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- W1878386564 abstract "Morphogenesis and physiology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate cells and their behaviors, but the relationship between PCP systems has been controversial. We have characterized how the Frizzled and Dachsous-Fat PCP systems are connected through the Spiny-legs isoform of the Prickle-Spiny-legs locus. Two different components of the Dachsous-Fat system, Dachsous and Dachs, can each independently interact with Spiny-legs and direct its localization in vivo. Through characterization of the contributions of Prickle, Spiny-legs, Dachsous, Fat, and Dachs to PCP in the Drosophila wing, eye, and abdomen, we define where Dachs-Spiny-legs and Dachsous-Spiny-legs interactions contribute to PCP, and provide a new understanding of the orientation of polarity and the basis of PCP phenotypes. Our results support the direct linkage of PCP systems through Sple in specific locales, while emphasizing that cells can be subject to and must ultimately resolve distinct, competing PCP signals." @default.
- W1878386564 created "2016-06-24" @default.
- W1878386564 creator A5064249114 @default.
- W1878386564 creator A5071660392 @default.
- W1878386564 date "2015-10-27" @default.
- W1878386564 modified "2023-10-17" @default.
- W1878386564 title "Coordination of planar cell polarity pathways through Spiny-legs" @default.
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- W1878386564 doi "https://doi.org/10.7554/elife.09946" @default.
- W1878386564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764577" @default.
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- W1878386564 hasPublicationYear "2015" @default.
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