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• W1878858958 abstract "Carmen Fioravanti, Advisor At specific intervals, increased concentrations of two steroid hormones, i.e., ecdysone (E) and 20-hydroxyecdysone (20E), elicit developmental changes in arthropods. Conversion of E to the active molting hormone, 20E, in the tobacco hornworm Manduca sexta is catalyzed by the cytochrome P450-containing ecdysone 20-monooxygenase system (E20M). During embryogenesis, M. sexta E20M activity increased for the first 72 hours at which time it peaked and subsequently significantly declined. The increased activity coincided with the increase of free ecdysteroids and the progression of two embryonic molts. In midgut tissue of fifth instar M. sexta, decreases in second messenger 3’,5’cyclic guanosine monophosphate (cGMP) concentration inhibited day five E20M activity, but increases in cGMP concentration restored E20M activity. Midgut cGMP content peaked on day five of the instar in concert with the highest level of E20M activity observed. Molecular studies with midgut tissue demonstrated that the E agonist RH-5849 elicited increases in E20M (the shade gene) expression. In the presence of two guanylate cyclase inhibitors, E20M expression significantly increased. Inhibition remediation by pharmacological means resulted in significantly decreased shade expression. While it is unclear as to where cGMP exerts its effects on E20M activity, the data indicated that the second messenger affected the level of transcription, translation, or enzyme activity either individually or in some combination. Interestingly, E20M activity also was found to be affected by six synthesized anthraquinones suggesting that these compounds can serve to" @default.
• W1878858958 created "2016-06-24" @default.
• W1878858958 creator A5066033680 @default.
• W1878858958 date "2011-01-01" @default.
• W1878858958 modified "2023-09-27" @default.
• W1878858958 title "Regulation of Ecdysone 20-Monooxygenase Activity in the Tobacco Hornworm, Manduca sexta and the Apparent Occurrence of this Activity in Ascaris suum (Nematoda)" @default.
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