amid the implantation of mechanical circulatory support. Using the MRM-based and triple quadrupole technology platform, we have quantified 266 metabolites native to human plasma and collected from thirteen heart failure patients. The temporal profile of these metabolites was sampled from 1 day prior to the implantation of mechanical circulatory support, as well as 1-, 3-, 5-, and 7-day following their surgical interventions. We identified subgroups of these metabolites with coordinated behaviors that are interesting to their diseased phenotypes. In a pair-wise correlation analysis, 36.8% (98 out of 266) of metabolites were significantly correlated. Intriguingly, majority of which (65 out of 98) are representing the functional groups of phosphatidylcholines; several of them are known to have close associations with the pathogenesis of cardiovascular diseases. In addition, there are 33 metabolites contributing to multiple functional groups, including twelve of them belong to sphingomyelines, ten of them in the family of lysophosphatidylcholines, eight amino acids (Gln, Ser, Ala, His, Lys, Gly, Thr, and Arg), as well as three fatty acids (eicosapentaenoic acid, pentadecenoic acid, and heptadecenoic acid). The behaviors of these 266 metabolites have constituted individualized metabolic fingerprints. Delineation of the intrinsic relationships among alterations in distinct metabolite groups and their reflected cardiac function will enable us to identify new metabolic markers aiding stratification and/or prediction on the clinical outcome of each individual patient undergoing the treatment of mechanical circulatory support. This personalized metabolic fingerprint will offer unique prognostic utilities, supporting clinical decision-making process to deliver intervention that is most effective and beneficial to an individual." @default.
- W1877760087 created "2016-06-24" @default.
- W1877760087 creator A5002395110 @default.
- W1877760087 creator A5006098122 @default.
- W1877760087 creator A5006187314 @default.
- W1877760087 creator A5039675166 @default.
- W1877760087 creator A5056076078 @default.
- W1877760087 creator A5059163885 @default.
- W1877760087 creator A5063504685 @default.
- W1877760087 creator A5071672663 @default.
- W1877760087 creator A5073504925 @default.
- W1877760087 creator A5073665638 @default.
- W1877760087 date "2014-07-18" @default.
- W1877760087 modified "2023-09-30" @default.
- W1877760087 title "Abstract 112: Targeted Metabolomics Profiling of Heart Failure Patients Undergoing Mechanical Circulatory Support" @default.
- W1877760087 doi "https://doi.org/10.1161/res.115.suppl_1.112" @default.
- W1877760087 hasPublicationYear "2014" @default.
- W1877760087 type Work @default.
- W1877760087 sameAs 1877760087 @default.
- W1877760087 citedByCount "0" @default.
- W1877760087 crossrefType "journal-article" @default.
- W1877760087 hasAuthorship W1877760087A5002395110 @default.
- W1877760087 hasAuthorship W1877760087A5006098122 @default.
- W1877760087 hasAuthorship W1877760087A5006187314 @default.
- W1877760087 hasAuthorship W1877760087A5039675166 @default.
- W1877760087 hasAuthorship W1877760087A5056076078 @default.
- W1877760087 hasAuthorship W1877760087A5059163885 @default.
- W1877760087 hasAuthorship W1877760087A5063504685 @default.
- W1877760087 hasAuthorship W1877760087A5071672663 @default.
- W1877760087 hasAuthorship W1877760087A5073504925 @default.
- W1877760087 hasAuthorship W1877760087A5073665638 @default.
- W1877760087 hasConcept C104317684 @default.
- W1877760087 hasConcept C126322002 @default.
- W1877760087 hasConcept C127716648 @default.
- W1877760087 hasConcept C135870905 @default.
- W1877760087 hasConcept C19038510 @default.
- W1877760087 hasConcept C192989942 @default.
- W1877760087 hasConcept C21565614 @default.
- W1877760087 hasConcept C2776091944 @default.
- W1877760087 hasConcept C2777477808 @default.
- W1877760087 hasConcept C2778198053 @default.
- W1877760087 hasConcept C2780942790 @default.
- W1877760087 hasConcept C515207424 @default.
- W1877760087 hasConcept C543025807 @default.
- W1877760087 hasConcept C55493867 @default.
- W1877760087 hasConcept C60644358 @default.
- W1877760087 hasConcept C62231903 @default.
- W1877760087 hasConcept C71924100 @default.
- W1877760087 hasConcept C72859922 @default.
- W1877760087 hasConcept C86803240 @default.
- W1877760087 hasConceptScore W1877760087C104317684 @default.
- W1877760087 hasConceptScore W1877760087C126322002 @default.
- W1877760087 hasConceptScore W1877760087C127716648 @default.
- W1877760087 hasConceptScore W1877760087C135870905 @default.
- W1877760087 hasConceptScore W1877760087C19038510 @default.
- W1877760087 hasConceptScore W1877760087C192989942 @default.
- W1877760087 hasConceptScore W1877760087C21565614 @default.
- W1877760087 hasConceptScore W1877760087C2776091944 @default.
- W1877760087 hasConceptScore W1877760087C2777477808 @default.
- W1877760087 hasConceptScore W1877760087C2778198053 @default.
- W1877760087 hasConceptScore W1877760087C2780942790 @default.
- W1877760087 hasConceptScore W1877760087C515207424 @default.
- W1877760087 hasConceptScore W1877760087C543025807 @default.
- W1877760087 hasConceptScore W1877760087C55493867 @default.
- W1877760087 hasConceptScore W1877760087C60644358 @default.
- W1877760087 hasConceptScore W1877760087C62231903 @default.
- W1877760087 hasConceptScore W1877760087C71924100 @default.
- W1877760087 hasConceptScore W1877760087C72859922 @default.
- W1877760087 hasConceptScore W1877760087C86803240 @default.
- W1877760087 hasIssue "suppl_1" @default.
- W1877760087 hasLocation W18777600871 @default.
- W1877760087 hasOpenAccess W1877760087 @default.
- W1877760087 hasPrimaryLocation W18777600871 @default.
- W1877760087 hasRelatedWork W1977479799 @default.
- W1877760087 hasRelatedWork W1978028581 @default.
- W1877760087 hasRelatedWork W2036720248 @default.
- W1877760087 hasRelatedWork W2091119693 @default.
- W1877760087 hasRelatedWork W2127708170 @default.
- W1877760087 hasRelatedWork W2217765691 @default.
- W1877760087 hasRelatedWork W2313430442 @default.
- W1877760087 hasRelatedWork W2394926233 @default.
- W1877760087 hasRelatedWork W2505549171 @default.
- W1877760087 hasRelatedWork W2516755168 @default.
- W1877760087 hasRelatedWork W2623972421 @default.
- W1877760087 hasRelatedWork W2769797463 @default.
- W1877760087 hasRelatedWork W2920798634 @default.
- W1877760087 hasRelatedWork W2924491943 @default.
- W1877760087 hasRelatedWork W3021985788 @default.
- W1877760087 hasRelatedWork W3118536569 @default.
- W1877760087 hasRelatedWork W3119681239 @default.
- W1877760087 hasRelatedWork W3121354799 @default.
- W1877760087 hasRelatedWork W3125488374 @default.
- W1877760087 hasRelatedWork W3192271959 @default.
- W1877760087 hasVolume "115" @default.
- W1877760087 isParatext "false" @default.
- W1877760087 isRetracted "false" @default.
- W1877760087 magId "1877760087" @default.
- W1877760087 workType "article" @default.