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- W1880708448 abstract "IFN-induced depression is a suitable model for investigating vulnerability to depression. We aimed at investigating the role of two vulnerability factors, lifetime mood disorder (LMD) and 5-HT-related gene polymorphisms in treated patients with infection by Hepatitis C Virus (HCV).Depressive symptoms of 130 consecutive HCV patients with no current psychopathology were measured during treatment with interferon and ribavirin. At baseline, LMD and 3 genotypes (5-HTTLPR, HTR1A, and TPH2) were also assessed.Subgroups of 43 patients with LMD, 96 with HTR1A-G allele, and 12 with both LMD and HTR1A-G homozigosity scored significantly higher to depression compared to the remaining patients during antiviral therapy. At the multiple regression analysis, LMD and HTR1A-G, whether separately or combined together, explained a similar amount of 10-22% of depression score variance, after controlling for the associated variables (age and gender).HCV patients referred to a tertiary care center are not representative of all patients with chronic hepatitis C. Mediating factors, including proinflammatory cytokines and other potentially relevant gene polymorphisms, could not be evaluated. Patients were not stratified by degree of liver inflammation. LMD diagnoses were not cross-checked with medical records and IFN-induced depression was measured with a self-report scale only.History of mood disorders and HTR1A G allele variation, the C-1019G polymorphism of the transcriptional control region of the 5-HT1A receptor, independently predicted the incidence of IFN-induced depression in HCV patients, whether separately or jointly considered and although not reciprocally associated." @default.
- W1880708448 created "2016-06-24" @default.
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- W1880708448 date "2015-09-01" @default.
- W1880708448 modified "2023-10-16" @default.
- W1880708448 title "Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C" @default.
- W1880708448 cites W1838542666 @default.
- W1880708448 cites W1946192834 @default.
- W1880708448 cites W1966865235 @default.
- W1880708448 cites W1968260526 @default.
- W1880708448 cites W1973560223 @default.
- W1880708448 cites W1977300462 @default.
- W1880708448 cites W1978828287 @default.
- W1880708448 cites W1981407617 @default.
- W1880708448 cites W1982720259 @default.
- W1880708448 cites W1983553720 @default.
- W1880708448 cites W1987906603 @default.
- W1880708448 cites W1989516949 @default.
- W1880708448 cites W1990240249 @default.
- W1880708448 cites W1991617294 @default.
- W1880708448 cites W1994516975 @default.
- W1880708448 cites W1996454121 @default.
- W1880708448 cites W1997351479 @default.
- W1880708448 cites W1998220765 @default.
- W1880708448 cites W1998976706 @default.
- W1880708448 cites W1999172586 @default.
- W1880708448 cites W2002837372 @default.
- W1880708448 cites W2006969744 @default.
- W1880708448 cites W2012102163 @default.
- W1880708448 cites W2018896573 @default.
- W1880708448 cites W2023748280 @default.
- W1880708448 cites W2027545702 @default.
- W1880708448 cites W2033567930 @default.
- W1880708448 cites W2034142763 @default.
- W1880708448 cites W2035121795 @default.
- W1880708448 cites W2035663126 @default.
- W1880708448 cites W2039648711 @default.
- W1880708448 cites W2042701393 @default.
- W1880708448 cites W2047739268 @default.
- W1880708448 cites W2051743459 @default.
- W1880708448 cites W2053898109 @default.
- W1880708448 cites W2056508233 @default.
- W1880708448 cites W2058702631 @default.
- W1880708448 cites W2060329993 @default.
- W1880708448 cites W2061639643 @default.
- W1880708448 cites W2064540128 @default.
- W1880708448 cites W2065948396 @default.
- W1880708448 cites W2066901708 @default.
- W1880708448 cites W2068465151 @default.
- W1880708448 cites W2071148746 @default.
- W1880708448 cites W2073957455 @default.
- W1880708448 cites W2080812988 @default.
- W1880708448 cites W2085501514 @default.
- W1880708448 cites W2092756373 @default.
- W1880708448 cites W2100175023 @default.
- W1880708448 cites W2102134933 @default.
- W1880708448 cites W2106095564 @default.
- W1880708448 cites W2106885532 @default.
- W1880708448 cites W2109338576 @default.
- W1880708448 cites W2110654827 @default.
- W1880708448 cites W2111649281 @default.
- W1880708448 cites W2119526257 @default.
- W1880708448 cites W2121487646 @default.
- W1880708448 cites W2126795224 @default.
- W1880708448 cites W2134334380 @default.
- W1880708448 cites W2137296158 @default.
- W1880708448 cites W2139252405 @default.
- W1880708448 cites W2151007202 @default.
- W1880708448 cites W2153177038 @default.
- W1880708448 cites W2153538902 @default.
- W1880708448 cites W2153720399 @default.
- W1880708448 cites W2158089426 @default.
- W1880708448 cites W2162176738 @default.
- W1880708448 cites W2162770913 @default.
- W1880708448 cites W2164104699 @default.
- W1880708448 cites W2166281097 @default.
- W1880708448 cites W2166906023 @default.
- W1880708448 cites W2168572474 @default.
- W1880708448 cites W2169031558 @default.
- W1880708448 cites W2321458609 @default.
- W1880708448 cites W2333452860 @default.
- W1880708448 cites W2336799715 @default.
- W1880708448 doi "https://doi.org/10.1016/j.jad.2015.04.056" @default.
- W1880708448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26001668" @default.
- W1880708448 hasPublicationYear "2015" @default.
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