Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880323912> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1880323912 endingPage "31S" @default.
- W1880323912 startingPage "19S" @default.
- W1880323912 abstract "Lynch syndrome is the most common hereditary form of colorectal cancer (CRC). Its natural history has been investigated extensively, so that highly targeted surveillance and management strategies, melded to its natural history, have proven effective in cancer control. Most important is the early age of onset of cancer (approximately 44 years), involving CRC and the several extracolonic cancers that are integral to the syndrome. With respect to CRC, approximately 70% of cases occur proximal to the splenic flexure. Synchronous and metachronous CRCs are extremely common. Full colonoscopy should be initiated when the patient is between the ages of 20 and 25, and because of the accelerated carcinogenesis of CRC, it should be performed every 1 to 2 years. The presence of initial CRC requires subtotal colectomy, given the mentioned increased frequency of metachronous cancer. Options available for germ-line mutation carriers, in addition to cancer screening, include prophylactic colectomy as well as prophylactic total abdominal hysterectomy and bilateral salpingo-oophorectomy. The discovery of mismatch repair germ-line mutations (most commonly MSH2 or MLH1) has added significantly to the recognition of this disease as well as to the search for high-risk individuals throughout families who, with genetic counseling, may become candidates for germ-line mutation testing. Clearly, hereditary nonpolyposis colorectal cancer provides an excellent opportunity for learning about the etio-pathogenesis of cancer at the molecular and clinical levels and how this knowledge might ultimately be exploited for cancer control. A search for chemoprevention agents, such as cyclo-oxygenase 2 inhibitors, as well as for putative environmental effects and how they may interact with the genetic component in CRC etiology should abet this entire cancer control process." @default.
- W1880323912 created "2016-06-24" @default.
- W1880323912 creator A5029960276 @default.
- W1880323912 creator A5084172703 @default.
- W1880323912 date "2000-11-01" @default.
- W1880323912 modified "2023-09-23" @default.
- W1880323912 title "Lynch syndrome: genetics, natural history, genetic counseling, and prevention." @default.
- W1880323912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11060321" @default.
- W1880323912 hasPublicationYear "2000" @default.
- W1880323912 type Work @default.
- W1880323912 sameAs 1880323912 @default.
- W1880323912 citedByCount "34" @default.
- W1880323912 countsByYear W18803239122012 @default.
- W1880323912 countsByYear W18803239122015 @default.
- W1880323912 countsByYear W18803239122016 @default.
- W1880323912 countsByYear W18803239122017 @default.
- W1880323912 countsByYear W18803239122018 @default.
- W1880323912 countsByYear W18803239122019 @default.
- W1880323912 countsByYear W18803239122021 @default.
- W1880323912 countsByYear W18803239122022 @default.
- W1880323912 crossrefType "journal-article" @default.
- W1880323912 hasAuthorship W1880323912A5029960276 @default.
- W1880323912 hasAuthorship W1880323912A5084172703 @default.
- W1880323912 hasConcept C111425858 @default.
- W1880323912 hasConcept C121608353 @default.
- W1880323912 hasConcept C126322002 @default.
- W1880323912 hasConcept C143998085 @default.
- W1880323912 hasConcept C163276114 @default.
- W1880323912 hasConcept C2776559941 @default.
- W1880323912 hasConcept C2776674815 @default.
- W1880323912 hasConcept C2778435480 @default.
- W1880323912 hasConcept C2779115348 @default.
- W1880323912 hasConcept C2780234812 @default.
- W1880323912 hasConcept C2780673598 @default.
- W1880323912 hasConcept C2780814781 @default.
- W1880323912 hasConcept C2781179581 @default.
- W1880323912 hasConcept C526805850 @default.
- W1880323912 hasConcept C54355233 @default.
- W1880323912 hasConcept C60748783 @default.
- W1880323912 hasConcept C71924100 @default.
- W1880323912 hasConcept C80227256 @default.
- W1880323912 hasConcept C86803240 @default.
- W1880323912 hasConceptScore W1880323912C111425858 @default.
- W1880323912 hasConceptScore W1880323912C121608353 @default.
- W1880323912 hasConceptScore W1880323912C126322002 @default.
- W1880323912 hasConceptScore W1880323912C143998085 @default.
- W1880323912 hasConceptScore W1880323912C163276114 @default.
- W1880323912 hasConceptScore W1880323912C2776559941 @default.
- W1880323912 hasConceptScore W1880323912C2776674815 @default.
- W1880323912 hasConceptScore W1880323912C2778435480 @default.
- W1880323912 hasConceptScore W1880323912C2779115348 @default.
- W1880323912 hasConceptScore W1880323912C2780234812 @default.
- W1880323912 hasConceptScore W1880323912C2780673598 @default.
- W1880323912 hasConceptScore W1880323912C2780814781 @default.
- W1880323912 hasConceptScore W1880323912C2781179581 @default.
- W1880323912 hasConceptScore W1880323912C526805850 @default.
- W1880323912 hasConceptScore W1880323912C54355233 @default.
- W1880323912 hasConceptScore W1880323912C60748783 @default.
- W1880323912 hasConceptScore W1880323912C71924100 @default.
- W1880323912 hasConceptScore W1880323912C80227256 @default.
- W1880323912 hasConceptScore W1880323912C86803240 @default.
- W1880323912 hasIssue "21 Suppl" @default.
- W1880323912 hasLocation W18803239121 @default.
- W1880323912 hasOpenAccess W1880323912 @default.
- W1880323912 hasPrimaryLocation W18803239121 @default.
- W1880323912 hasRelatedWork W1446253238 @default.
- W1880323912 hasRelatedWork W1509212822 @default.
- W1880323912 hasRelatedWork W1880323912 @default.
- W1880323912 hasRelatedWork W2015035823 @default.
- W1880323912 hasRelatedWork W2092950859 @default.
- W1880323912 hasRelatedWork W2142136137 @default.
- W1880323912 hasRelatedWork W2559494189 @default.
- W1880323912 hasRelatedWork W2589313363 @default.
- W1880323912 hasRelatedWork W4224056320 @default.
- W1880323912 hasRelatedWork W70233215 @default.
- W1880323912 hasVolume "18" @default.
- W1880323912 isParatext "false" @default.
- W1880323912 isRetracted "false" @default.
- W1880323912 magId "1880323912" @default.
- W1880323912 workType "article" @default.