Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880452519> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1880452519 endingPage "5338" @default.
- W1880452519 startingPage "5331" @default.
- W1880452519 abstract "We studied the repair of UV- and aflatoxin B1 (AFB1)-induced damage in the human metallothionein (hMT) gene family. After exposure to either UV or AFB1, DNA damage was initially repaired faster in the DNA fragments containing the transcribed hMT-IA, hMT-IE, and hMT-IIA genes than in the genome overall. By 6 h posttreatment, there was at least twice as much repair in these genes as in the rest of the genome. Repair of UV damage in the hMT-IB gene, which shows cell-type specific expression, and in the hMT-IIB gene, which is a nontranscribed processed pseudogene, was about the same as in the rest of the genome, whereas repair of AFB1-induced damage was deficient in these two genes. Inducing transcription of the three expressed hMT genes with CdCl2 or of only the hMT-IIA gene with dexamethasone increased the initial rate of repair in the induced genes another twofold over the rate observed when they were transcribed at a basal level. The rates of repair in the hMT-IB and hMT-IIB genes were not altered by these inducing treatments. Transcription of the hMT genes was transiently inhibited after UV irradiation. Inducing transcription of the genes did not shorten this UV-induced delay. Thus, the efficiency of repair of damage in a DNA sequence is dependent on the level of transcriptional activity associated with that sequence. However, an increased efficiency in repair of a gene itself is not necessarily coupled to recovery of its transcription after DNA damage." @default.
- W1880452519 created "2016-06-24" @default.
- W1880452519 creator A5066104958 @default.
- W1880452519 creator A5086232273 @default.
- W1880452519 date "1988-12-01" @default.
- W1880452519 modified "2023-09-26" @default.
- W1880452519 title "Differential repair of DNA damage in the human metallothionein gene family." @default.
- W1880452519 cites W113309747 @default.
- W1880452519 cites W1517936321 @default.
- W1880452519 cites W1524941871 @default.
- W1880452519 cites W1643353036 @default.
- W1880452519 cites W1867843855 @default.
- W1880452519 cites W1875766822 @default.
- W1880452519 cites W1970863559 @default.
- W1880452519 cites W1975508610 @default.
- W1880452519 cites W1980299957 @default.
- W1880452519 cites W1981900473 @default.
- W1880452519 cites W1984353960 @default.
- W1880452519 cites W1987035682 @default.
- W1880452519 cites W1987364221 @default.
- W1880452519 cites W1988432717 @default.
- W1880452519 cites W1988892151 @default.
- W1880452519 cites W1993359545 @default.
- W1880452519 cites W1998704801 @default.
- W1880452519 cites W2011603566 @default.
- W1880452519 cites W2041296252 @default.
- W1880452519 cites W2042237201 @default.
- W1880452519 cites W2042560825 @default.
- W1880452519 cites W2044633350 @default.
- W1880452519 cites W2055296329 @default.
- W1880452519 cites W2059901912 @default.
- W1880452519 cites W2063450941 @default.
- W1880452519 cites W2067234441 @default.
- W1880452519 cites W2085064863 @default.
- W1880452519 cites W2086955288 @default.
- W1880452519 cites W2093458878 @default.
- W1880452519 cites W2095335043 @default.
- W1880452519 cites W2144634347 @default.
- W1880452519 cites W2162954010 @default.
- W1880452519 cites W90138503 @default.
- W1880452519 doi "https://doi.org/10.1128/mcb.8.12.5331" @default.
- W1880452519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/365635" @default.
- W1880452519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3149714" @default.
- W1880452519 hasPublicationYear "1988" @default.
- W1880452519 type Work @default.
- W1880452519 sameAs 1880452519 @default.
- W1880452519 citedByCount "56" @default.
- W1880452519 countsByYear W18804525192016 @default.
- W1880452519 crossrefType "journal-article" @default.
- W1880452519 hasAuthorship W1880452519A5066104958 @default.
- W1880452519 hasAuthorship W1880452519A5086232273 @default.
- W1880452519 hasBestOaLocation W18804525192 @default.
- W1880452519 hasConcept C104317684 @default.
- W1880452519 hasConcept C134935766 @default.
- W1880452519 hasConcept C138885662 @default.
- W1880452519 hasConcept C141231307 @default.
- W1880452519 hasConcept C143425029 @default.
- W1880452519 hasConcept C153911025 @default.
- W1880452519 hasConcept C179926584 @default.
- W1880452519 hasConcept C34957205 @default.
- W1880452519 hasConcept C41895202 @default.
- W1880452519 hasConcept C54355233 @default.
- W1880452519 hasConcept C552990157 @default.
- W1880452519 hasConcept C86803240 @default.
- W1880452519 hasConceptScore W1880452519C104317684 @default.
- W1880452519 hasConceptScore W1880452519C134935766 @default.
- W1880452519 hasConceptScore W1880452519C138885662 @default.
- W1880452519 hasConceptScore W1880452519C141231307 @default.
- W1880452519 hasConceptScore W1880452519C143425029 @default.
- W1880452519 hasConceptScore W1880452519C153911025 @default.
- W1880452519 hasConceptScore W1880452519C179926584 @default.
- W1880452519 hasConceptScore W1880452519C34957205 @default.
- W1880452519 hasConceptScore W1880452519C41895202 @default.
- W1880452519 hasConceptScore W1880452519C54355233 @default.
- W1880452519 hasConceptScore W1880452519C552990157 @default.
- W1880452519 hasConceptScore W1880452519C86803240 @default.
- W1880452519 hasIssue "12" @default.
- W1880452519 hasLocation W18804525191 @default.
- W1880452519 hasLocation W18804525192 @default.
- W1880452519 hasLocation W18804525193 @default.
- W1880452519 hasOpenAccess W1880452519 @default.
- W1880452519 hasPrimaryLocation W18804525191 @default.
- W1880452519 hasRelatedWork W1565897669 @default.
- W1880452519 hasRelatedWork W1880452519 @default.
- W1880452519 hasRelatedWork W1981393315 @default.
- W1880452519 hasRelatedWork W2007559212 @default.
- W1880452519 hasRelatedWork W2018135334 @default.
- W1880452519 hasRelatedWork W2029633625 @default.
- W1880452519 hasRelatedWork W2069184423 @default.
- W1880452519 hasRelatedWork W2518774397 @default.
- W1880452519 hasRelatedWork W4237098121 @default.
- W1880452519 hasRelatedWork W2187207551 @default.
- W1880452519 hasVolume "8" @default.
- W1880452519 isParatext "false" @default.
- W1880452519 isRetracted "false" @default.
- W1880452519 magId "1880452519" @default.
- W1880452519 workType "article" @default.