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- W1879996294 abstract "Macroprolactin is a complex of prolactin with immunoglobulin (IgG) that in vivo appears to have limited or no biological activity, possibly because of the failure of the high-molecular weight complex to cross capillary walls (1). The predominant form of prolactin in serum in the general population is monomeric prolactin, but the prevalence of macroprolactin in serum is not known. However, when samples with increased prolactin are further investigated, it has been reported that up to 26% of these samples contain macroprolactin as the predominant form (2)(3). Immunoassays for prolactin have variable reactivity with macroprolactin; therefore, its presence should be considered in the differential diagnosis of hyperprolactinemia. This clinical problem is illustrated by the following two patients who were referred, from the same local hospital, to our endocrine center for the investigation of hyperprolactinemia.### Clinical case 1.A 38-year-old female volunteer in a clinical trial had serum prolactin concentrations of 1168–1748 mIU/L (reference interval <420 mIU/L) on three occasions at her …" @default.
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- W1879996294 date "2000-06-01" @default.
- W1879996294 modified "2023-10-05" @default.
- W1879996294 title "Macroprolactin Reactivities in Prolactin Assays: An Issue for Clinical Laboratories and Equipment Manufacturers" @default.
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- W1879996294 doi "https://doi.org/10.1093/clinchem/46.6.884" @default.
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