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• W1878991695 abstract "Rheumatoid arthritis (RA) is a heterogeneous disease with a complex and yet not fully understood pathophysiology, where numerous different cell-types contribute to a destructive process of the joints. This complexity results into a considerable interpatient variability in clinical course and severity, which may additionally involve genetics and/or environmental factors. After three decades of focused efforts scientists have now achieved to apply in clinical practice, for patients with RA, the “treat to target” approach with initiation of aggressive therapy soon after diagnosis and escalation of the therapy in pursuit of clinical remission. In addition to the conventional synthetic disease modifying anti-rheumatic drugs, biologics have greatly improved the management of RA, demonstrating efficacy and safety in alleviating symptoms, inhibiting bone erosion, and preventing loss of function. Nonetheless, despite the plethora of therapeutic options and their combinations, unmet therapeutic needs in RA remain, as current therapies sometimes fail or produce only partial responses and/or develop unwanted side-effects. Unfortunately the mechanisms of ‘nonresponse’ remain unknown and most probable lie in the unrevealed heterogeneity of the RA pathophysiology. In this review, through the effort of unraveling the complex pathophysiological pathways, we will depict drugs used throughout the years for the treatment of RA, the current and future biological therapies and their molecular or cellular targets and finally will suggest therapeutic algorithms for RA management. With multiple biologic options, there is still a need for strong predictive biomarkers to determine which drug is most likely to be effective, safe, and durable in a given individual. The fact that available biologics are not effective in all patients attests to the heterogeneity of RA, yet over the long term, as research and treatment become more aggressive, efficacy, toxicity, and costs must be balanced within the therapeutic equation to enhance the quality of life in patients with RA." @default.
• W1878991695 created "2016-06-24" @default.
• W1878991695 creator A5033228211 @default.
• W1878991695 creator A5059993695 @default.
• W1878991695 creator A5082548810 @default.
• W1878991695 date "2015-12-01" @default.
• W1878991695 modified "2023-09-27" @default.
• W1878991695 title "Treatment of rheumatoid arthritis: Unraveling the conundrum" @default.
• W1878991695 cites W132781887 @default.
• W1878991695 cites W1507322431 @default.
• W1878991695 cites W1524209515 @default.
• W1878991695 cites W1555919277 @default.
• W1878991695 cites W1566187667 @default.
• W1878991695 cites W1587015012 @default.
• W1878991695 cites W1608734376 @default.
• W1878991695 cites W1613884642 @default.
• W1878991695 cites W1761300068 @default.
• W1878991695 cites W1921974465 @default.
• W1878991695 cites W1966756501 @default.
• W1878991695 cites W1967576031 @default.
• W1878991695 cites W1970463686 @default.
• W1878991695 cites W1973541879 @default.
• W1878991695 cites W1974096487 @default.
• W1878991695 cites W1974457163 @default.
• W1878991695 cites W1974545869 @default.
• W1878991695 cites W1975690196 @default.
• W1878991695 cites W1978103379 @default.
• W1878991695 cites W1978576762 @default.
• W1878991695 cites W1979364075 @default.
• W1878991695 cites W1980143100 @default.
• W1878991695 cites W1980731038 @default.
• W1878991695 cites W1983427343 @default.
• W1878991695 cites W1984834472 @default.
• W1878991695 cites W1986037443 @default.
• W1878991695 cites W1986827858 @default.
• W1878991695 cites W1988848155 @default.
• W1878991695 cites W1991687557 @default.
• W1878991695 cites W1993965822 @default.
• W1878991695 cites W1994310131 @default.
• W1878991695 cites W1994420770 @default.
• W1878991695 cites W1996006149 @default.
• W1878991695 cites W1996389186 @default.
• W1878991695 cites W1997471955 @default.
• W1878991695 cites W1999777294 @default.
• W1878991695 cites W1999866013 @default.
• W1878991695 cites W2001220220 @default.
• W1878991695 cites W2003892414 @default.
• W1878991695 cites W2005813970 @default.
• W1878991695 cites W2006549880 @default.
• W1878991695 cites W2006566716 @default.
• W1878991695 cites W2006831045 @default.
• W1878991695 cites W2008377881 @default.
• W1878991695 cites W2009343967 @default.
• W1878991695 cites W2010461628 @default.
• W1878991695 cites W2011224376 @default.
• W1878991695 cites W2012756131 @default.
• W1878991695 cites W2013620154 @default.
• W1878991695 cites W2015228675 @default.
• W1878991695 cites W2015475019 @default.
• W1878991695 cites W2018987167 @default.
• W1878991695 cites W2020927386 @default.
• W1878991695 cites W2021821328 @default.
• W1878991695 cites W2023280567 @default.
• W1878991695 cites W2023734944 @default.
• W1878991695 cites W2024085618 @default.
• W1878991695 cites W2024644107 @default.
• W1878991695 cites W2026080578 @default.
• W1878991695 cites W2027049305 @default.
• W1878991695 cites W2028200430 @default.
• W1878991695 cites W2030728818 @default.
• W1878991695 cites W2032140498 @default.
• W1878991695 cites W2033410839 @default.
• W1878991695 cites W2034100892 @default.
• W1878991695 cites W2034976876 @default.
• W1878991695 cites W2040017420 @default.
• W1878991695 cites W2040390440 @default.
• W1878991695 cites W2046188285 @default.
• W1878991695 cites W2046628605 @default.
• W1878991695 cites W2046756698 @default.
• W1878991695 cites W2052095920 @default.
• W1878991695 cites W2053620243 @default.
• W1878991695 cites W2054233490 @default.
• W1878991695 cites W2055277978 @default.
• W1878991695 cites W2055928479 @default.
• W1878991695 cites W2060943696 @default.
• W1878991695 cites W2061200064 @default.
• W1878991695 cites W2062697678 @default.
• W1878991695 cites W2064830115 @default.
• W1878991695 cites W2065501665 @default.
• W1878991695 cites W2067023189 @default.
• W1878991695 cites W2067545345 @default.
• W1878991695 cites W2067595465 @default.
• W1878991695 cites W2067808278 @default.
• W1878991695 cites W2067922683 @default.
• W1878991695 cites W2076357723 @default.
• W1878991695 cites W2077158310 @default.
• W1878991695 cites W2077965112 @default.
• W1878991695 cites W2078624814 @default.

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