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- W1879870480 abstract "Abstract An investigation of clavulanic acid behavior in an aqueous two‐phase micellar system employing the surfactants n ‐decyltetraethylene oxide (C 10 E 4 ) and dodecyldimethylamine oxide (DDAO) was carried out. According to the results, clavulanic acid partitions evenly between the two phases of DDAO micellar system, mixed DDAO–C 10 E 4 micellar system, as well as C 10 E 4 micellar system. Therefore, electrostatic interactions between positively charged DDAO‐containing micelles and negatively charged drug were not strong enough to influence the partitioning. Nevertheless, clavulanic acid extraction from Streptomyces clavuligerus fermentation broth in C 10 E 4 micellar system employing a previous protein denaturation step provided recovery of 52% clavulanic acid with removal of 70% of the contaminant proteins, which is already promising as a purification strategy." @default.
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- W1879870480 date "2011-03-01" @default.
- W1879870480 modified "2023-10-17" @default.
- W1879870480 title "Extraction of clavulanic acid using aqueous two-phase micellar system" @default.
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- W1879870480 doi "https://doi.org/10.1002/bab.20" @default.
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