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• W1880007343 abstract "In this chapter, an attempt is made to describe the principal pharmacologic and therapeutic effects of the benzodiazepines and to correlate the experimental findings in animals with clinical observations in normal human subjects and patients with a variety of psychoneurotic, mental, and neurological disorders. Based on experience with chlordiazepoxide and diazepam, the first benzodiazepines introduced in clinical practice and the still limited observations with a number of newer analogs, it is shown that therapeutic efficacy and side effect liability can, in part, be directly related to the pharmacologic effects in normal animals or especially prepared animal models. For other clinical observations, however, the pharmacologic basis remains speculative. The comparison with other psychotropic agents provides further data that may shed some light on the significance of animal testing for the predication of the therapeutic value of psychotropic drugs. The chapter represents an attempt to correlate on a broad basis the knowledge obtained in animal experiments with the clinical experience in human. It is clear that in the atmosphere of exploration and discovery that is always created by a new class of drugs, clinicians, and basic scientists usually tend to pursue their respective research goals without too much concern about the results of other disciplines. Drug effects on conditioned animal behavior, for example, are one of the areas where basic scientists have gained an enormous amount of data, but have not been able to correlate many of these results with clinically observed drug actions in human. The new and interesting findings on the maintenance of muscle tone through the interplay of the alpha and gamma motor neurons have greatly advanced the knowledge of motor reflexes and experimental induction of the spasticity of isolated muscles in cats." @default.
• W1880007343 created "2016-06-24" @default.
• W1880007343 creator A5031784156 @default.
• W1880007343 creator A5037949900 @default.
• W1880007343 date "1967-01-01" @default.
• W1880007343 modified "2023-09-26" @default.
• W1880007343 title "Pharmacology of Benzodiazepines: Laboratory and Clinical Correlations" @default.
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