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- W1881021617 endingPage "e1005166" @default.
- W1881021617 startingPage "e1005166" @default.
- W1881021617 abstract "Mouse polyomavirus (MPyV) lytically infects mouse cells, transforms rat cells in culture, and is highly oncogenic in rodents. We have used deep sequencing to follow MPyV infection of mouse NIH3T6 cells at various times after infection and analyzed both the viral and cellular transcriptomes. Alignment of sequencing reads to the viral genome illustrated the transcriptional profile of the early-to-late switch with both early-strand and late-strand RNAs being transcribed at all time points. A number of novel insights into viral gene expression emerged from these studies, including the demonstration of widespread RNA editing of viral transcripts at late times in infection. By late times in infection, 359 host genes were seen to be significantly upregulated and 857 were downregulated. Gene ontology analysis indicated transcripts involved in translation, metabolism, RNA processing, DNA methylation, and protein turnover were upregulated while transcripts involved in extracellular adhesion, cytoskeleton, zinc finger binding, SH3 domain, and GTPase activation were downregulated. The levels of a number of long noncoding RNAs were also altered. The long noncoding RNA MALAT1, which is involved in splicing speckles and used as a marker in many late-stage cancers, was noticeably downregulated, while several other abundant noncoding RNAs were strongly upregulated. We discuss these results in light of what is currently known about the MPyV life cycle and its effects on host cell growth and metabolism." @default.
- W1881021617 created "2016-06-24" @default.
- W1881021617 creator A5011788125 @default.
- W1881021617 creator A5016806740 @default.
- W1881021617 creator A5035971896 @default.
- W1881021617 creator A5088753215 @default.
- W1881021617 date "2015-09-25" @default.
- W1881021617 modified "2023-09-27" @default.
- W1881021617 title "Global Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA Editing" @default.
- W1881021617 cites W1528169973 @default.
- W1881021617 cites W1538167629 @default.
- W1881021617 cites W1549909181 @default.
- W1881021617 cites W1556062727 @default.
- W1881021617 cites W1564869014 @default.
- W1881021617 cites W1574485107 @default.
- W1881021617 cites W1595409486 @default.
- W1881021617 cites W1839915100 @default.
- W1881021617 cites W1867304165 @default.
- W1881021617 cites W1871798971 @default.
- W1881021617 cites W1878535762 @default.
- W1881021617 cites W1884928119 @default.
- W1881021617 cites W1888312006 @default.
- W1881021617 cites W1943900735 @default.
- W1881021617 cites W1963714657 @default.
- W1881021617 cites W1965355917 @default.
- W1881021617 cites W1969219687 @default.
- W1881021617 cites W1969331585 @default.
- W1881021617 cites W1973165428 @default.
- W1881021617 cites W1977064370 @default.
- W1881021617 cites W1981042913 @default.
- W1881021617 cites W1984361597 @default.
- W1881021617 cites W1985187767 @default.
- W1881021617 cites W1986679685 @default.
- W1881021617 cites W1987965896 @default.
- W1881021617 cites W1989574648 @default.
- W1881021617 cites W199182958 @default.
- W1881021617 cites W1994219871 @default.
- W1881021617 cites W1994331767 @default.
- W1881021617 cites W1998279906 @default.
- W1881021617 cites W2005002216 @default.
- W1881021617 cites W2010601729 @default.
- W1881021617 cites W2011844896 @default.
- W1881021617 cites W2013039688 @default.
- W1881021617 cites W2016876473 @default.
- W1881021617 cites W2021184394 @default.
- W1881021617 cites W2026466875 @default.
- W1881021617 cites W2035835036 @default.
- W1881021617 cites W2039095486 @default.
- W1881021617 cites W2040839903 @default.
- W1881021617 cites W2042745391 @default.
- W1881021617 cites W2044745847 @default.
- W1881021617 cites W2045756360 @default.
- W1881021617 cites W2047071723 @default.
- W1881021617 cites W2051159020 @default.
- W1881021617 cites W2055348787 @default.
- W1881021617 cites W2055632024 @default.
- W1881021617 cites W2056497285 @default.
- W1881021617 cites W2059300607 @default.
- W1881021617 cites W2060580646 @default.
- W1881021617 cites W2061882797 @default.
- W1881021617 cites W2061968489 @default.
- W1881021617 cites W2062608816 @default.
- W1881021617 cites W2067976846 @default.
- W1881021617 cites W2079093296 @default.
- W1881021617 cites W2081873181 @default.
- W1881021617 cites W2082786333 @default.
- W1881021617 cites W2083187335 @default.
- W1881021617 cites W2083700889 @default.
- W1881021617 cites W20888715 @default.
- W1881021617 cites W2094057543 @default.
- W1881021617 cites W2098085059 @default.
- W1881021617 cites W2100984579 @default.
- W1881021617 cites W2101617416 @default.
- W1881021617 cites W2102073378 @default.
- W1881021617 cites W2102649989 @default.
- W1881021617 cites W2104696769 @default.
- W1881021617 cites W2108907539 @default.
- W1881021617 cites W2116221195 @default.
- W1881021617 cites W2119518116 @default.
- W1881021617 cites W2119806797 @default.
- W1881021617 cites W2120829351 @default.
- W1881021617 cites W2124109619 @default.
- W1881021617 cites W2124463210 @default.
- W1881021617 cites W2128272932 @default.
- W1881021617 cites W2128619556 @default.
- W1881021617 cites W2132143924 @default.
- W1881021617 cites W2132881158 @default.
- W1881021617 cites W2144309286 @default.
- W1881021617 cites W2150205491 @default.
- W1881021617 cites W2154109112 @default.
- W1881021617 cites W2163457676 @default.
- W1881021617 cites W2167885135 @default.
- W1881021617 cites W2169297347 @default.
- W1881021617 cites W2315222937 @default.
- W1881021617 cites W2476542314 @default.
- W1881021617 cites W4235459495 @default.
- W1881021617 doi "https://doi.org/10.1371/journal.ppat.1005166" @default.
- W1881021617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4583464" @default.