FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878008672> ?p ?o ?g. }

• W1878008672 endingPage "124" @default.
• W1878008672 startingPage "115" @default.
• W1878008672 abstract "Thyrotropin-releasing hormone (TRH) synthesized in hypothalamic paraventricular nucleus directs hypothalamus-pituitary-thyroid (HPT) axis function, regulating thyrotropin release from adenohypophysis and thyroid hormones serum concentration. Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis. It is unknown whether dietary Zn deficiency down-regulates PPII. Our aim was to compare adenohypohyseal and medial-basal-hypothalamic PPII activity and expression of adult rats fed a Zn-deficient diet (2ppm) throughout their lifespan (DD), prenatally (DC) or after weaning (CD) vs. that of animals fed a control diet (20ppm:CC). Female rats consumed a Zn-deficient or control diet from two weeks before gestation and up to the end of lactation. We analyzed adenohypophyseal and medial-basal-hypothalamic PPII activity of dams and male offspring when adults; its relation to median eminence TRH, serum thyrotropin, leptin and thyroid hormones concentration. Offspring ate the same diet as their dams (CC, DD) or were switched from dietary regime after weaning (CD, DC) and until 2.5 months of age. DD males showed decreased adenohypophyseal and medial-basal-hypothalamic PPII activity, along with high thyrotropin serum concentration. Post-weaning Zn-deficiency (CD) decreased PPII activity only in adenohypophysis and increased thyrotropin circulating levels. Zn-replenishment (DC) normalized PPII activity in both regions and serum thyrotropin concentration. Adenohypophyseal PPII activity decreased and prolactin levels increased in Zn-deficient dams. We concluded that long-term changes in dietary Zn down-regulate PPII activity independently of T3, increasing thyrotropin serum concentration, overall resembling sub-clinical hypothyroidism." @default.
• W1878008672 created "2016-06-24" @default.
• W1878008672 creator A5006127779 @default.
• W1878008672 creator A5031949904 @default.
• W1878008672 creator A5055154817 @default.
• W1878008672 creator A5056583681 @default.
• W1878008672 creator A5074073316 @default.
• W1878008672 creator A5090513269 @default.
• W1878008672 date "2015-08-24" @default.
• W1878008672 modified "2023-10-15" @default.
• W1878008672 title "Mediobasal hypothalamic and adenohypophyseal TRH‐degrading enzyme (PPII) is down‐regulated by zinc deficiency" @default.
• W1878008672 cites W1506252932 @default.
• W1878008672 cites W1531562529 @default.
• W1878008672 cites W1775749144 @default.
• W1878008672 cites W1780331520 @default.
• W1878008672 cites W1836897676 @default.
• W1878008672 cites W1900905870 @default.
• W1878008672 cites W1923690158 @default.
• W1878008672 cites W1930588251 @default.
• W1878008672 cites W1945671298 @default.
• W1878008672 cites W1959663942 @default.
• W1878008672 cites W1968329147 @default.
• W1878008672 cites W1970384874 @default.
• W1878008672 cites W1970586448 @default.
• W1878008672 cites W1972620224 @default.
• W1878008672 cites W1975727082 @default.
• W1878008672 cites W1975976379 @default.
• W1878008672 cites W1976224963 @default.
• W1878008672 cites W1980362986 @default.
• W1878008672 cites W1987461858 @default.
• W1878008672 cites W1988690043 @default.
• W1878008672 cites W1992034175 @default.
• W1878008672 cites W1992855112 @default.
• W1878008672 cites W1994127414 @default.
• W1878008672 cites W1994730240 @default.
• W1878008672 cites W1995833977 @default.
• W1878008672 cites W2007106946 @default.
• W1878008672 cites W2008194780 @default.
• W1878008672 cites W2010849256 @default.
• W1878008672 cites W2012499019 @default.
• W1878008672 cites W2016339654 @default.
• W1878008672 cites W2017890692 @default.
• W1878008672 cites W2020375505 @default.
• W1878008672 cites W2020378174 @default.
• W1878008672 cites W2021348472 @default.
• W1878008672 cites W2024794762 @default.
• W1878008672 cites W2025738278 @default.
• W1878008672 cites W2026465058 @default.
• W1878008672 cites W2026959006 @default.
• W1878008672 cites W2030432805 @default.
• W1878008672 cites W2030991261 @default.
• W1878008672 cites W2034669253 @default.
• W1878008672 cites W2049228701 @default.
• W1878008672 cites W2057286656 @default.
• W1878008672 cites W2058153407 @default.
• W1878008672 cites W2062732320 @default.
• W1878008672 cites W2069486676 @default.
• W1878008672 cites W2073890054 @default.
• W1878008672 cites W2073982436 @default.
• W1878008672 cites W2076945098 @default.
• W1878008672 cites W2078230942 @default.
• W1878008672 cites W2082422908 @default.
• W1878008672 cites W2083199795 @default.
• W1878008672 cites W2085205986 @default.
• W1878008672 cites W2087695877 @default.
• W1878008672 cites W2088589799 @default.
• W1878008672 cites W2092268368 @default.
• W1878008672 cites W2097292276 @default.
• W1878008672 cites W2102936024 @default.
• W1878008672 cites W2106547631 @default.
• W1878008672 cites W2110652761 @default.
• W1878008672 cites W2112470103 @default.
• W1878008672 cites W2116886339 @default.
• W1878008672 cites W2121662324 @default.
• W1878008672 cites W2125040071 @default.
• W1878008672 cites W2129285121 @default.
• W1878008672 cites W2129625801 @default.
• W1878008672 cites W2130606778 @default.
• W1878008672 cites W2138149556 @default.
• W1878008672 cites W2144305979 @default.
• W1878008672 cites W2151090955 @default.
• W1878008672 cites W2151456358 @default.
• W1878008672 cites W2159871369 @default.
• W1878008672 cites W2171835330 @default.
• W1878008672 cites W2225137686 @default.
• W1878008672 cites W2248493594 @default.
• W1878008672 cites W263414040 @default.
• W1878008672 cites W33195596 @default.
• W1878008672 doi "https://doi.org/10.1016/j.ijdevneu.2015.08.001" @default.
• W1878008672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26315400" @default.
• W1878008672 hasPublicationYear "2015" @default.
• W1878008672 type Work @default.
• W1878008672 sameAs 1878008672 @default.
• W1878008672 citedByCount "7" @default.
• W1878008672 countsByYear W18780086722016 @default.
• W1878008672 countsByYear W18780086722017 @default.
• W1878008672 countsByYear W18780086722019 @default.
• W1878008672 countsByYear W18780086722021 @default.

• next