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• W1877992021 endingPage "3138" @default.
• W1877992021 startingPage "3130" @default.
• W1877992021 abstract "The 3' untranslated region (3'-UTR) has been implicated in the estrogen stabilization of hepatic Xenopus laevis vitellogenin mRNA. We used RNA gel mobility shift assays to demonstrate that Xenopus liver contains a factor which binds with very high specificity to a segment of the 3'-UTR of vitellogenin B1 and B2 mRNAs. We detected a single high-affinity binding site in the vitellogenin mRNA 3'-UTR and localized the binding site to a 27-nucleotide region. Since binding was abolished by proteinase K digestion, at least a component of the factor is a protein. Following estrogen administration, binding was induced approximately four- to fivefold in extracts from liver polysomes. The hepatic vitellogenin mRNA-binding protein was found in both polysomes and cytosol. Since the protein was also estrogen inducible in cytosol, this represents a genuine induction, not simply recruitment of the cytosolic protein into polysomes. UV cross-linking studies with the 27-nucleotide recognition sequence revealed bands corresponding to bound proteins with apparent molecular weights of 71,000 and 141,000. This appears to be the first example of steroid hormone-inducible proteins binding to an mRNA 3'-UTR. Its induction by estrogen and its sequence-specific binding to a region of vitellogenin mRNA important in estrogen-mediated stabilization suggest that the protein may play a role in the regulation of mRNA stability." @default.
• W1877992021 created "2016-06-24" @default.
• W1877992021 creator A5057385624 @default.
• W1877992021 creator A5061599949 @default.
• W1877992021 date "1994-05-01" @default.
• W1877992021 modified "2023-09-26" @default.
• W1877992021 title "An estrogen-inducible protein binds specifically to a sequence in the 3' untranslated region of estrogen-stabilized vitellogenin mRNA" @default.
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• W1877992021 doi "https://doi.org/10.1128/mcb.14.5.3130-3138.1994" @default.
• W1877992021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/358680" @default.
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• W1877992021 hasPublicationYear "1994" @default.
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