FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1880979330> ?p ?o ?g. }

• W1880979330 endingPage "2586" @default.
• W1880979330 startingPage "2575" @default.
• W1880979330 abstract "Cyclophosphamide (CY) is a chemotherapeutic agent used for cancer and immunological diseases. It induces cytotoxicity of bone marrow and causes myelosuppression and extramedullary haematopoiesis (EMH) in treated patients. EMH is characterized with the emergence of multipotent haematopoietic progenitors most likely in the spleen and liver. Previous studies indicated that a Chinese medicine, ginsenoside Rg1, confers a significant effect to elevate the number of lineage (Lin(-) ) Sca-1(+) c-Kit(+) haematopoietic stem and progenitor cells (HSPCs) and restore the function of bone marrow in CY-treated myelosuppressed mice. However, whether the amelioration of bone marrow by Rg1 accompanies an alleviation of EMH in the spleen was still unknown. In our study, the cellularity and weight of the spleen were significantly reduced after Rg1 treatment in CY-treated mice. Moreover, the number of c-Kit(+) HSPCs was significantly decreased but not as a result of apoptosis, indicating that Rg1 alleviated EMH of the spleen induced by CY. Unexpectedly, the proliferation activity of c-Kit(+) HSPCs was only up-regulated in the spleen, but not in the bone marrow, after Rg1 treatment in CY-treated mice. We also found that a fraction of c-Kit(+) /CD45(+) HSPCs was simultaneously increased in the circulation after Rg1 treatment. Interestingly, the effects of Rg1 on the elevation of HSPCs in bone marrow and in the peripheral blood were suppressed in CY-treated splenectomized mice. These results demonstrated that Rg1 improves myelosuppression induced by CY through its action on the proliferation of HSPCs in EMH of the spleen and migration of HSPCs from the spleen to the bone marrow." @default.
• W1880979330 created "2016-06-24" @default.
• W1880979330 creator A5021483693 @default.
• W1880979330 creator A5035182356 @default.
• W1880979330 creator A5052268785 @default.
• W1880979330 creator A5059434374 @default.
• W1880979330 creator A5088965969 @default.
• W1880979330 date "2015-07-08" @default.
• W1880979330 modified "2023-10-14" @default.
• W1880979330 title "Ginsenoside Rg1 improves bone marrow haematopoietic activity <i>via</i> extramedullary haematopoiesis of the spleen" @default.
• W1880979330 cites W1880161049 @default.
• W1880979330 cites W194965259 @default.
• W1880979330 cites W1965858907 @default.
• W1880979330 cites W1966991424 @default.
• W1880979330 cites W1967453876 @default.
• W1880979330 cites W1968451357 @default.
• W1880979330 cites W1968961892 @default.
• W1880979330 cites W1970909450 @default.
• W1880979330 cites W1972384996 @default.
• W1880979330 cites W1977420876 @default.
• W1880979330 cites W1982049416 @default.
• W1880979330 cites W1984785779 @default.
• W1880979330 cites W1986109021 @default.
• W1880979330 cites W1987633541 @default.
• W1880979330 cites W1989721541 @default.
• W1880979330 cites W1993564004 @default.
• W1880979330 cites W1998794592 @default.
• W1880979330 cites W1999132647 @default.
• W1880979330 cites W2004814040 @default.
• W1880979330 cites W2004838691 @default.
• W1880979330 cites W2007567046 @default.
• W1880979330 cites W2007800687 @default.
• W1880979330 cites W2018519613 @default.
• W1880979330 cites W2021312689 @default.
• W1880979330 cites W2023543357 @default.
• W1880979330 cites W2025019998 @default.
• W1880979330 cites W2028081801 @default.
• W1880979330 cites W2032936777 @default.
• W1880979330 cites W2040169521 @default.
• W1880979330 cites W2045709102 @default.
• W1880979330 cites W2052503698 @default.
• W1880979330 cites W2054574471 @default.
• W1880979330 cites W2057458384 @default.
• W1880979330 cites W2073895217 @default.
• W1880979330 cites W2074777297 @default.
• W1880979330 cites W2081537178 @default.
• W1880979330 cites W2096224929 @default.
• W1880979330 cites W2104479081 @default.
• W1880979330 cites W2108401821 @default.
• W1880979330 cites W2109381868 @default.
• W1880979330 cites W2126665281 @default.
• W1880979330 cites W2134939252 @default.
• W1880979330 cites W2141593635 @default.
• W1880979330 cites W2144456609 @default.
• W1880979330 cites W2159913536 @default.
• W1880979330 cites W2163355013 @default.
• W1880979330 cites W2168826120 @default.
• W1880979330 cites W2170969735 @default.
• W1880979330 cites W3149553072 @default.
• W1880979330 doi "https://doi.org/10.1111/jcmm.12643" @default.
• W1880979330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627563" @default.
• W1880979330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26153045" @default.
• W1880979330 hasPublicationYear "2015" @default.
• W1880979330 type Work @default.
• W1880979330 sameAs 1880979330 @default.
• W1880979330 citedByCount "14" @default.
• W1880979330 countsByYear W18809793302017 @default.
• W1880979330 countsByYear W18809793302020 @default.
• W1880979330 countsByYear W18809793302021 @default.
• W1880979330 countsByYear W18809793302022 @default.
• W1880979330 countsByYear W18809793302023 @default.
• W1880979330 crossrefType "journal-article" @default.
• W1880979330 hasAuthorship W1880979330A5021483693 @default.
• W1880979330 hasAuthorship W1880979330A5035182356 @default.
• W1880979330 hasAuthorship W1880979330A5052268785 @default.
• W1880979330 hasAuthorship W1880979330A5059434374 @default.
• W1880979330 hasAuthorship W1880979330A5088965969 @default.
• W1880979330 hasBestOaLocation W18809793301 @default.
• W1880979330 hasConcept C109159458 @default.
• W1880979330 hasConcept C126322002 @default.
• W1880979330 hasConcept C201750760 @default.
• W1880979330 hasConcept C203014093 @default.
• W1880979330 hasConcept C2776694085 @default.
• W1880979330 hasConcept C2776755627 @default.
• W1880979330 hasConcept C2778080410 @default.
• W1880979330 hasConcept C2780007613 @default.
• W1880979330 hasConcept C2780931953 @default.
• W1880979330 hasConcept C28328180 @default.
• W1880979330 hasConcept C502942594 @default.
• W1880979330 hasConcept C71924100 @default.
• W1880979330 hasConcept C86803240 @default.
• W1880979330 hasConcept C95444343 @default.
• W1880979330 hasConceptScore W1880979330C109159458 @default.
• W1880979330 hasConceptScore W1880979330C126322002 @default.
• W1880979330 hasConceptScore W1880979330C201750760 @default.
• W1880979330 hasConceptScore W1880979330C203014093 @default.
• W1880979330 hasConceptScore W1880979330C2776694085 @default.
• W1880979330 hasConceptScore W1880979330C2776755627 @default.

• next