FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878386608> ?p ?o ?g. }

• W1878386608 endingPage "1914" @default.
• W1878386608 startingPage "1909" @default.
• W1878386608 abstract "The purpose of this study was to determine if the recently developed novel antimicrobial/antibiofilm agent Next-Science (NS) inhibits biofilm development by Staphylococcus aureus or Pseudomonas aeruginosa on tympanostomy tubes (TT) and to define the concentration of NS at which this inhibition occurs. Preliminary titration experiments determined the effective concentrations of NS that completely inhibit the planktonic growth of S. aureus and P. aeruginosa. Since NS has the potential to inhibit both planktonic growth and biofilm development, we examined the antibiofilm effect using the established concentrations that inhibited planktonic growth. Biofilms developed on TT using the microtiter plate assay were assessed quantitatively by determining the number of microorganisms per tube (CFU/tube) and qualitatively by visualization with confocal laser scanning microscopy (CLSM). Planktonic growth of S. aureus and P. aeruginosa was inhibited by 20.3 μg/mL and 325 μg/mL of NS, respectively. While S. aureus and P. aeruginosa formed well-developed biofilms on TT at 24 h without treatment, addition of the indicated concentrations of NS at the time of inoculation of the TT inhibited the formation of biofilms by both organisms. CLSM confirmed the absence of biofilms on either the inner or outer surface of the treated TTs. At 8 h post-inoculation, P. aeruginosa formed a partial biofilm on the TT when untreated. In comparison, the NS-treated biofilms failed to develop further and the CFU/TT were significantly reduced. The novel antimicrobial agent NS inhibited the development of S. aureus and P. aeruginosa biofilms on TTs. The same concentrations of NS inhibited both planktonic growth and biofilm development." @default.
• W1878386608 created "2016-06-24" @default.
• W1878386608 creator A5011866089 @default.
• W1878386608 creator A5012129166 @default.
• W1878386608 creator A5030338850 @default.
• W1878386608 creator A5034094116 @default.
• W1878386608 creator A5038141680 @default.
• W1878386608 creator A5038786549 @default.
• W1878386608 creator A5042566058 @default.
• W1878386608 date "2015-11-01" @default.
• W1878386608 modified "2023-10-14" @default.
• W1878386608 title "The antimicrobial agent, Next-Science, inhibits the development of Staphylococcus aureus and Pseudomonas aeruginosa biofilms on tympanostomy tubes" @default.
• W1878386608 cites W1604448588 @default.
• W1878386608 cites W1763235239 @default.
• W1878386608 cites W1934109658 @default.
• W1878386608 cites W1966587647 @default.
• W1878386608 cites W1973496190 @default.
• W1878386608 cites W1974173104 @default.
• W1878386608 cites W1984079328 @default.
• W1878386608 cites W2009921154 @default.
• W1878386608 cites W2021401450 @default.
• W1878386608 cites W2043883147 @default.
• W1878386608 cites W2047877569 @default.
• W1878386608 cites W2050162865 @default.
• W1878386608 cites W2057768441 @default.
• W1878386608 cites W2061549314 @default.
• W1878386608 cites W2063496202 @default.
• W1878386608 cites W2065563729 @default.
• W1878386608 cites W2065673455 @default.
• W1878386608 cites W2073828389 @default.
• W1878386608 cites W2077944986 @default.
• W1878386608 cites W2106351298 @default.
• W1878386608 cites W2118620770 @default.
• W1878386608 cites W2123257650 @default.
• W1878386608 cites W2125603952 @default.
• W1878386608 cites W2127535305 @default.
• W1878386608 cites W2135371035 @default.
• W1878386608 cites W2142195904 @default.
• W1878386608 cites W2144894951 @default.
• W1878386608 cites W2150500774 @default.
• W1878386608 cites W2163803918 @default.
• W1878386608 cites W2163870312 @default.
• W1878386608 cites W2169156183 @default.
• W1878386608 cites W2170456981 @default.
• W1878386608 doi "https://doi.org/10.1016/j.ijporl.2015.09.003" @default.
• W1878386608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26388185" @default.
• W1878386608 hasPublicationYear "2015" @default.
• W1878386608 type Work @default.
• W1878386608 sameAs 1878386608 @default.
• W1878386608 citedByCount "5" @default.
• W1878386608 countsByYear W18783866082017 @default.
• W1878386608 countsByYear W18783866082020 @default.
• W1878386608 countsByYear W18783866082022 @default.
• W1878386608 crossrefType "journal-article" @default.
• W1878386608 hasAuthorship W1878386608A5011866089 @default.
• W1878386608 hasAuthorship W1878386608A5012129166 @default.
• W1878386608 hasAuthorship W1878386608A5030338850 @default.
• W1878386608 hasAuthorship W1878386608A5034094116 @default.
• W1878386608 hasAuthorship W1878386608A5038141680 @default.
• W1878386608 hasAuthorship W1878386608A5038786549 @default.
• W1878386608 hasAuthorship W1878386608A5042566058 @default.
• W1878386608 hasConcept C141071460 @default.
• W1878386608 hasConcept C180032290 @default.
• W1878386608 hasConcept C203014093 @default.
• W1878386608 hasConcept C2776439223 @default.
• W1878386608 hasConcept C2777315031 @default.
• W1878386608 hasConcept C2777637488 @default.
• W1878386608 hasConcept C2779489039 @default.
• W1878386608 hasConcept C4937899 @default.
• W1878386608 hasConcept C523546767 @default.
• W1878386608 hasConcept C54355233 @default.
• W1878386608 hasConcept C58123911 @default.
• W1878386608 hasConcept C71924100 @default.
• W1878386608 hasConcept C86803240 @default.
• W1878386608 hasConcept C89423630 @default.
• W1878386608 hasConceptScore W1878386608C141071460 @default.
• W1878386608 hasConceptScore W1878386608C180032290 @default.
• W1878386608 hasConceptScore W1878386608C203014093 @default.
• W1878386608 hasConceptScore W1878386608C2776439223 @default.
• W1878386608 hasConceptScore W1878386608C2777315031 @default.
• W1878386608 hasConceptScore W1878386608C2777637488 @default.
• W1878386608 hasConceptScore W1878386608C2779489039 @default.
• W1878386608 hasConceptScore W1878386608C4937899 @default.
• W1878386608 hasConceptScore W1878386608C523546767 @default.
• W1878386608 hasConceptScore W1878386608C54355233 @default.
• W1878386608 hasConceptScore W1878386608C58123911 @default.
• W1878386608 hasConceptScore W1878386608C71924100 @default.
• W1878386608 hasConceptScore W1878386608C86803240 @default.
• W1878386608 hasConceptScore W1878386608C89423630 @default.
• W1878386608 hasIssue "11" @default.
• W1878386608 hasLocation W18783866081 @default.
• W1878386608 hasLocation W18783866082 @default.
• W1878386608 hasOpenAccess W1878386608 @default.
• W1878386608 hasPrimaryLocation W18783866081 @default.
• W1878386608 hasRelatedWork W1878386608 @default.
• W1878386608 hasRelatedWork W1989452115 @default.
• W1878386608 hasRelatedWork W2114842640 @default.
• W1878386608 hasRelatedWork W2156716055 @default.

• next