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• W1879179565 abstract "287 Objectives A pilot study was performed in 10 patients using 89Zr-labeled J591, an anti PSMA antibody. Serial PET/CT imaging to evaluate biodistribution, kinetics, radiation dosimetry and lesion detectability. Methods Ten patients received 5 mCi/ 2mg of 89Zr J591 with 23 mg of unlabeled antibody. Four whole body PET/CT scans, serial serum samples and whole body counts were obtained. Data were analyzed for normal tissue uptake distribution, lesion targeting, serum and whole body clearance rates and radiation absorbed dose estimates. Results Both skeletal and soft tissue disease was targeted, with a total of 198 lesions detected in 10 patients by 89Zr J591. Mean biological half lives for bi-exponential serum clearance were 7 ± 4.5h (12.3 %/L) and 62 ±13h (17.8 %/L); mean biological half-life for mono-exponential whole body clearance was 219 ± 48h. Mean residence times in whole body, liver and kidney were 79, 26 and 2.0 hr respectively with absorbed dose estimates of 7.7 ± 1.5, 3.5 ± 0.4 and 1.2 ± 0.2 cGy/mCi to liver, kidney and red marrow respectively. Eight of 10 patients had biopsies on a total of 12 lesions of which 11 were 89ZrJ591 positive. All 89ZrJ591 positive lesions were histologically confirmed as prostate cancer. Two 89ZrJ591 positive sites were biopsy-confirmed occult disease. In two patients, nodal disease was identified by 89ZrJ591scans only whereas other imaging (FDG and CT) was negative. Optimal time for imaging based on tumor to background ratios was 7 ± 1 days. Conclusions 89ZrJ591 PET/CT imaging shows excellent targeting of protate cancer lesions. A larger trial is planned to confirm these findings. Research Support Starr consortium grant" @default.
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• W1879179565 date "2013-05-01" @default.
• W1879179565 modified "2023-09-22" @default.
• W1879179565 title "89Zr J591 immunoPET imaging in patients with prostate cancer" @default.
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