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• W187831426 abstract "Viable cancer cells can commonly be recovered from surgical sites and venous blood during tumor resection. The adhesion of these cells to surrounding tissues may impact patient outcomes. Iatrogenic exposure to increased extracellular pressure modulates integrin binding affinity and stimulates colon cancer cell adhesion in vitro through an α-actinin-1-dependent signaling pathway. We hypothesized that preoperative small interfering RNA-mediated silencing of α-actinin-1 in tumor tissue could disrupt pressure-stimulated cancer cell adhesion to murine surgical wounds and thereby enhance subsequent tumor-free survival. Reducing α-actinin-1 in CT26 murine adenocarcinoma cells blocked cell adhesion to collagen in vitro and similarly inhibited pressure-induced CT26 implantation in murine surgical wounds in vivo. Surgical wound contamination with pressure-activated CT26 cells significantly reduced tumor-free survival compared to contamination with tumor cells maintained under ambient pressure. However, mice treated with pressure-activated CT26 cells preoperatively transfected with α-actinin-1-specific small interfering RNA displayed reduced surgical site implantation and increased tumor-free survival compared to mice exposed to pressure-activated cells expressing normal levels of α-actinin-1 protein. These results suggest that pressure activation of malignant cells promotes tumor development and impairs tumor-free survival. α-Actinin-1 may be an effective therapeutic target to inhibit perioperative pressure-stimulated tumor cell implantation." @default.
• W187831426 created "2016-06-24" @default.
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• W187831426 date "2008-03-01" @default.
• W187831426 modified "2023-10-17" @default.
• W187831426 title "SiRNA-Mediated Reduction of α-Actinin-1 Inhibits Pressure-Induced Murine Tumor Cell Wound Implantation and Enhances Tumor-Free Survival" @default.
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• W187831426 doi "https://doi.org/10.1593/neo.07945" @default.
• W187831426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2259451" @default.
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