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- W187804908 abstract "While the sarcolemmal calmodulin-dependent calcium pump (PMCA) is thought to play a minor role in beat-to-beat sarcolemmal Ca2+-movements in the myocardium compared to the Na+/Ca2+-exchanger, its role in long-term processes such as growth and differentiation has not been explored. In a first step to address this question we, therefore, asked whether mRNA expression of the four PMCA isoforms and/or splicing variants was altered during normal and hypertrophic growth of the myocardium and during differentiation of skeletal myoblasts. Differentiation of L6 rat myoblasts to myotubes was paralleled by novel expression of PMCA 3f (i.e., isoform 3, splice variant f). In myocardial cells, transition from the neonatal to the adult phenotype was accompanied by novel expression of PMCA 3e while all other isoforms and splice variants remained stable. This splicing of PMCA 3 was dramatically accelerated by hypertrophic stimuli. In the adult SHR model of hypertrophy no qualitative changes in PMCA expression pattern occurred. We conclude: (1) isoform 3 is the most plastic isoform in the myocardium; (2) PMCA 3e may either determine functions of the adult myocardium or be involved in the transition from the neonatal to the adult phenotype; (3) together with the experiments in myogenic model systems, these results suggest a role of the sarcolemmal calcium pump in long-term processes such as myocardial growth and hypertrophy." @default.
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- W187804908 date "1998-01-01" @default.
- W187804908 modified "2023-09-26" @default.
- W187804908 title "Regulation of mRNA-expression of the sarcolemmal calmodulin-dependent calcium pump in cardiac hypertrophy" @default.
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- W187804908 doi "https://doi.org/10.1007/978-3-642-48670-8_9" @default.
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