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• W1878496410 abstract "Parosteal osteoid sarcoma, sometimes referred to as“juxtacortical osteogenic sarcoma”, is a rare malignant bone tumor which must be differentiated from an osteosarcoma clinically, roentgenologically, and histologically. Its relatively benign course was described by Müller as early as 1843 (13), but it was not before 1947 that parosteal osteoid sarcoma, representing only 1 per cent of all bone tumors, was recognized as a distinct and separate entity (9). This tumor occurs most frequently in the third and fourth decades of life and is without sex predilection. It involves the large cylindrical bones of the extremities, predominantly the metaphysis (Fig. 1). The distal femur is affected most often. The tumor usually presents a palpable hard mass which does not adhere to the skin. It is frequently associated with pain and limitation of motion. Symptoms may have been present for months or even years. All parosteal osteoid sarcomas are basically malignant tumors (Fig. 2) which if untreated eventually metastasize, usually to the lungs, and result in death. An outstanding feature is their clinical behavior: they are characterized by slow growth and cure can be expected in 60 to 70 per cent if proper treatment is instituted. Such treatment consists of either extensive local resection or amputation. While the choice of local resection or amputation frequently is made by mechanical or prosthetic considerations, it could also be influenced by an estimate of the degree of malignancy of the tumor. Therefore, it would be important to be able to determine the pathological stage of the tumor. As the tumor frequently is progressively aggressive, incomplete local resection may generate an invasive potentiality with subsequent metastases. Histologically, centers of irregular ossification are interposed with atypical spindle-shaped proliferating cells. In the periphery, areas of fibrous stroma contain osteoid tissue with ossification of variable degree intermixed with cartilaginous material. Radiographically, the tumor appears as a partially calcified mass arising in the vicinity of the periosteum invading the soft tissue. Since there is no differentiation of the neoplastic bone within the tumor into recognized trabeculae, it tends to be uniformly dense and opaque, although foci of opacity may be scattered throughout the mass. The periphery of the tumor is sharply delineated as a rule. In some cases, an indistinct mass may extend into surrounding soft tissue, representing unossified or poorly ossified osteoid tissue. The more dense and uniform the ossification, the less the tendency of the tumor to rapid and infiltrating growth. Broad areas of nonossification across the mass make one suspect a malignant course. There is no elevation of the periosteum ; the growing tumor surrounds the bone, leaving a soft-tissue space between cortex and tumor (Fig. 3). In the early stages, the cortex is only rarely eroded." @default.
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• W1878496410 date "1966-04-01" @default.
• W1878496410 modified "2023-09-23" @default.
• W1878496410 title "Parosteal Osteoid Sarcoma" @default.
• W1878496410 doi "https://doi.org/10.1148/86.4.648" @default.
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