FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880510516> ?p ?o ?g. }

• W1880510516 endingPage "43" @default.
• W1880510516 startingPage "235" @default.
• W1880510516 abstract "The c-raf-1 protooncogene encodes a p72-74 serine/threonine-specific kinase that has been implicated in growth factor-mediated signal transduction and malignant transformation. Here, we compared the effects of Ha-c-ras and v-src oncogenes on the regulation of p72-74 RAF-1 kinase in NIH3T3 cells. In both serum-starved and platelet-derived growth factor-treated v-src-transformed cells, the RAF-1 kinase was constitutively activated, displaying characteristic retarded mobility in electrophoretic gels and elevated activity in in vitro kinase assays. In contrast, the RAF-1 protein from quiescent ras-transformed cells did not exhibit constitutively shifted gel mobility or elevated kinase activity but did respond normally with regard to platelet-derived growth factor- and phorbol myristate acetate-induced changes in p72-74 RAF-1 phosphorylation and kinase activity. 3T3 cells transformed by ras, however, contained elevated levels of p72-74 RAF-1 protein (as determined by immunoblotting), suggesting an indirect influence on this kinase. Quantitative differences in the levels and subcellular distribution of immunodetectable protein kinase C enzymes did not account for the differences between src- and ras-transformed 3T3 cells with regard to regulation of the RAF kinase. These findings in serum-deprived 3T3 cells demonstrate that expression of a ras oncogene can be insufficient for full activation of the p72-74 RAF-1 kinase, implying necessity for an additional growth factor-mediated stimulus." @default.
• W1880510516 created "2016-06-24" @default.
• W1880510516 creator A5001270756 @default.
• W1880510516 creator A5006566731 @default.
• W1880510516 creator A5026156382 @default.
• W1880510516 creator A5059438505 @default.
• W1880510516 creator A5073190868 @default.
• W1880510516 date "1991-05-01" @default.
• W1880510516 modified "2023-09-23" @default.
• W1880510516 title "Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes." @default.
• W1880510516 cites W1486808382 @default.
• W1880510516 cites W1505684107 @default.
• W1880510516 cites W1506671658 @default.
• W1880510516 cites W1547224370 @default.
• W1880510516 cites W1557235975 @default.
• W1880510516 cites W1574212876 @default.
• W1880510516 cites W1873254229 @default.
• W1880510516 cites W1964839077 @default.
• W1880510516 cites W1980201126 @default.
• W1880510516 cites W1983501834 @default.
• W1880510516 cites W1987757198 @default.
• W1880510516 cites W2023023900 @default.
• W1880510516 cites W2032923234 @default.
• W1880510516 cites W2062039330 @default.
• W1880510516 cites W2075918262 @default.
• W1880510516 cites W2084565769 @default.
• W1880510516 cites W2088059732 @default.
• W1880510516 cites W2093583770 @default.
• W1880510516 cites W2096835804 @default.
• W1880510516 cites W2101108802 @default.
• W1880510516 cites W2104658211 @default.
• W1880510516 cites W2121400349 @default.
• W1880510516 cites W2468851658 @default.
• W1880510516 cites W2468882383 @default.
• W1880510516 cites W80640741 @default.
• W1880510516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1888699" @default.
• W1880510516 hasPublicationYear "1991" @default.
• W1880510516 type Work @default.
• W1880510516 sameAs 1880510516 @default.
• W1880510516 citedByCount "15" @default.
• W1880510516 crossrefType "journal-article" @default.
• W1880510516 hasAuthorship W1880510516A5001270756 @default.
• W1880510516 hasAuthorship W1880510516A5006566731 @default.
• W1880510516 hasAuthorship W1880510516A5026156382 @default.
• W1880510516 hasAuthorship W1880510516A5059438505 @default.
• W1880510516 hasAuthorship W1880510516A5073190868 @default.
• W1880510516 hasConcept C104317684 @default.
• W1880510516 hasConcept C108636557 @default.
• W1880510516 hasConcept C124160383 @default.
• W1880510516 hasConcept C153911025 @default.
• W1880510516 hasConcept C159479382 @default.
• W1880510516 hasConcept C184235292 @default.
• W1880510516 hasConcept C195794163 @default.
• W1880510516 hasConcept C2776746612 @default.
• W1880510516 hasConcept C51853150 @default.
• W1880510516 hasConcept C54009773 @default.
• W1880510516 hasConcept C55493867 @default.
• W1880510516 hasConcept C59143045 @default.
• W1880510516 hasConcept C82495950 @default.
• W1880510516 hasConcept C86803240 @default.
• W1880510516 hasConcept C90934575 @default.
• W1880510516 hasConcept C95444343 @default.
• W1880510516 hasConcept C97029542 @default.
• W1880510516 hasConceptScore W1880510516C104317684 @default.
• W1880510516 hasConceptScore W1880510516C108636557 @default.
• W1880510516 hasConceptScore W1880510516C124160383 @default.
• W1880510516 hasConceptScore W1880510516C153911025 @default.
• W1880510516 hasConceptScore W1880510516C159479382 @default.
• W1880510516 hasConceptScore W1880510516C184235292 @default.
• W1880510516 hasConceptScore W1880510516C195794163 @default.
• W1880510516 hasConceptScore W1880510516C2776746612 @default.
• W1880510516 hasConceptScore W1880510516C51853150 @default.
• W1880510516 hasConceptScore W1880510516C54009773 @default.
• W1880510516 hasConceptScore W1880510516C55493867 @default.
• W1880510516 hasConceptScore W1880510516C59143045 @default.
• W1880510516 hasConceptScore W1880510516C82495950 @default.
• W1880510516 hasConceptScore W1880510516C86803240 @default.
• W1880510516 hasConceptScore W1880510516C90934575 @default.
• W1880510516 hasConceptScore W1880510516C95444343 @default.
• W1880510516 hasConceptScore W1880510516C97029542 @default.
• W1880510516 hasIssue "5" @default.
• W1880510516 hasLocation W18805105161 @default.
• W1880510516 hasOpenAccess W1880510516 @default.
• W1880510516 hasPrimaryLocation W18805105161 @default.
• W1880510516 hasRelatedWork W1538236582 @default.
• W1880510516 hasRelatedWork W1606195151 @default.
• W1880510516 hasRelatedWork W167860707 @default.
• W1880510516 hasRelatedWork W2005777593 @default.
• W1880510516 hasRelatedWork W2025452552 @default.
• W1880510516 hasRelatedWork W2070095498 @default.
• W1880510516 hasRelatedWork W2091066345 @default.
• W1880510516 hasRelatedWork W2110137202 @default.
• W1880510516 hasRelatedWork W2126923765 @default.
• W1880510516 hasRelatedWork W2396104867 @default.
• W1880510516 hasVolume "2" @default.
• W1880510516 isParatext "false" @default.
• W1880510516 isRetracted "false" @default.
• W1880510516 magId "1880510516" @default.

• next