Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878446582> ?p ?o ?g. }
- W1878446582 endingPage "379" @default.
- W1878446582 startingPage "369" @default.
- W1878446582 abstract "cDNA clones for the human laminin A chain were isolated from libraries prepared from human gestational choriocarcinoma cell line (JAR) RNA. They cover approx. 8 kb from the 5′-end of the 9.5 kb mRNA coding for this protein. Our clones contain 94 nucleotide residues for the 5′-end untranslated region and 7885 nucleotide residues of coding sequence. The complete human laminin A chain contains a 17-amino acid-residue signal peptide and a 3058-residue A chain proper. The human laminin A chain has a distinct domain structure with numerous internal cysteine-rich repeats. The large globular domain G has five repeats, which have several conserved glycine and cysteine residues. Furthermore the A chain contains 20 internal cysteine-rich repeats present in tandem arrays in three separate clusters (domains IIIa, IIIb and V). Domain I + II has a predicted continuous alpha-helical structure characterized by heptad repeats and three domains (IVa, IVb and VI) are predicted to contain a number of beta-sheets and coiled-coil structures. Northern-blot analysis was used to study the laminin A chain expression in the JAR cell line, full-term placenta and newborn-human tissues (kidney, spleen, lung, heart muscle, psoas muscle and diaphragm muscle). The expression was detectable in newborn-human kidney and JAR cell line only. The overall amino acid sequence identity between human and mouse is 76%. The human chain has only one Arg-Gly-Asp (RGD) sequence, which is located in the long arm within domain G, whereas the single RGD sequence in the mouse chain is located in the short arm in domain IIIb. The degree of identity between the human laminin A chain sequence and the sequence available for merosin [Ehrig, Leivo, Argraves, Ruoslahti & Engvall (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 3264-3268] is about 41% and when conservative substitutions are included the degree of similarity is 54%." @default.
- W1878446582 created "2016-06-24" @default.
- W1878446582 creator A5000224317 @default.
- W1878446582 creator A5011433642 @default.
- W1878446582 creator A5041845619 @default.
- W1878446582 creator A5078585798 @default.
- W1878446582 creator A5088423759 @default.
- W1878446582 date "1991-06-01" @default.
- W1878446582 modified "2023-10-17" @default.
- W1878446582 title "Primary structure of the human laminin A chain. Limited expression in human tissues" @default.
- W1878446582 cites W1481375874 @default.
- W1878446582 cites W148576069 @default.
- W1878446582 cites W1485908731 @default.
- W1878446582 cites W1493333437 @default.
- W1878446582 cites W1552674921 @default.
- W1878446582 cites W1560452279 @default.
- W1878446582 cites W1567770297 @default.
- W1878446582 cites W1569253487 @default.
- W1878446582 cites W1572837727 @default.
- W1878446582 cites W157395064 @default.
- W1878446582 cites W1593606055 @default.
- W1878446582 cites W1597094163 @default.
- W1878446582 cites W1604993705 @default.
- W1878446582 cites W1628719417 @default.
- W1878446582 cites W1966034730 @default.
- W1878446582 cites W1967888499 @default.
- W1878446582 cites W1970799392 @default.
- W1878446582 cites W1973064020 @default.
- W1878446582 cites W1975986023 @default.
- W1878446582 cites W1982211206 @default.
- W1878446582 cites W1993352932 @default.
- W1878446582 cites W1995797967 @default.
- W1878446582 cites W2005165360 @default.
- W1878446582 cites W2013771439 @default.
- W1878446582 cites W2017227679 @default.
- W1878446582 cites W2020555116 @default.
- W1878446582 cites W2038360740 @default.
- W1878446582 cites W2041854819 @default.
- W1878446582 cites W2046580700 @default.
- W1878446582 cites W2052728159 @default.
- W1878446582 cites W2053269420 @default.
- W1878446582 cites W2061344286 @default.
- W1878446582 cites W2078143267 @default.
- W1878446582 cites W2085566447 @default.
- W1878446582 cites W2091970430 @default.
- W1878446582 cites W2116497667 @default.
- W1878446582 cites W2126741390 @default.
- W1878446582 cites W2134812217 @default.
- W1878446582 cites W2138270253 @default.
- W1878446582 cites W2155619649 @default.
- W1878446582 cites W2166703723 @default.
- W1878446582 cites W2467704015 @default.
- W1878446582 cites W88723889 @default.
- W1878446582 doi "https://doi.org/10.1042/bj2760369" @default.
- W1878446582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1151101" @default.
- W1878446582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2049067" @default.
- W1878446582 hasPublicationYear "1991" @default.
- W1878446582 type Work @default.
- W1878446582 sameAs 1878446582 @default.
- W1878446582 citedByCount "104" @default.
- W1878446582 countsByYear W18784465822015 @default.
- W1878446582 countsByYear W18784465822016 @default.
- W1878446582 countsByYear W18784465822018 @default.
- W1878446582 countsByYear W18784465822020 @default.
- W1878446582 countsByYear W18784465822021 @default.
- W1878446582 countsByYear W18784465822022 @default.
- W1878446582 crossrefType "journal-article" @default.
- W1878446582 hasAuthorship W1878446582A5000224317 @default.
- W1878446582 hasAuthorship W1878446582A5011433642 @default.
- W1878446582 hasAuthorship W1878446582A5041845619 @default.
- W1878446582 hasAuthorship W1878446582A5078585798 @default.
- W1878446582 hasAuthorship W1878446582A5088423759 @default.
- W1878446582 hasBestOaLocation W18784465822 @default.
- W1878446582 hasConcept C104317684 @default.
- W1878446582 hasConcept C10858879 @default.
- W1878446582 hasConcept C153911025 @default.
- W1878446582 hasConcept C167625842 @default.
- W1878446582 hasConcept C187882448 @default.
- W1878446582 hasConcept C189165786 @default.
- W1878446582 hasConcept C2779814568 @default.
- W1878446582 hasConcept C55493867 @default.
- W1878446582 hasConcept C84148353 @default.
- W1878446582 hasConcept C86803240 @default.
- W1878446582 hasConcept C91779695 @default.
- W1878446582 hasConcept C92825506 @default.
- W1878446582 hasConceptScore W1878446582C104317684 @default.
- W1878446582 hasConceptScore W1878446582C10858879 @default.
- W1878446582 hasConceptScore W1878446582C153911025 @default.
- W1878446582 hasConceptScore W1878446582C167625842 @default.
- W1878446582 hasConceptScore W1878446582C187882448 @default.
- W1878446582 hasConceptScore W1878446582C189165786 @default.
- W1878446582 hasConceptScore W1878446582C2779814568 @default.
- W1878446582 hasConceptScore W1878446582C55493867 @default.
- W1878446582 hasConceptScore W1878446582C84148353 @default.
- W1878446582 hasConceptScore W1878446582C86803240 @default.
- W1878446582 hasConceptScore W1878446582C91779695 @default.
- W1878446582 hasConceptScore W1878446582C92825506 @default.
- W1878446582 hasIssue "2" @default.