FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878018588> ?p ?o ?g. }

• W1878018588 endingPage "440" @default.
• W1878018588 startingPage "429" @default.
• W1878018588 abstract "Two new mutations are described which, together, eliminate essentially all the aminotransferase activity required for de novo biosynthesis of tyrosine, phenylalanine, and aspartic acid in a K-12 strain of Escherichia coli. One mutation, designated tyrB, lies at about 80 min on the E. coli map and inactivates the tyrosine-repressible tyrosine/phenylalanine aminotransferase. The second mutation, aspC, maps at about 20 min and inactivates a nonrespressible aspartate aminotransferase that also has activity on the aromatic amino acids. In ilvE- strains, which lack the branched-chain amino acid aminotransferase, the presence of either the tyrosine-repressible aminotransferase or the aspartate aminotransferase is sufficient for growth in the absence of exogenous tyrosine, phenylalanine, or aspartate; the tyrosine-repressible enzyme is also active in leucine biosynthesis. The ilvE gene product alone can reverse a phenylalanine requirement. Biochemical studies on extracts of strains carrying combinations of these aminotransferase mutations confirm the existence of two distinct enzymes with overlapping specificities for the alpha-keto acid analogues of tyrosine, phenylalanine, and aspartate. These enzymes can be distinguished by electrophoretic mobilities, by kinetic parameters using various substrates, and by a difference in tyrosine repressibility. In extracts of an ilvE- tyrB- aspC- triple mutant, no aminotransferase activity for the alpha-keto acids of tyrosine, phenylalanine, or aspartate could be detected." @default.
• W1878018588 created "2016-06-24" @default.
• W1878018588 creator A5025753082 @default.
• W1878018588 creator A5047732176 @default.
• W1878018588 date "1977-04-01" @default.
• W1878018588 modified "2023-09-24" @default.
• W1878018588 title "Escherichia coli mutants deficient in the aspartate and aromatic amino acid aminotransferases" @default.
• W1878018588 cites W1020831558 @default.
• W1878018588 cites W1023150109 @default.
• W1878018588 cites W1139442884 @default.
• W1878018588 cites W1486946238 @default.
• W1878018588 cites W1491904160 @default.
• W1878018588 cites W1507458182 @default.
• W1878018588 cites W1531075241 @default.
• W1878018588 cites W1557897326 @default.
• W1878018588 cites W1567134389 @default.
• W1878018588 cites W1569465588 @default.
• W1878018588 cites W1592731945 @default.
• W1878018588 cites W1676196619 @default.
• W1878018588 cites W1775749144 @default.
• W1878018588 cites W1832865311 @default.
• W1878018588 cites W1847296879 @default.
• W1878018588 cites W1896289109 @default.
• W1878018588 cites W1965674955 @default.
• W1878018588 cites W1998247911 @default.
• W1878018588 cites W2020040854 @default.
• W1878018588 cites W2026343562 @default.
• W1878018588 cites W2034655946 @default.
• W1878018588 cites W2036031177 @default.
• W1878018588 cites W2042596983 @default.
• W1878018588 cites W2079969029 @default.
• W1878018588 cites W2084053700 @default.
• W1878018588 cites W2105752797 @default.
• W1878018588 cites W2129043215 @default.
• W1878018588 cites W2170211468 @default.
• W1878018588 cites W35925210 @default.
• W1878018588 cites W4236955515 @default.
• W1878018588 cites W4339437 @default.
• W1878018588 doi "https://doi.org/10.1128/jb.130.1.429-440.1977" @default.
• W1878018588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/235221" @default.
• W1878018588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15983" @default.
• W1878018588 hasPublicationYear "1977" @default.
• W1878018588 type Work @default.
• W1878018588 sameAs 1878018588 @default.
• W1878018588 citedByCount "165" @default.
• W1878018588 countsByYear W18780185882012 @default.
• W1878018588 countsByYear W18780185882013 @default.
• W1878018588 countsByYear W18780185882014 @default.
• W1878018588 countsByYear W18780185882015 @default.
• W1878018588 countsByYear W18780185882016 @default.
• W1878018588 countsByYear W18780185882017 @default.
• W1878018588 countsByYear W18780185882018 @default.
• W1878018588 countsByYear W18780185882019 @default.
• W1878018588 countsByYear W18780185882020 @default.
• W1878018588 countsByYear W18780185882021 @default.
• W1878018588 countsByYear W18780185882022 @default.
• W1878018588 countsByYear W18780185882023 @default.
• W1878018588 crossrefType "journal-article" @default.
• W1878018588 hasAuthorship W1878018588A5025753082 @default.
• W1878018588 hasAuthorship W1878018588A5047732176 @default.
• W1878018588 hasBestOaLocation W18780185881 @default.
• W1878018588 hasConcept C104317684 @default.
• W1878018588 hasConcept C132154277 @default.
• W1878018588 hasConcept C143065580 @default.
• W1878018588 hasConcept C153911025 @default.
• W1878018588 hasConcept C181199279 @default.
• W1878018588 hasConcept C188142797 @default.
• W1878018588 hasConcept C2776016237 @default.
• W1878018588 hasConcept C2776165026 @default.
• W1878018588 hasConcept C2776491826 @default.
• W1878018588 hasConcept C2776580952 @default.
• W1878018588 hasConcept C2777431362 @default.
• W1878018588 hasConcept C2777992278 @default.
• W1878018588 hasConcept C501734568 @default.
• W1878018588 hasConcept C515207424 @default.
• W1878018588 hasConcept C547475151 @default.
• W1878018588 hasConcept C553450214 @default.
• W1878018588 hasConcept C55493867 @default.
• W1878018588 hasConcept C86803240 @default.
• W1878018588 hasConceptScore W1878018588C104317684 @default.
• W1878018588 hasConceptScore W1878018588C132154277 @default.
• W1878018588 hasConceptScore W1878018588C143065580 @default.
• W1878018588 hasConceptScore W1878018588C153911025 @default.
• W1878018588 hasConceptScore W1878018588C181199279 @default.
• W1878018588 hasConceptScore W1878018588C188142797 @default.
• W1878018588 hasConceptScore W1878018588C2776016237 @default.
• W1878018588 hasConceptScore W1878018588C2776165026 @default.
• W1878018588 hasConceptScore W1878018588C2776491826 @default.
• W1878018588 hasConceptScore W1878018588C2776580952 @default.
• W1878018588 hasConceptScore W1878018588C2777431362 @default.
• W1878018588 hasConceptScore W1878018588C2777992278 @default.
• W1878018588 hasConceptScore W1878018588C501734568 @default.
• W1878018588 hasConceptScore W1878018588C515207424 @default.
• W1878018588 hasConceptScore W1878018588C547475151 @default.
• W1878018588 hasConceptScore W1878018588C553450214 @default.
• W1878018588 hasConceptScore W1878018588C55493867 @default.
• W1878018588 hasConceptScore W1878018588C86803240 @default.
• W1878018588 hasIssue "1" @default.

• next