Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878461193> ?p ?o ?g. }
- W1878461193 endingPage "7096" @default.
- W1878461193 startingPage "7092" @default.
- W1878461193 abstract "Tip of herpesvirus saimiri associates with Lck and downregulates Lck function in cellular signal transduction. In this report, we demonstrate that mutation of tyrosine 114 of Tip significantly increases Lck-binding activity. This mutant exhibits a dramatic increase in the suppression of cellular tyrosine phosphorylation and surface expression of lymphocyte antigens in comparison with wild-type Tip. In addition, the expression of TipY114 converted the transforming morphology of fibroblasts induced by oncogenic F505 Lck to a normal cellular morphology. These results further support a mechanism by which the association of Tip with Lck negatively regulates Lck-mediated signal transduction." @default.
- W1878461193 created "2016-06-24" @default.
- W1878461193 creator A5000479471 @default.
- W1878461193 creator A5003819949 @default.
- W1878461193 creator A5024461673 @default.
- W1878461193 creator A5042777948 @default.
- W1878461193 creator A5048559686 @default.
- W1878461193 creator A5059300419 @default.
- W1878461193 creator A5067689954 @default.
- W1878461193 date "1997-09-01" @default.
- W1878461193 modified "2023-10-17" @default.
- W1878461193 title "Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip" @default.
- W1878461193 cites W1501401884 @default.
- W1878461193 cites W1509673417 @default.
- W1878461193 cites W1534165148 @default.
- W1878461193 cites W1562890011 @default.
- W1878461193 cites W1756788915 @default.
- W1878461193 cites W1872701945 @default.
- W1878461193 cites W1910404793 @default.
- W1878461193 cites W1952338120 @default.
- W1878461193 cites W1971855594 @default.
- W1878461193 cites W1988687391 @default.
- W1878461193 cites W1993546845 @default.
- W1878461193 cites W2000086986 @default.
- W1878461193 cites W2008177711 @default.
- W1878461193 cites W2029275833 @default.
- W1878461193 cites W2032438721 @default.
- W1878461193 cites W2035562653 @default.
- W1878461193 cites W2040516035 @default.
- W1878461193 cites W2042373385 @default.
- W1878461193 cites W2042891038 @default.
- W1878461193 cites W2051132730 @default.
- W1878461193 cites W2063227295 @default.
- W1878461193 cites W2100903140 @default.
- W1878461193 cites W2114582926 @default.
- W1878461193 cites W2128390413 @default.
- W1878461193 cites W2154772843 @default.
- W1878461193 cites W216444324 @default.
- W1878461193 cites W2166032271 @default.
- W1878461193 cites W2414570508 @default.
- W1878461193 cites W2755960609 @default.
- W1878461193 doi "https://doi.org/10.1128/jvi.71.9.7092-7096.1997" @default.
- W1878461193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/192003" @default.
- W1878461193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9261442" @default.
- W1878461193 hasPublicationYear "1997" @default.
- W1878461193 type Work @default.
- W1878461193 sameAs 1878461193 @default.
- W1878461193 citedByCount "31" @default.
- W1878461193 countsByYear W18784611932012 @default.
- W1878461193 countsByYear W18784611932015 @default.
- W1878461193 crossrefType "journal-article" @default.
- W1878461193 hasAuthorship W1878461193A5000479471 @default.
- W1878461193 hasAuthorship W1878461193A5003819949 @default.
- W1878461193 hasAuthorship W1878461193A5024461673 @default.
- W1878461193 hasAuthorship W1878461193A5042777948 @default.
- W1878461193 hasAuthorship W1878461193A5048559686 @default.
- W1878461193 hasAuthorship W1878461193A5059300419 @default.
- W1878461193 hasAuthorship W1878461193A5067689954 @default.
- W1878461193 hasBestOaLocation W18784611931 @default.
- W1878461193 hasConcept C104317684 @default.
- W1878461193 hasConcept C11960822 @default.
- W1878461193 hasConcept C127561419 @default.
- W1878461193 hasConcept C143065580 @default.
- W1878461193 hasConcept C2776165026 @default.
- W1878461193 hasConcept C2777553839 @default.
- W1878461193 hasConcept C42362537 @default.
- W1878461193 hasConcept C501734568 @default.
- W1878461193 hasConcept C54355233 @default.
- W1878461193 hasConcept C55493867 @default.
- W1878461193 hasConcept C62478195 @default.
- W1878461193 hasConcept C85528070 @default.
- W1878461193 hasConcept C86803240 @default.
- W1878461193 hasConcept C95444343 @default.
- W1878461193 hasConceptScore W1878461193C104317684 @default.
- W1878461193 hasConceptScore W1878461193C11960822 @default.
- W1878461193 hasConceptScore W1878461193C127561419 @default.
- W1878461193 hasConceptScore W1878461193C143065580 @default.
- W1878461193 hasConceptScore W1878461193C2776165026 @default.
- W1878461193 hasConceptScore W1878461193C2777553839 @default.
- W1878461193 hasConceptScore W1878461193C42362537 @default.
- W1878461193 hasConceptScore W1878461193C501734568 @default.
- W1878461193 hasConceptScore W1878461193C54355233 @default.
- W1878461193 hasConceptScore W1878461193C55493867 @default.
- W1878461193 hasConceptScore W1878461193C62478195 @default.
- W1878461193 hasConceptScore W1878461193C85528070 @default.
- W1878461193 hasConceptScore W1878461193C86803240 @default.
- W1878461193 hasConceptScore W1878461193C95444343 @default.
- W1878461193 hasIssue "9" @default.
- W1878461193 hasLocation W18784611931 @default.
- W1878461193 hasLocation W18784611932 @default.
- W1878461193 hasLocation W18784611933 @default.
- W1878461193 hasLocation W18784611934 @default.
- W1878461193 hasOpenAccess W1878461193 @default.
- W1878461193 hasPrimaryLocation W18784611931 @default.
- W1878461193 hasRelatedWork W1580168755 @default.
- W1878461193 hasRelatedWork W1987307749 @default.
- W1878461193 hasRelatedWork W2006626122 @default.
- W1878461193 hasRelatedWork W2027995286 @default.