Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878371608> ?p ?o ?g. }
- W1878371608 endingPage "435" @default.
- W1878371608 startingPage "432" @default.
- W1878371608 abstract "Abstract Atherosclerosis is an important medical problem of the 21st century, but traditional risk factors could only account for 50% of the problem. Hyperhomocysteinemia is emerging as an independent atherosclerosis risk factor, associated with folate deficiency, renal failure, and relative deficiency of MTHFR (C677T polymorphism) or other enzymes depending on gender, age, and smoking status. Hyperhomocysteinemia has been reported to occur in 11–22% of western people, in 3–5% of normal asymptomatic Chinese subjects aged 18–70 years in Hong Kong, Macau, Sydney, and San Francisco, 23–36% of Chinese in Hong Kong with premature coronary artery disease, and 29% of a nonselective series of coronary subjects in Hong Kong. Evidence is accumulating that documents its associations with atherosclerosis disease in both case-control observations and prospective cohort studies, in vitro experiments, and in vivo experimental models in both animals and human subjects, as well as the successful improvement by homocysteine-lowering of endothelial function as surrogate atherosclerosis endpoints in asymptomatic human and coronary patients (secondary prevention). A number of large scale homocysteine-lowering trials are currently underway for stroke and heart attacks prevention. Collectively these trials will include more than 65,000 patients at high-risk for cardiovascular and stroke events, and should provide a reliable evidence-base for prevention." @default.
- W1878371608 created "2016-06-24" @default.
- W1878371608 creator A5001463476 @default.
- W1878371608 creator A5012287051 @default.
- W1878371608 creator A5015654580 @default.
- W1878371608 creator A5040607821 @default.
- W1878371608 creator A5072430046 @default.
- W1878371608 creator A5081860423 @default.
- W1878371608 creator A5084765833 @default.
- W1878371608 creator A5090961201 @default.
- W1878371608 date "2010-07-12" @default.
- W1878371608 modified "2023-10-16" @default.
- W1878371608 title "FIRST INTERNATIONAL SYMPOSIUM ON CARDIOVASCULAR SCIENCE-FROM BENCH TO BEDSIDE" @default.
- W1878371608 cites W1975357252 @default.
- W1878371608 cites W1993145269 @default.
- W1878371608 cites W1999314744 @default.
- W1878371608 cites W2001322138 @default.
- W1878371608 cites W2010202776 @default.
- W1878371608 cites W2026483758 @default.
- W1878371608 cites W2055703366 @default.
- W1878371608 cites W2084637781 @default.
- W1878371608 cites W2124378690 @default.
- W1878371608 cites W2125756592 @default.
- W1878371608 cites W2159764115 @default.
- W1878371608 cites W2162886683 @default.
- W1878371608 cites W2317172136 @default.
- W1878371608 cites W2342150662 @default.
- W1878371608 doi "https://doi.org/10.1111/j.1540-8191.2001.tb01173.x" @default.
- W1878371608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12630544" @default.
- W1878371608 hasPublicationYear "2010" @default.
- W1878371608 type Work @default.
- W1878371608 sameAs 1878371608 @default.
- W1878371608 citedByCount "15" @default.
- W1878371608 countsByYear W18783716082012 @default.
- W1878371608 countsByYear W18783716082016 @default.
- W1878371608 countsByYear W18783716082018 @default.
- W1878371608 countsByYear W18783716082021 @default.
- W1878371608 crossrefType "journal-article" @default.
- W1878371608 hasAuthorship W1878371608A5001463476 @default.
- W1878371608 hasAuthorship W1878371608A5012287051 @default.
- W1878371608 hasAuthorship W1878371608A5015654580 @default.
- W1878371608 hasAuthorship W1878371608A5040607821 @default.
- W1878371608 hasAuthorship W1878371608A5072430046 @default.
- W1878371608 hasAuthorship W1878371608A5081860423 @default.
- W1878371608 hasAuthorship W1878371608A5084765833 @default.
- W1878371608 hasAuthorship W1878371608A5090961201 @default.
- W1878371608 hasBestOaLocation W18783716081 @default.
- W1878371608 hasConcept C104317684 @default.
- W1878371608 hasConcept C126322002 @default.
- W1878371608 hasConcept C127413603 @default.
- W1878371608 hasConcept C135763542 @default.
- W1878371608 hasConcept C141341695 @default.
- W1878371608 hasConcept C164705383 @default.
- W1878371608 hasConcept C185592680 @default.
- W1878371608 hasConcept C2776523773 @default.
- W1878371608 hasConcept C2777090595 @default.
- W1878371608 hasConcept C2777910003 @default.
- W1878371608 hasConcept C2778213512 @default.
- W1878371608 hasConcept C2779134260 @default.
- W1878371608 hasConcept C2780645631 @default.
- W1878371608 hasConcept C2991716557 @default.
- W1878371608 hasConcept C43563269 @default.
- W1878371608 hasConcept C535046627 @default.
- W1878371608 hasConcept C55493867 @default.
- W1878371608 hasConcept C71924100 @default.
- W1878371608 hasConcept C78519656 @default.
- W1878371608 hasConceptScore W1878371608C104317684 @default.
- W1878371608 hasConceptScore W1878371608C126322002 @default.
- W1878371608 hasConceptScore W1878371608C127413603 @default.
- W1878371608 hasConceptScore W1878371608C135763542 @default.
- W1878371608 hasConceptScore W1878371608C141341695 @default.
- W1878371608 hasConceptScore W1878371608C164705383 @default.
- W1878371608 hasConceptScore W1878371608C185592680 @default.
- W1878371608 hasConceptScore W1878371608C2776523773 @default.
- W1878371608 hasConceptScore W1878371608C2777090595 @default.
- W1878371608 hasConceptScore W1878371608C2777910003 @default.
- W1878371608 hasConceptScore W1878371608C2778213512 @default.
- W1878371608 hasConceptScore W1878371608C2779134260 @default.
- W1878371608 hasConceptScore W1878371608C2780645631 @default.
- W1878371608 hasConceptScore W1878371608C2991716557 @default.
- W1878371608 hasConceptScore W1878371608C43563269 @default.
- W1878371608 hasConceptScore W1878371608C535046627 @default.
- W1878371608 hasConceptScore W1878371608C55493867 @default.
- W1878371608 hasConceptScore W1878371608C71924100 @default.
- W1878371608 hasConceptScore W1878371608C78519656 @default.
- W1878371608 hasIssue "5" @default.
- W1878371608 hasLocation W18783716081 @default.
- W1878371608 hasLocation W18783716082 @default.
- W1878371608 hasOpenAccess W1878371608 @default.
- W1878371608 hasPrimaryLocation W18783716081 @default.
- W1878371608 hasRelatedWork W1491769014 @default.
- W1878371608 hasRelatedWork W1878371608 @default.
- W1878371608 hasRelatedWork W1976692919 @default.
- W1878371608 hasRelatedWork W2012827141 @default.
- W1878371608 hasRelatedWork W2035476262 @default.
- W1878371608 hasRelatedWork W2050271477 @default.
- W1878371608 hasRelatedWork W2100975051 @default.
- W1878371608 hasRelatedWork W2182868765 @default.