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- W1878705459 abstract "Publisher Summary This chapter describes the various aspects of antihypertensive drugs. The landscape of hypertension management has changed considerably, and changes in treatment are reviewed every few years by national and international groups with interests in cardiovascular disease. The overall incidence of drug-induced angioedema is not known, but it is estimated that it could occur in 0.1–0.5% of patients taking ACE inhibitors. In a prospective placebo-controlled study in 12557 patients with hypertension treated with enalapril maleate 5–40 mg/day, angioedema occurred in 86. The pathophysiological mechanism has been related to bradykinin accumulation, release of IgE, and mast cell-mediated release of vasoactive mediators. The immunoglobulin E antibodies or other specific antibodies have not been detected. The angiotensin receptor antagonists losartan, irbesartan, telmisartan, eprosartan, and valsartan have all also been implicated, and they are not necessarily absolute safe substitutes for patients with ACE inhibitor-induced angioedema. Pancreatitis has been reported with ACE inhibitors, and a case has been reported in a patient taking lisinopril and hydrochlorothiazide." @default.
- W1878705459 created "2016-06-24" @default.
- W1878705459 creator A5043389395 @default.
- W1878705459 date "2007-01-01" @default.
- W1878705459 modified "2023-09-25" @default.
- W1878705459 title "20 Antihypertensive drugs" @default.
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