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- W187785512 abstract "Caloric restriction (CR) mitigates aging; however, mechanisms are poorly understood. The 'uncoupling to survive' theory suggests that mitochondrial uncoupling protects cells from reactive oxygen species (ROS). It is unclear how uncoupling protein 3 (UCP3) in skeletal muscle is involved. Objective To characterize the effects of 2 wk 40% CR in wildtype (Wt) and UCP3 transgenic (UCP3 Tg) mice. Hypothesis In an already uncoupled system, CR provides no further ROS protection. Approaches Muscle mitochondria and whole body assessments of UCP3's contribution to uncoupling and oxidative stress. Results In ad libitum fed mice, UCP3 Tg weighed less (p < 0.005; n = 18), had less muscle (p < 0.005; n = 8-9), expended ~5% more energy and burned more carbohydrate (n = 9) than Wt. UCP3 Tg mitochondria produced less ROS than Wt (p < 0.05; n = 4-5). CR in Wt mice did not decrease ROS production and increased it in UCP3 Tg (p < 0.05). CR tended to increase UCP3 and ANT in Wt and decrease ANT in UCP3 Tg (n = 3). MnSOD was unchanged in both genotypes, although UCP3 Tg had less MnSOD vs. Wt (p < 0.005; n = 3). Oxidative damage (4-hydroxynonenal adducts) was unchanged in both genotypes (n = 3). However, 1 mo CR decreased ROS production in Wt, but not in UCP3 Tg mice (n = 2-4). In summary, 2 wk CR is insufficient in mice, unlike rats (Bevilacqua et al, 2004), to mitigate oxidative stress; 1 mo is effective. Surprisingly, ROS production increases in UCP3 Tg mitochondria with 2 wk CR. Support: NSERC of Canada." @default.
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- W187785512 date "2009-04-01" @default.
- W187785512 modified "2023-10-18" @default.
- W187785512 title "Mitochondrial uncoupling and remodeling during caloric restriction: Implications for oxidative stress and aging" @default.
- W187785512 doi "https://doi.org/10.1096/fasebj.23.1_supplement.954.14" @default.
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