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- W1877831570 abstract "10 mg/kg/day for three days) were the only regimens that had lower clinical failure rates than penicillin when analyzed independently, with ORs of 0.49 (95% CI 0.03 to 0.81) and 0.08 (95% CI 0.01 to 0.64), respectively. For the 13 trials that looked at later clinical recurrence, results were equivocal for penicillin versus short-course antibiotics. For bacteriological cure, early failure to eradicate group A streptococcus (GAS) (at the end of the course of antibiotics) was equivalent in the two groups but, again, shortcourse cefuroxime or the higher dose azithromycin were superior to penicillin when analyzed independently (ORs of 0.64 [95% CI 0.48 to 0.87] and 0.29 [95% CI 0.14 to 0.61], respectively). Late bacteriological recurrences were more common in the short-course group but occurred primarily with azithromycin 10 mg/kg for three days. Adverse events were mainly gastrointestinal and were almost twice as common in the short-course group (OR 1.85, 95% CI 1.55 to 2.21). Such events were particularly common with azithromycin 20 mg/kg/day (OR 5.13, 95% CI 2.76 to 9.54) and occurred in approximately 5% of the penicillin group versus 10% of the short-course group. Noncompliance was 24% in the penicillin group versus 6% in the short-course group in the six trials reporting this outcome." @default.
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- W1877831570 date "2010-12-01" @default.
- W1877831570 modified "2023-09-26" @default.
- W1877831570 title "Streptococcal pharyngitis – time to move beyond penicillins?" @default.
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- W1877831570 doi "https://doi.org/10.1093/pch/15.10.643" @default.
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