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- W1879366838 endingPage "1673" @default.
- W1879366838 startingPage "1661" @default.
- W1879366838 abstract "Summary Pyoverdines are siderophores produced by fluorescent P seudomonads to acquire iron. At least 60 different pyoverdines produced by diverse strains have been chemically characterized. They all consist of a dihydroquinoline‐type chromophore linked to a peptide. These peptides are of various lengths and the sequences are strain specific. Pyoverdine biosynthesis in P seudomonas aeruginosa and fluorescent P seudomonads is a complex process involving at least 12 different proteins, starting in the cytoplasm and ending in the periplasm. The cellular localization of pyoverdine precursors was recently shown to be consistent with their biosynthetic enzymes. In the cytoplasm, pyoverdine appears to be assembled at the inner membrane and particularly at the old cell pole of the bacterium. Mature pyoverdine is uniformly distributed throughout the periplasm, like the periplasmic enzyme PvdQ . Secretion of pyoverdine involves a recently identified ATP ‐dependent efflux pump, PvdRT ‐ OpmQ . This efflux system does not only secrete newly synthesized pyoverdine but also pyoverdine that already transported iron into the bacterial periplasm and any pyoverdine–metal complex other than ferri‐pyoverdine present in the periplasm. This review considers how these new insights into pyoverdine biosynthesis and secretion contribute to our understanding of the role of pyoverdine in iron and metal homeostasis in fluorescent P seudomonads." @default.
- W1879366838 created "2016-06-24" @default.
- W1879366838 creator A5053009039 @default.
- W1879366838 creator A5053778909 @default.
- W1879366838 date "2012-11-06" @default.
- W1879366838 modified "2023-10-17" @default.
- W1879366838 title "Pyoverdine biosynthesis and secretion in<i>Pseudomonas aeruginosa</i>: implications for metal homeostasis" @default.
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- W1879366838 doi "https://doi.org/10.1111/1462-2920.12013" @default.
- W1879366838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23126435" @default.
- W1879366838 hasPublicationYear "2012" @default.
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