FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880343695> ?p ?o ?g. }

• W1880343695 endingPage "343" @default.
• W1880343695 startingPage "334" @default.
• W1880343695 abstract "Medulloblastoma (MB) is composed of four molecular subgroups viz. WNT, SHH, groups 3 and 4, identified using various high-throughput methods. Translation of this molecular data into pathologist-friendly techniques that would be applicable in laboratories all over the world is a major challenge. Ninety-two MBs were analyzed using a panel of 10 IHC markers, real-time PCR for mRNA and miRNA expression, and FISH for MYC amplification. β-catenin, GAB1 and YAP1 were the only IHC markers of utility in classification of MBs into three subgroups viz. WNT (9.8%), SHH (45.6%) and non-WNT/SHH (44.6%). mRNA expression could further classify some non-WNT/SHH tumors into groups 3 and 4. This, however, was dependent on integrity of RNA extracted from FFPE tissue. MYC amplification was seen in 20% of non-WNT/SHH cases and was associated with the worst prognosis. For routine diagnostic practice, we recommend classification of MBs into three subgroups: WNT, SHH and non-WNT/SHH, with supplementation by prognostic markers like MYC for non-WNT/SHH tumors. Using this panel, we propose a new three-tier risk stratification system for MBs. Molecular subgrouping with this limited panel is rapid, economical, works well on FFPE tissue and is reliable as it correlates significantly with clinicopathological parameters and patient survival." @default.
• W1880343695 created "2016-06-24" @default.
• W1880343695 creator A5015911393 @default.
• W1880343695 creator A5016258591 @default.
• W1880343695 creator A5024515956 @default.
• W1880343695 creator A5031247280 @default.
• W1880343695 creator A5034670982 @default.
• W1880343695 creator A5039006628 @default.
• W1880343695 creator A5064979397 @default.
• W1880343695 creator A5073462477 @default.
• W1880343695 creator A5074008112 @default.
• W1880343695 creator A5084725442 @default.
• W1880343695 date "2015-09-09" @default.
• W1880343695 modified "2023-10-15" @default.
• W1880343695 title "Integrating Molecular Subclassification of Medulloblastomas into Routine Clinical Practice: A Simplified Approach" @default.
• W1880343695 cites W1530069278 @default.
• W1880343695 cites W1995541594 @default.
• W1880343695 cites W1996409634 @default.
• W1880343695 cites W2004456850 @default.
• W1880343695 cites W2045711626 @default.
• W1880343695 cites W2051976171 @default.
• W1880343695 cites W2070264387 @default.
• W1880343695 cites W2071064669 @default.
• W1880343695 cites W2089635935 @default.
• W1880343695 cites W2099920119 @default.
• W1880343695 cites W2110529088 @default.
• W1880343695 cites W2111130338 @default.
• W1880343695 cites W2112688027 @default.
• W1880343695 cites W2118097751 @default.
• W1880343695 cites W2118124054 @default.
• W1880343695 cites W2120452752 @default.
• W1880343695 cites W2125567892 @default.
• W1880343695 cites W2127643721 @default.
• W1880343695 cites W2129331946 @default.
• W1880343695 cites W2139787372 @default.
• W1880343695 cites W2140266186 @default.
• W1880343695 cites W2146729334 @default.
• W1880343695 cites W2151034811 @default.
• W1880343695 cites W2151113527 @default.
• W1880343695 cites W2151745496 @default.
• W1880343695 cites W2153398041 @default.
• W1880343695 cites W2154951934 @default.
• W1880343695 cites W2171473481 @default.
• W1880343695 cites W2337433062 @default.
• W1880343695 cites W23556053 @default.
• W1880343695 doi "https://doi.org/10.1111/bpa.12293" @default.
• W1880343695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8029101" @default.
• W1880343695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26222673" @default.
• W1880343695 hasPublicationYear "2015" @default.
• W1880343695 type Work @default.
• W1880343695 sameAs 1880343695 @default.
• W1880343695 citedByCount "50" @default.
• W1880343695 countsByYear W18803436952015 @default.
• W1880343695 countsByYear W18803436952016 @default.
• W1880343695 countsByYear W18803436952017 @default.
• W1880343695 countsByYear W18803436952018 @default.
• W1880343695 countsByYear W18803436952019 @default.
• W1880343695 countsByYear W18803436952020 @default.
• W1880343695 countsByYear W18803436952021 @default.
• W1880343695 countsByYear W18803436952022 @default.
• W1880343695 countsByYear W18803436952023 @default.
• W1880343695 crossrefType "journal-article" @default.
• W1880343695 hasAuthorship W1880343695A5015911393 @default.
• W1880343695 hasAuthorship W1880343695A5016258591 @default.
• W1880343695 hasAuthorship W1880343695A5024515956 @default.
• W1880343695 hasAuthorship W1880343695A5031247280 @default.
• W1880343695 hasAuthorship W1880343695A5034670982 @default.
• W1880343695 hasAuthorship W1880343695A5039006628 @default.
• W1880343695 hasAuthorship W1880343695A5064979397 @default.
• W1880343695 hasAuthorship W1880343695A5073462477 @default.
• W1880343695 hasAuthorship W1880343695A5074008112 @default.
• W1880343695 hasAuthorship W1880343695A5084725442 @default.
• W1880343695 hasBestOaLocation W18803436952 @default.
• W1880343695 hasConcept C142724271 @default.
• W1880343695 hasConcept C19527891 @default.
• W1880343695 hasConcept C2779974597 @default.
• W1880343695 hasConcept C2780789225 @default.
• W1880343695 hasConcept C41008148 @default.
• W1880343695 hasConcept C512399662 @default.
• W1880343695 hasConcept C71924100 @default.
• W1880343695 hasConceptScore W1880343695C142724271 @default.
• W1880343695 hasConceptScore W1880343695C19527891 @default.
• W1880343695 hasConceptScore W1880343695C2779974597 @default.
• W1880343695 hasConceptScore W1880343695C2780789225 @default.
• W1880343695 hasConceptScore W1880343695C41008148 @default.
• W1880343695 hasConceptScore W1880343695C512399662 @default.
• W1880343695 hasConceptScore W1880343695C71924100 @default.
• W1880343695 hasIssue "3" @default.
• W1880343695 hasLocation W18803436951 @default.
• W1880343695 hasLocation W18803436952 @default.
• W1880343695 hasOpenAccess W1880343695 @default.
• W1880343695 hasPrimaryLocation W18803436951 @default.
• W1880343695 hasRelatedWork W1277124008 @default.
• W1880343695 hasRelatedWork W2018300183 @default.
• W1880343695 hasRelatedWork W2355847449 @default.
• W1880343695 hasRelatedWork W2385506543 @default.
• W1880343695 hasRelatedWork W2748952813 @default.
• W1880343695 hasRelatedWork W2783129026 @default.

• next