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- W1880471187 abstract "Pulmonary hypertension (PH) is a common complication of advanced chronic obstructive pulmonary disease (COPD) and its presence is associated with decreased survival. Owing to its frequency, COPD is by far the most common cause of PH. PH is consecutive to the elevation of pulmonary vascular resistance which is due to functional and morphological factors (chronic alveolar hypoxia is the most important). PH is generally mild to moderate, with mean pulmonary artery pressure (PAP) usually ranging between 20 and 35 mm Hg at rest in a stable state of the disease. A small proportion of COPD patients may present a severe or ‘disproportionate’ PH with a resting PAP > 35–40 mm Hg. The prognosis is poor in these patients; PH usually worsens during exercise, sleep, and severe exacerbations of the disease. These acute increases in after load may favor the development of right heart failure. The diagnosis of PH relies on Doppler echocardiography, and right heart catheterization is needed in a minority of patients. Treatment of PH in COPD relies on long-term oxygen therapy (≧16 h/day), which generally stabilizes, or at east attenuates, and sometimes reverses the progression of PH. ‘New’ vasodilator drugs have rarely been used in COPD. Patients with severe PH should be referred to a specialist PH center where the possibility of inclusion in controlled clinical trials should be considered." @default.
- W1880471187 created "2016-06-24" @default.
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- W1880471187 date "2012-01-01" @default.
- W1880471187 modified "2023-09-25" @default.
- W1880471187 title "Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease" @default.
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- W1880471187 doi "https://doi.org/10.1159/000334365" @default.
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