Matches in SemOpenAlex for { <https://semopenalex.org/work/W1878773612> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1878773612 endingPage "33" @default.
- W1878773612 startingPage "25" @default.
- W1878773612 abstract "We examined the ability of human peripheral blood leukocytes to kill strains of Shigella sonnei and Shigella flexneri by using a modified bactericidal assay. Antibody-dependent cellular cytotoxicity (ADCC) was demonstrated in the presence of specific rabbit immune serum directed against S. sonnei. With peripheral blood leukocytes from adults, ADCC was found only in the mononuclear cell and purified lymphocyte populations. Monocyte-macrophages and polymorphonuclear leukocytes were unable to demonstrate ADCC. Lymphocyte ADCC, which was not affected by the addition of phenylbutazone (an inhibitor of phagocytosis), was mediated by a non-T, Fc receptor-positive, HNK-1- cell. ADCC (using antiserum directed against virulent S. sonnei) was demonstrated against virulent S. sonnei but not against virulent S. sonnei or virulent S. flexneri. In contrast to leukocytes from adults, both mononuclear and polymorphonuclear cells from neonatal cord blood and from a patient with chronic granulomatous disease mediated anti-Shigella ADCC. Breast milk leukocytes (BMLs) collected 1 to 3 days postpartum were used as effector cells against virulent S. sonnei. The entire BML population, BMLs which did not adhere to plastic and BMLs which passed through nylon wool columns mediated both natural killer cytotoxicity and ADCC. In paired experiments, natural killer cytotoxicity and ADCC were significantly lower (30 to 45% inhibition) but not ablated, when phenylbutazone was added to BMLs and nylon wool-purified BMLs (P less than 0.05). These experiments suggest that colostral leukocytes mediated both extracellular and intracellular bacteriolysis in the presence and absence of specific antiserum. These mechanisms may be active in vivo in protection against shigellosis." @default.
- W1878773612 created "2016-06-24" @default.
- W1878773612 creator A5000289625 @default.
- W1878773612 creator A5022890061 @default.
- W1878773612 creator A5062373564 @default.
- W1878773612 creator A5084368441 @default.
- W1878773612 date "1984-10-01" @default.
- W1878773612 modified "2023-10-14" @default.
- W1878773612 title "Cytotoxicity of human peripheral blood and colostral leukocytes against Shigella species" @default.
- W1878773612 cites W129845289 @default.
- W1878773612 cites W1818122610 @default.
- W1878773612 cites W1938006094 @default.
- W1878773612 cites W1952575201 @default.
- W1878773612 cites W1974035168 @default.
- W1878773612 cites W1974965632 @default.
- W1878773612 cites W1990349686 @default.
- W1878773612 cites W2012819400 @default.
- W1878773612 cites W2019385731 @default.
- W1878773612 cites W2029883496 @default.
- W1878773612 cites W2050278198 @default.
- W1878773612 cites W2057068012 @default.
- W1878773612 cites W2062695479 @default.
- W1878773612 cites W2067155969 @default.
- W1878773612 cites W2083218763 @default.
- W1878773612 cites W2084093106 @default.
- W1878773612 cites W2086994939 @default.
- W1878773612 cites W2107727063 @default.
- W1878773612 cites W2113629715 @default.
- W1878773612 cites W2121243970 @default.
- W1878773612 cites W2124823452 @default.
- W1878773612 cites W2154507894 @default.
- W1878773612 cites W2156226164 @default.
- W1878773612 cites W2161187051 @default.
- W1878773612 cites W2314357194 @default.
- W1878773612 cites W2316421596 @default.
- W1878773612 cites W2327377968 @default.
- W1878773612 cites W2329733885 @default.
- W1878773612 cites W2478145278 @default.
- W1878773612 cites W2486903874 @default.
- W1878773612 doi "https://doi.org/10.1128/iai.46.1.25-33.1984" @default.
- W1878773612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/261416" @default.
- W1878773612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6384045" @default.
- W1878773612 hasPublicationYear "1984" @default.
- W1878773612 type Work @default.
- W1878773612 sameAs 1878773612 @default.
- W1878773612 citedByCount "30" @default.
- W1878773612 countsByYear W18787736122016 @default.
- W1878773612 countsByYear W18787736122019 @default.
- W1878773612 countsByYear W18787736122020 @default.
- W1878773612 crossrefType "journal-article" @default.
- W1878773612 hasAuthorship W1878773612A5000289625 @default.
- W1878773612 hasAuthorship W1878773612A5022890061 @default.
- W1878773612 hasAuthorship W1878773612A5062373564 @default.
- W1878773612 hasAuthorship W1878773612A5084368441 @default.
- W1878773612 hasBestOaLocation W18787736121 @default.
- W1878773612 hasConcept C137061746 @default.
- W1878773612 hasConcept C159654299 @default.
- W1878773612 hasConcept C160448771 @default.
- W1878773612 hasConcept C202751555 @default.
- W1878773612 hasConcept C203014093 @default.
- W1878773612 hasConcept C2777761686 @default.
- W1878773612 hasConcept C40677261 @default.
- W1878773612 hasConcept C542903549 @default.
- W1878773612 hasConcept C55493867 @default.
- W1878773612 hasConcept C86803240 @default.
- W1878773612 hasConcept C89423630 @default.
- W1878773612 hasConceptScore W1878773612C137061746 @default.
- W1878773612 hasConceptScore W1878773612C159654299 @default.
- W1878773612 hasConceptScore W1878773612C160448771 @default.
- W1878773612 hasConceptScore W1878773612C202751555 @default.
- W1878773612 hasConceptScore W1878773612C203014093 @default.
- W1878773612 hasConceptScore W1878773612C2777761686 @default.
- W1878773612 hasConceptScore W1878773612C40677261 @default.
- W1878773612 hasConceptScore W1878773612C542903549 @default.
- W1878773612 hasConceptScore W1878773612C55493867 @default.
- W1878773612 hasConceptScore W1878773612C86803240 @default.
- W1878773612 hasConceptScore W1878773612C89423630 @default.
- W1878773612 hasIssue "1" @default.
- W1878773612 hasLocation W18787736121 @default.
- W1878773612 hasLocation W18787736122 @default.
- W1878773612 hasLocation W18787736123 @default.
- W1878773612 hasOpenAccess W1878773612 @default.
- W1878773612 hasPrimaryLocation W18787736121 @default.
- W1878773612 hasRelatedWork W1963767522 @default.
- W1878773612 hasRelatedWork W2011324112 @default.
- W1878773612 hasRelatedWork W2041538272 @default.
- W1878773612 hasRelatedWork W204820216 @default.
- W1878773612 hasRelatedWork W2058390135 @default.
- W1878773612 hasRelatedWork W2065298785 @default.
- W1878773612 hasRelatedWork W2396057067 @default.
- W1878773612 hasRelatedWork W2403627752 @default.
- W1878773612 hasRelatedWork W2416548179 @default.
- W1878773612 hasRelatedWork W34744360 @default.
- W1878773612 hasVolume "46" @default.
- W1878773612 isParatext "false" @default.
- W1878773612 isRetracted "false" @default.
- W1878773612 magId "1878773612" @default.
- W1878773612 workType "article" @default.