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- W18783080 abstract "Melatonin (MLT) is rhythmically secreted from the pineal gland and acts on two G protein-coupled receptors, termed MT1 and MT2. Brain tissue from a transgenic mouse line expressing red fluorescence protein (RFP) at the MT1 receptor promoter provides a method of localizing the receptor. RFP-MT1 fluorescence and immunoreactivity was localized to the medial habenula (MHb), habenula commissure (HbC) and the midbrain dorsal medial periaqueductal grey (DMPAG) area. The habenula acts as a relay station from forebrain to midbrain. The downstream PAG plays a prominent role in pain transmission (Behbehani, Prog Neurobiol 1995;46:575–605). The goal of our research is to investigate the distribution of the MT1 receptor in these cholinergic, dopaminergic and glutamatergic neuronal systems. Immunofluorescence co-staining for RFP along with choline acetyl transferase (ChAT), tyrosine hydroxylase (TH) or vesicular glutamate transporter (VGLUT2) is used to investigate the distribution of the MT1 receptor. Results show RFP-MT1 expression in the dorsal MHb, clearly separated from ChAT staining in the ventral MHb. TH colocalized with RFP-MT1 in the HbC, PAG, and the ependymal lining of the aqueduct. VGLUT2 and RFP-MT1 positive cells are present in dorsal MHb neurons. These results indicate a possible role for the MT1 receptor in the modulation of glutamatergic and dopaminergic neurotransmission. Supported by DA 021870 MLD." @default.
- W18783080 created "2016-06-24" @default.
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- W18783080 date "2013-04-01" @default.
- W18783080 modified "2023-09-25" @default.
- W18783080 title "Characterization of MT1 melatonin receptor expressing neurons in the medial habenula, habenula commissure and periaqueductal grey of the C3H/HeN mouse brain" @default.
- W18783080 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1170.2" @default.
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