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• W1880253657 endingPage "403" @default.
• W1880253657 startingPage "391" @default.
• W1880253657 abstract "Aim: Reduced muscle force greater than expected from loss of muscle mass has been reported in ageing muscles. Impaired sarcoplasmic reticulum (SR) Ca2+ release has been implicated as a possible mechanism, and attributed to several factors, including loss of ryanodine receptor (RYR) expression and protein binding. The aim of this study was to evaluate muscle quality and SR Ca2+ release in ageing rats that were not so old that major atrophy had occurred. Methods: We collected in situ force data from the plantarflexor muscle group and muscle mass from the constituent muscles to determine muscle quality (force/mass) in adult (6–8 months) and ageing (24 months) rats (n = 8/group). We evaluated SR Ca2+ uptake and release, and determined expression of key proteins associated with Ca2+ release [RYR and FK506 binding protein (FKBP)] and uptake (SERCA, parvalbumin, calsequestrin). Results: Plantarflexor force and muscle quality were reduced with ageing (approx. 28 and 34%, respectively), but atrophy was limited, and significant only in the medial gastrocnemius (approx. 15%). The fast phase of SR Ca2+ release was reduced with ageing in both gastrocnemii, as was FKBP expression and FKBP–RYR binding, but RYR expression was not affected. Similar, but non-significant changes were present in the plantaris, but the soleus muscle generally showed no ageing-related changes. Conclusion: These data suggest a possible role for impaired SR Ca2+ release in ageing-related loss of muscle quality, although not through loss of RYR expression." @default.
• W1880253657 created "2016-06-24" @default.
• W1880253657 creator A5041736581 @default.
• W1880253657 creator A5043836788 @default.
• W1880253657 creator A5049268537 @default.
• W1880253657 creator A5074474221 @default.
• W1880253657 date "2010-11-09" @default.
• W1880253657 modified "2023-09-25" @default.
• W1880253657 title "Ageing, but not yet senescent, rats exhibit reduced muscle quality and sarcoplasmic reticulum function" @default.
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• W1880253657 doi "https://doi.org/10.1111/j.1748-1716.2010.02191.x" @default.
• W1880253657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20874807" @default.
• W1880253657 hasPublicationYear "2010" @default.
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