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- W1878416402 endingPage "1999" @default.
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- W1878416402 abstract "Efficient transcription and replication of the bovine leukemia virus (BLV) genome require both the viral long terminal repeat (LTR) and the virus-coded transcriptional activator Tax, which functions through a 21-bp sequence (Tax-responsive element [TxRE]) which is repeated three times within the LTR. Since Tax does not bind directly to DNA, host cell transcription factors play a central role in BLV expression. Electrophoretic mobility shift assays with nuclear extracts prepared with infected bovine B lymphocytes revealed five TxRE-specific complexes (C1, C2, C3, C4, and C5). Here, by using a UV-induced indirect labeling technique (UV cross-linking) in conjunction with mobility shift assays, eight major polypeptides of 31, 33, 42, 46, 51, 57, 87, and 119 kDa were identified within these five complexes. Immunoprecipitation experiments identified the 57- and 119-kDa proteins as cyclic AMP response element-binding (CREB) proteins, the 46- and 51-kDa proteins as activating transcription factor-1 (ATF-1), and the 87-kDa as protein ATF-2. All of these proteins (except the ATF-1 protein of 51 kDa) belong to the complex C1, which is the major complex identified in freshly isolated BLV-infected lymphocytes from cattle with persistent lymphocytosis. In transient-cotransfection experiments, these three transcription factors were able to activate LTR-directed gene expression in the presence of protein kinase A or Ca2+/calmodulin-dependent protein kinase IV. CREB protein, ATF-1, and ATF-2 thus appear to be the major transcription factors involved in the early stages of viral expression." @default.
- W1878416402 created "2016-06-24" @default.
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- W1878416402 date "1996-03-01" @default.
- W1878416402 modified "2023-10-06" @default.
- W1878416402 title "The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression" @default.
- W1878416402 cites W1495237614 @default.
- W1878416402 cites W1510204992 @default.
- W1878416402 cites W1521650943 @default.
- W1878416402 cites W1523614100 @default.
- W1878416402 cites W1539006922 @default.
- W1878416402 cites W1544182255 @default.
- W1878416402 cites W1580590749 @default.
- W1878416402 cites W1596088269 @default.
- W1878416402 cites W1660255712 @default.
- W1878416402 cites W1695574112 @default.
- W1878416402 cites W1829993289 @default.
- W1878416402 cites W1849423995 @default.
- W1878416402 cites W1865665406 @default.
- W1878416402 cites W1887488204 @default.
- W1878416402 cites W1900462606 @default.
- W1878416402 cites W1951047070 @default.
- W1878416402 cites W1955037330 @default.
- W1878416402 cites W1956800078 @default.
- W1878416402 cites W1958327809 @default.
- W1878416402 cites W1964396828 @default.
- W1878416402 cites W1965609745 @default.
- W1878416402 cites W1972797149 @default.
- W1878416402 cites W1973135307 @default.
- W1878416402 cites W1980166477 @default.
- W1878416402 cites W1981083554 @default.
- W1878416402 cites W1985223341 @default.
- W1878416402 cites W2000024512 @default.
- W1878416402 cites W2000090884 @default.
- W1878416402 cites W2000324336 @default.
- W1878416402 cites W2001692359 @default.
- W1878416402 cites W2008295169 @default.
- W1878416402 cites W2011509827 @default.
- W1878416402 cites W2019586219 @default.
- W1878416402 cites W2025776317 @default.
- W1878416402 cites W2028242823 @default.
- W1878416402 cites W2033265652 @default.
- W1878416402 cites W2036145275 @default.
- W1878416402 cites W2039871973 @default.
- W1878416402 cites W2042976701 @default.
- W1878416402 cites W2049496770 @default.
- W1878416402 cites W2050999934 @default.
- W1878416402 cites W2064087386 @default.
- W1878416402 cites W2068877244 @default.
- W1878416402 cites W2070697949 @default.
- W1878416402 cites W2071140879 @default.
- W1878416402 cites W2077088537 @default.
- W1878416402 cites W2077448050 @default.
- W1878416402 cites W2077486511 @default.
- W1878416402 cites W2078962110 @default.
- W1878416402 cites W2080486926 @default.
- W1878416402 cites W2081704409 @default.
- W1878416402 cites W2085174657 @default.
- W1878416402 cites W2089621556 @default.
- W1878416402 cites W2099942088 @default.
- W1878416402 cites W2109399660 @default.
- W1878416402 cites W2116567102 @default.
- W1878416402 cites W2120594463 @default.
- W1878416402 cites W2122873742 @default.
- W1878416402 cites W2123194197 @default.
- W1878416402 cites W2124793035 @default.
- W1878416402 cites W2124885959 @default.
- W1878416402 cites W2126440278 @default.
- W1878416402 cites W2133358800 @default.
- W1878416402 cites W2136210811 @default.
- W1878416402 cites W2141148106 @default.
- W1878416402 cites W2145085539 @default.
- W1878416402 cites W2145330934 @default.
- W1878416402 cites W2146305933 @default.
- W1878416402 cites W2153724035 @default.
- W1878416402 cites W2164180561 @default.
- W1878416402 cites W2291015287 @default.
- W1878416402 cites W2326728045 @default.
- W1878416402 cites W2346838637 @default.
- W1878416402 cites W2396857414 @default.
- W1878416402 cites W2418547565 @default.
- W1878416402 cites W2438919149 @default.
- W1878416402 cites W2462342909 @default.
- W1878416402 cites W267870743 @default.
- W1878416402 cites W315180324 @default.
- W1878416402 cites W3157412025 @default.
- W1878416402 doi "https://doi.org/10.1128/jvi.70.3.1990-1999.1996" @default.
- W1878416402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190028" @default.
- W1878416402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8627725" @default.
- W1878416402 hasPublicationYear "1996" @default.
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