FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878366586> ?p ?o ?g. }

• W1878366586 endingPage "1621" @default.
• W1878366586 startingPage "1612" @default.
• W1878366586 abstract "Voltage-dependent amplification of ionotropic glutamatergic excitatory postsynaptic potentials (EPSPs) can, in many vertebrate neurons, be due either to the intrinsic voltage dependence of N-methyl-d-aspartate (NMDA) receptors, or voltage-dependent persistent sodium channels expressed on postsynaptic dendrites or somata. In the electrosensory lateral line lobe (ELL) of the gymnotiform fish Apteronotus leptorhynchus,glutamatergic inputs onto pyramidal cell apical dendrites provide a system where both amplification mechanisms are possible. We have now examined the roles for both NMDA receptors and sodium channels in the control of EPSP amplitude at these synapses. An antibody specific for the A. leptorhynchus NR1 subunit reacted strongly with ELL pyramidal cells and were particularly abundant in the spines of pyramidal cell apical dendrites. We have also shown that NMDA receptors contributed strongly to the late phase of EPSPs evoked by stimulation of the feedback fibers terminating on the apical dendritic spines; further, these EPSPs were voltage dependent. Blockade of NMDA receptors did not, however, eliminate the voltage dependence of these EPSPs. Blockade of somatic sodium channels by local somatic ejection of tetrodotoxin (TTX), or inclusion of QX314 (an intracellular sodium channel blocker) in the recording pipette, reduced the evoked EPSPs and completely eliminated their voltage dependence. We therefore conclude that, in the subthreshold range, persistent sodium currents are the main contributor to voltage-dependent boosting of EPSPs, even when they have a large NMDA receptor component." @default.
• W1878366586 created "2016-06-24" @default.
• W1878366586 creator A5019782421 @default.
• W1878366586 creator A5046581082 @default.
• W1878366586 creator A5072341048 @default.
• W1878366586 date "2001-10-01" @default.
• W1878366586 modified "2023-10-11" @default.
• W1878366586 title "Function of NMDA Receptors and Persistent Sodium Channels in a Feedback Pathway of the Electrosensory System" @default.
• W1878366586 cites W1500250295 @default.
• W1878366586 cites W1534240399 @default.
• W1878366586 cites W1552487630 @default.
• W1878366586 cites W163811128 @default.
• W1878366586 cites W1652901505 @default.
• W1878366586 cites W1873050758 @default.
• W1878366586 cites W1965729052 @default.
• W1878366586 cites W1976813093 @default.
• W1878366586 cites W1989015514 @default.
• W1878366586 cites W1990625157 @default.
• W1878366586 cites W1991269570 @default.
• W1878366586 cites W1992219804 @default.
• W1878366586 cites W1994320695 @default.
• W1878366586 cites W2016300780 @default.
• W1878366586 cites W2045309328 @default.
• W1878366586 cites W2053980736 @default.
• W1878366586 cites W2057759106 @default.
• W1878366586 cites W2061544984 @default.
• W1878366586 cites W2061652205 @default.
• W1878366586 cites W2065169750 @default.
• W1878366586 cites W2066507418 @default.
• W1878366586 cites W2068881539 @default.
• W1878366586 cites W2073417426 @default.
• W1878366586 cites W2074853678 @default.
• W1878366586 cites W2076453049 @default.
• W1878366586 cites W2093219120 @default.
• W1878366586 cites W2094549318 @default.
• W1878366586 cites W2112256467 @default.
• W1878366586 cites W2134937647 @default.
• W1878366586 cites W2135358145 @default.
• W1878366586 cites W2148901385 @default.
• W1878366586 cites W2159160021 @default.
• W1878366586 cites W2166924410 @default.
• W1878366586 cites W2174044883 @default.
• W1878366586 cites W2179502991 @default.
• W1878366586 cites W2185464566 @default.
• W1878366586 cites W2186287000 @default.
• W1878366586 cites W2213359448 @default.
• W1878366586 cites W2247199836 @default.
• W1878366586 cites W2337604471 @default.
• W1878366586 cites W2399571609 @default.
• W1878366586 cites W2410463265 @default.
• W1878366586 cites W2419365903 @default.
• W1878366586 cites W2471722675 @default.
• W1878366586 cites W4301688647 @default.
• W1878366586 cites W9541871 @default.
• W1878366586 doi "https://doi.org/10.1152/jn.2001.86.4.1612" @default.
• W1878366586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11600624" @default.
• W1878366586 hasPublicationYear "2001" @default.
• W1878366586 type Work @default.
• W1878366586 sameAs 1878366586 @default.
• W1878366586 citedByCount "57" @default.
• W1878366586 countsByYear W18783665862012 @default.
• W1878366586 countsByYear W18783665862013 @default.
• W1878366586 countsByYear W18783665862015 @default.
• W1878366586 countsByYear W18783665862016 @default.
• W1878366586 countsByYear W18783665862017 @default.
• W1878366586 countsByYear W18783665862019 @default.
• W1878366586 countsByYear W18783665862021 @default.
• W1878366586 countsByYear W18783665862022 @default.
• W1878366586 countsByYear W18783665862023 @default.
• W1878366586 crossrefType "journal-article" @default.
• W1878366586 hasAuthorship W1878366586A5019782421 @default.
• W1878366586 hasAuthorship W1878366586A5046581082 @default.
• W1878366586 hasAuthorship W1878366586A5072341048 @default.
• W1878366586 hasConcept C112592302 @default.
• W1878366586 hasConcept C115955781 @default.
• W1878366586 hasConcept C12554922 @default.
• W1878366586 hasConcept C169760540 @default.
• W1878366586 hasConcept C170493617 @default.
• W1878366586 hasConcept C17077164 @default.
• W1878366586 hasConcept C178790620 @default.
• W1878366586 hasConcept C185592680 @default.
• W1878366586 hasConcept C197341189 @default.
• W1878366586 hasConcept C200170125 @default.
• W1878366586 hasConcept C2780648746 @default.
• W1878366586 hasConcept C50952357 @default.
• W1878366586 hasConcept C537181965 @default.
• W1878366586 hasConcept C55493867 @default.
• W1878366586 hasConcept C61174792 @default.
• W1878366586 hasConcept C67018056 @default.
• W1878366586 hasConcept C86803240 @default.
• W1878366586 hasConceptScore W1878366586C112592302 @default.
• W1878366586 hasConceptScore W1878366586C115955781 @default.
• W1878366586 hasConceptScore W1878366586C12554922 @default.
• W1878366586 hasConceptScore W1878366586C169760540 @default.
• W1878366586 hasConceptScore W1878366586C170493617 @default.
• W1878366586 hasConceptScore W1878366586C17077164 @default.
• W1878366586 hasConceptScore W1878366586C178790620 @default.
• W1878366586 hasConceptScore W1878366586C185592680 @default.

• next