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- W1880495637 endingPage "15418" @default.
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- W1880495637 abstract "The aza-Michael addition reaction is a vital transformation for the synthesis of functionalized chiral amines. Despite intensive research, enantioselective aza-Michael reactions with alkyl amines as the nitrogen donor have not been successful. We report the use of chiral N-heterocyclic carbenes (NHCs) as noncovalent organocatalysts to promote a highly selective aza-Michael reaction between primary alkyl amines and β-trifluoromethyl β-aryl nitroolefins. In contrast to classical conjugate-addition reactions, a strategy of HOMO-raising activation was used. Chiral trifluoromethylated amines were synthesized in high yield (up to 99 %) with excellent enantioselectivity (up to 98 % ee)." @default.
- W1880495637 created "2016-06-24" @default.
- W1880495637 creator A5000288536 @default.
- W1880495637 creator A5053699255 @default.
- W1880495637 creator A5065502904 @default.
- W1880495637 date "2015-10-30" @default.
- W1880495637 modified "2023-10-18" @default.
- W1880495637 title "Highly Enantioselective Aza‐Michael Reaction between Alkyl Amines and β‐Trifluoromethyl β‐Aryl Nitroolefins" @default.
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- W1880495637 doi "https://doi.org/10.1002/anie.201508371" @default.
- W1880495637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26516707" @default.
- W1880495637 hasPublicationYear "2015" @default.
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