FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878282244> ?p ?o ?g. }

• W1878282244 endingPage "16210J" @default.
• W1878282244 startingPage "16210J" @default.
• W1878282244 abstract "The purpose of this study was to determine whether lidocaine is absorbed from the trachea during the artificial circulation of cardiopulmonary resuscitation. The tissue distribution of lidocaine was investigated in eight individuals (Cases 1-8) who underwent cardiopulmonary resuscitation before being pronounced dead. In Cases 1-4, there was no restoration of heart beat during cardiopulmonary resuscitation. Heart massage had been continued for 5 min in Cases 1 and 2, and for 60 min in Cases 3 and 4. Relatively high concentrations of lidocaine (more than 0.1 mg/L) were detected in the blood left in the heart and/or in the large thoracic vessels in the four cases. In Cases 1-3, a large proportion of the lidocaine detected in these blood samples may have diffused from the trachea after cessation of cardiopulmonary resuscitation since no lidocaine was detected in the cerebrospinal fluid, cerebrum, liver, right kidney, and/or right femoral muscle. In Case 4, however, tracheal lidocaine was thought to have been absorbed during cardiopulmonary resuscitation because 0.167-0.340 mg/L or mg/kg lidocaine was detected in the cerebrospinal fluid, liver, right kidney, and right femoral muscle. This was substantiated in experiments performed in rabbit carcasses given 50 microL/kg Xylocaine jelly (a 2% lidocaine hydrochloride preparation) intratracheally, followed by rhythmical thoracic compressions (100-150 times per minute) for 60 min. A possible reason for lack of absorption of lidocaine from the trachea of Case 3 during a 60-min cardiopulmonary resuscitation procedure may have been that effective blood circulation was not obtained during cardiopulmonary resuscitation because of bleeding and pulmonary collapse. Cases 5-8 survived for 3 h to 10 days after successful cardiopulmonary resuscitation; it was obvious that lidocaine was distributed to the tissues under the influence of the natural circulation. The kidney to liver lidocaine ratio in Case 4 (0.8) was much lower than that in Cases 5-8 (1.3-4.6), although the lidocaine ratio in the blood in the left ventricle when compared to blood in the right ventricle was similar in the five cases. The kidney to liver lidocaine ratio may be helpful in judging whether the lidocaine detected was absorbed during the artificial circulation of cardiopulmonary resuscitation or naturally. Additionally, postmortem diffusion of tracheal lidocaine into the blood in the left ventricle was much greater than into the blood in the right ventricle due to their anatomical location during a supine position. The pattern of tissue distribution of lidocaine gives useful information on the state of decedents during cardiopulmonary resuscitation." @default.
• W1878282244 created "2016-06-24" @default.
• W1878282244 creator A5041304842 @default.
• W1878282244 creator A5043499681 @default.
• W1878282244 date "1998-05-01" @default.
• W1878282244 modified "2023-09-27" @default.
• W1878282244 title "Absorption of Intubation-Related Lidocaine from the Trachea during Prolonged Cardiopulmonary Resuscitation" @default.
• W1878282244 cites W1579472385 @default.
• W1878282244 cites W1601963692 @default.
• W1878282244 cites W1764632566 @default.
• W1878282244 cites W1869429806 @default.
• W1878282244 cites W1990692216 @default.
• W1878282244 cites W1995162751 @default.
• W1878282244 cites W2040220353 @default.
• W1878282244 cites W2073417251 @default.
• W1878282244 cites W2093710070 @default.
• W1878282244 cites W2242224391 @default.
• W1878282244 cites W2340652060 @default.
• W1878282244 cites W27312484 @default.
• W1878282244 cites W277638574 @default.
• W1878282244 cites W68624106 @default.
• W1878282244 cites W75171083 @default.
• W1878282244 doi "https://doi.org/10.1520/jfs16210j" @default.
• W1878282244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9608714" @default.
• W1878282244 hasPublicationYear "1998" @default.
• W1878282244 type Work @default.
• W1878282244 sameAs 1878282244 @default.
• W1878282244 citedByCount "8" @default.
• W1878282244 countsByYear W18782822442014 @default.
• W1878282244 countsByYear W18782822442021 @default.
• W1878282244 crossrefType "journal-article" @default.
• W1878282244 hasAuthorship W1878282244A5041304842 @default.
• W1878282244 hasAuthorship W1878282244A5043499681 @default.
• W1878282244 hasConcept C2777055891 @default.
• W1878282244 hasConcept C2778165595 @default.
• W1878282244 hasConcept C2778716859 @default.
• W1878282244 hasConcept C2780149897 @default.
• W1878282244 hasConcept C42219234 @default.
• W1878282244 hasConcept C71924100 @default.
• W1878282244 hasConceptScore W1878282244C2777055891 @default.
• W1878282244 hasConceptScore W1878282244C2778165595 @default.
• W1878282244 hasConceptScore W1878282244C2778716859 @default.
• W1878282244 hasConceptScore W1878282244C2780149897 @default.
• W1878282244 hasConceptScore W1878282244C42219234 @default.
• W1878282244 hasConceptScore W1878282244C71924100 @default.
• W1878282244 hasIssue "3" @default.
• W1878282244 hasLocation W18782822441 @default.
• W1878282244 hasLocation W18782822442 @default.
• W1878282244 hasOpenAccess W1878282244 @default.
• W1878282244 hasPrimaryLocation W18782822441 @default.
• W1878282244 hasRelatedWork W1567523074 @default.
• W1878282244 hasRelatedWork W1878282244 @default.
• W1878282244 hasRelatedWork W2011930931 @default.
• W1878282244 hasRelatedWork W2053516427 @default.
• W1878282244 hasRelatedWork W2073209744 @default.
• W1878282244 hasRelatedWork W2080740566 @default.
• W1878282244 hasRelatedWork W2355733919 @default.
• W1878282244 hasRelatedWork W2385493891 @default.
• W1878282244 hasRelatedWork W2466729184 @default.
• W1878282244 hasRelatedWork W990497650 @default.
• W1878282244 hasVolume "43" @default.
• W1878282244 isParatext "false" @default.
• W1878282244 isRetracted "false" @default.
• W1878282244 magId "1878282244" @default.
• W1878282244 workType "article" @default.