FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1879222705> ?p ?o ?g. }

• W1879222705 abstract "Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in breast cancer 1), is frequently amplified and overexpressed in human breast cancer and has been shown to enhance estrogen-dependent transactivation. To better understand the molecular and physiological consequences of AIB1 overexpression in breast cancer cells, an AIB1 cDNA was transfected into the low AIB1 expressing, estrogen-receptor (ER) negative breast cancer cell line, MDA-MB-436. The features of a derivative cell line, designated 436.1, which expresses high levels of AIB1, are described and compared with the parental cell line. A significant increase in the levels of CREB binding protein (CBP) was observed in 436.1 cells and immunofluorescent staining revealed altered AIB1 and CBP staining patterns compared to the parental cells. Further, transient transfection assays demonstrated that the overall estrogen-dependent transactivation in 436.1 cells is approximately 20-fold higher than the parental cells and the estrogen dose-response curve is repositioned to the right. Finally, cDNA microarray analysis of approximately 7,100 cDNAs identified a number of differentially expressed genes in the 436.1 cells. These observations lend insight into downstream signaling pathways that are influenced by AIB1." @default.
• W1879222705 created "2016-06-24" @default.
• W1879222705 creator A5012734710 @default.
• W1879222705 creator A5018945206 @default.
• W1879222705 creator A5023012274 @default.
• W1879222705 creator A5079960913 @default.
• W1879222705 date "2003-09-10" @default.
• W1879222705 modified "2023-09-30" @default.
• W1879222705 title "Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1" @default.
• W1879222705 cites W1613446635 @default.
• W1879222705 cites W1820869110 @default.
• W1879222705 cites W1969070806 @default.
• W1879222705 cites W1974127600 @default.
• W1879222705 cites W19775802 @default.
• W1879222705 cites W1981022538 @default.
• W1879222705 cites W1987341521 @default.
• W1879222705 cites W1990565764 @default.
• W1879222705 cites W1992102887 @default.
• W1879222705 cites W2012155675 @default.
• W1879222705 cites W2021629511 @default.
• W1879222705 cites W2026022568 @default.
• W1879222705 cites W2035856471 @default.
• W1879222705 cites W2039576757 @default.
• W1879222705 cites W2047119203 @default.
• W1879222705 cites W2060128629 @default.
• W1879222705 cites W2061619516 @default.
• W1879222705 cites W2076234060 @default.
• W1879222705 cites W2085124463 @default.
• W1879222705 cites W2089050805 @default.
• W1879222705 cites W2089554403 @default.
• W1879222705 cites W2092986436 @default.
• W1879222705 cites W2094884232 @default.
• W1879222705 cites W2124530000 @default.
• W1879222705 cites W2131103656 @default.
• W1879222705 cites W2131272120 @default.
• W1879222705 cites W2136600170 @default.
• W1879222705 cites W2143241514 @default.
• W1879222705 cites W2144316559 @default.
• W1879222705 cites W2146490125 @default.
• W1879222705 cites W2164285177 @default.
• W1879222705 cites W2167203556 @default.
• W1879222705 cites W2171832365 @default.
• W1879222705 cites W4233622718 @default.
• W1879222705 doi "https://doi.org/10.1186/1471-2407-3-22" @default.
• W1879222705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/201023" @default.
• W1879222705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12964942" @default.
• W1879222705 hasPublicationYear "2003" @default.
• W1879222705 type Work @default.
• W1879222705 sameAs 1879222705 @default.
• W1879222705 citedByCount "12" @default.
• W1879222705 countsByYear W18792227052018 @default.
• W1879222705 countsByYear W18792227052019 @default.
• W1879222705 crossrefType "journal-article" @default.
• W1879222705 hasAuthorship W1879222705A5012734710 @default.
• W1879222705 hasAuthorship W1879222705A5018945206 @default.
• W1879222705 hasAuthorship W1879222705A5023012274 @default.
• W1879222705 hasAuthorship W1879222705A5079960913 @default.
• W1879222705 hasBestOaLocation W18792227051 @default.
• W1879222705 hasConcept C104317684 @default.
• W1879222705 hasConcept C121608353 @default.
• W1879222705 hasConcept C126322002 @default.
• W1879222705 hasConcept C1292079 @default.
• W1879222705 hasConcept C134018914 @default.
• W1879222705 hasConcept C153911025 @default.
• W1879222705 hasConcept C172313692 @default.
• W1879222705 hasConcept C203966977 @default.
• W1879222705 hasConcept C502942594 @default.
• W1879222705 hasConcept C530470458 @default.
• W1879222705 hasConcept C54009773 @default.
• W1879222705 hasConcept C54355233 @default.
• W1879222705 hasConcept C63932345 @default.
• W1879222705 hasConcept C71924100 @default.
• W1879222705 hasConcept C77445288 @default.
• W1879222705 hasConcept C81885089 @default.
• W1879222705 hasConcept C84606932 @default.
• W1879222705 hasConcept C86339819 @default.
• W1879222705 hasConcept C86803240 @default.
• W1879222705 hasConceptScore W1879222705C104317684 @default.
• W1879222705 hasConceptScore W1879222705C121608353 @default.
• W1879222705 hasConceptScore W1879222705C126322002 @default.
• W1879222705 hasConceptScore W1879222705C1292079 @default.
• W1879222705 hasConceptScore W1879222705C134018914 @default.
• W1879222705 hasConceptScore W1879222705C153911025 @default.
• W1879222705 hasConceptScore W1879222705C172313692 @default.
• W1879222705 hasConceptScore W1879222705C203966977 @default.
• W1879222705 hasConceptScore W1879222705C502942594 @default.
• W1879222705 hasConceptScore W1879222705C530470458 @default.
• W1879222705 hasConceptScore W1879222705C54009773 @default.
• W1879222705 hasConceptScore W1879222705C54355233 @default.
• W1879222705 hasConceptScore W1879222705C63932345 @default.
• W1879222705 hasConceptScore W1879222705C71924100 @default.
• W1879222705 hasConceptScore W1879222705C77445288 @default.
• W1879222705 hasConceptScore W1879222705C81885089 @default.
• W1879222705 hasConceptScore W1879222705C84606932 @default.
• W1879222705 hasConceptScore W1879222705C86339819 @default.
• W1879222705 hasConceptScore W1879222705C86803240 @default.
• W1879222705 hasIssue "1" @default.
• W1879222705 hasLocation W18792227051 @default.
• W1879222705 hasLocation W18792227052 @default.
• W1879222705 hasLocation W18792227053 @default.

• next