FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880964103> ?p ?o ?g. }

• W1880964103 endingPage "19731" @default.
• W1880964103 startingPage "19722" @default.
• W1880964103 abstract "In this investigation, we have designed and synthesized a novel core–shell polymer nanoparticle system for highly effective chemo–photothermal combination therapy. A nanoscale DSPE-PEG micelle encapsulating doxorubicin (Dox-M) was designed as a core, and then modified by a polydopamine (PDA) shell for photothermal therapy and bortezomib (Btz) administration (Dox-M@PDA–Btz). The facile conjugation of Btz to the catechol-containing PDA shell can form a reversible pH-sensitive boronic acid–catechol conjugate to create a stimuli-responsive drug carrier system. As expected, the micelle@PDA core–shell nanoparticles exhibited satisfactory photothermal efficiency, which has potential for thermal ablation of malignant tissues. In addition, on account of the PDA modification, both Dox and Btz release processes were pH-dependent and NIR-dependent. Both in vitro and in vivo studies illustrated that the Dox-M@PDA–Btz nanoparticles coupled with laser irradiation could enhance the cytotoxicity, and thus combinational therapy efficacy was achieved when integrating Dox, Btz, and PDA into a single nanoplatform. Altogether, our current study indicated that the micelle@polydopamine core–shell nanoparticles could be applied for NIR/pH-responsive sustained-release and synergized chemo–photothermal therapy for breast cancer." @default.
• W1880964103 created "2016-06-24" @default.
• W1880964103 creator A5021338086 @default.
• W1880964103 creator A5024447850 @default.
• W1880964103 creator A5041509508 @default.
• W1880964103 creator A5063034183 @default.
• W1880964103 creator A5067339985 @default.
• W1880964103 creator A5076857313 @default.
• W1880964103 creator A5088213348 @default.
• W1880964103 date "2015-01-01" @default.
• W1880964103 modified "2023-10-04" @default.
• W1880964103 title "Smart micelle@polydopamine core–shell nanoparticles for highly effective chemo–photothermal combination therapy" @default.
• W1880964103 cites W1967604695 @default.
• W1880964103 cites W1979488641 @default.
• W1880964103 cites W1981387651 @default.
• W1880964103 cites W1994023367 @default.
• W1880964103 cites W1998526411 @default.
• W1880964103 cites W1999313400 @default.
• W1880964103 cites W2006626083 @default.
• W1880964103 cites W2009598580 @default.
• W1880964103 cites W2017290810 @default.
• W1880964103 cites W2027669232 @default.
• W1880964103 cites W2032602686 @default.
• W1880964103 cites W2033905916 @default.
• W1880964103 cites W2034105791 @default.
• W1880964103 cites W2034913332 @default.
• W1880964103 cites W2043385261 @default.
• W1880964103 cites W2047358259 @default.
• W1880964103 cites W2048225778 @default.
• W1880964103 cites W2071058847 @default.
• W1880964103 cites W2083961389 @default.
• W1880964103 cites W2092319622 @default.
• W1880964103 cites W2118291545 @default.
• W1880964103 cites W2127688249 @default.
• W1880964103 cites W2136502605 @default.
• W1880964103 cites W2143024460 @default.
• W1880964103 cites W2146378598 @default.
• W1880964103 cites W2153409108 @default.
• W1880964103 cites W2155203762 @default.
• W1880964103 cites W2169829820 @default.
• W1880964103 cites W2316291164 @default.
• W1880964103 cites W2322562148 @default.
• W1880964103 cites W2328886593 @default.
• W1880964103 cites W2330246146 @default.
• W1880964103 cites W2335405043 @default.
• W1880964103 doi "https://doi.org/10.1039/c5nr04828a" @default.
• W1880964103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26556382" @default.
• W1880964103 hasPublicationYear "2015" @default.
• W1880964103 type Work @default.
• W1880964103 sameAs 1880964103 @default.
• W1880964103 citedByCount "93" @default.
• W1880964103 countsByYear W18809641032016 @default.
• W1880964103 countsByYear W18809641032017 @default.
• W1880964103 countsByYear W18809641032018 @default.
• W1880964103 countsByYear W18809641032019 @default.
• W1880964103 countsByYear W18809641032020 @default.
• W1880964103 countsByYear W18809641032021 @default.
• W1880964103 countsByYear W18809641032022 @default.
• W1880964103 countsByYear W18809641032023 @default.
• W1880964103 crossrefType "journal-article" @default.
• W1880964103 hasAuthorship W1880964103A5021338086 @default.
• W1880964103 hasAuthorship W1880964103A5024447850 @default.
• W1880964103 hasAuthorship W1880964103A5041509508 @default.
• W1880964103 hasAuthorship W1880964103A5063034183 @default.
• W1880964103 hasAuthorship W1880964103A5067339985 @default.
• W1880964103 hasAuthorship W1880964103A5076857313 @default.
• W1880964103 hasAuthorship W1880964103A5088213348 @default.
• W1880964103 hasConcept C11268172 @default.
• W1880964103 hasConcept C12554922 @default.
• W1880964103 hasConcept C134306372 @default.
• W1880964103 hasConcept C141071460 @default.
• W1880964103 hasConcept C15083742 @default.
• W1880964103 hasConcept C150903083 @default.
• W1880964103 hasConcept C155672457 @default.
• W1880964103 hasConcept C171250308 @default.
• W1880964103 hasConcept C178790620 @default.
• W1880964103 hasConcept C182606246 @default.
• W1880964103 hasConcept C184651966 @default.
• W1880964103 hasConcept C185592680 @default.
• W1880964103 hasConcept C192562407 @default.
• W1880964103 hasConcept C197336794 @default.
• W1880964103 hasConcept C207001950 @default.
• W1880964103 hasConcept C21951064 @default.
• W1880964103 hasConcept C2776694085 @default.
• W1880964103 hasConcept C2779820397 @default.
• W1880964103 hasConcept C2781303535 @default.
• W1880964103 hasConcept C33923547 @default.
• W1880964103 hasConcept C71924100 @default.
• W1880964103 hasConcept C86803240 @default.
• W1880964103 hasConceptScore W1880964103C11268172 @default.
• W1880964103 hasConceptScore W1880964103C12554922 @default.
• W1880964103 hasConceptScore W1880964103C134306372 @default.
• W1880964103 hasConceptScore W1880964103C141071460 @default.
• W1880964103 hasConceptScore W1880964103C15083742 @default.
• W1880964103 hasConceptScore W1880964103C150903083 @default.
• W1880964103 hasConceptScore W1880964103C155672457 @default.
• W1880964103 hasConceptScore W1880964103C171250308 @default.
• W1880964103 hasConceptScore W1880964103C178790620 @default.

• next