Matches in SemOpenAlex for { <https://semopenalex.org/work/W1881457572> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1881457572 endingPage "759" @default.
- W1881457572 startingPage "755" @default.
- W1881457572 abstract "The dissociation constants for the carboxyl group of a series of glycine (N-acyl)-conjugated and unconjugated bile acids were determined by potentiometric titration using dimethylsulfoxide-water and methanol-water mixtures of varying proportions. The pKa values in water were calculated by extrapolating the experimental values determined in different mole fractions of the organic solvent mixtures. The following values were obtained: 3.9 +/- 0.1 for glycine-conjugated bile acids and 5.0 +/- 0.1 for unconjugated bile acids, as general pKa values for the two classes of bile acids, respectively. The amidation of bile acids with glycine lowers the pKa value because of the proximity of the amide bond to the terminal carboxyl group. Bile acid dissociation constants are independent of the substituents in the steroid nucleus, since inductive effects of the hydroxyl groups on the steroid nucleus are too distant from the acidic group at the end of the side chain to influence its ionization." @default.
- W1881457572 created "2016-06-24" @default.
- W1881457572 creator A5000717146 @default.
- W1881457572 creator A5033420164 @default.
- W1881457572 date "1987-07-01" @default.
- W1881457572 modified "2023-09-27" @default.
- W1881457572 title "Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids." @default.
- W1881457572 cites W1564906832 @default.
- W1881457572 cites W1973335911 @default.
- W1881457572 cites W1992564377 @default.
- W1881457572 cites W2002007907 @default.
- W1881457572 cites W2020205531 @default.
- W1881457572 cites W2026630616 @default.
- W1881457572 cites W2056428612 @default.
- W1881457572 cites W2062041048 @default.
- W1881457572 cites W2062395695 @default.
- W1881457572 cites W2073653294 @default.
- W1881457572 cites W2093256451 @default.
- W1881457572 cites W2146017274 @default.
- W1881457572 cites W2149483752 @default.
- W1881457572 cites W2152949393 @default.
- W1881457572 cites W2171755074 @default.
- W1881457572 cites W2338183850 @default.
- W1881457572 doi "https://doi.org/10.1016/s0022-2275(20)38646-6" @default.
- W1881457572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3625035" @default.
- W1881457572 hasPublicationYear "1987" @default.
- W1881457572 type Work @default.
- W1881457572 sameAs 1881457572 @default.
- W1881457572 citedByCount "82" @default.
- W1881457572 countsByYear W18814575722012 @default.
- W1881457572 countsByYear W18814575722013 @default.
- W1881457572 countsByYear W18814575722014 @default.
- W1881457572 countsByYear W18814575722015 @default.
- W1881457572 countsByYear W18814575722016 @default.
- W1881457572 countsByYear W18814575722017 @default.
- W1881457572 countsByYear W18814575722018 @default.
- W1881457572 countsByYear W18814575722019 @default.
- W1881457572 countsByYear W18814575722020 @default.
- W1881457572 countsByYear W18814575722021 @default.
- W1881457572 countsByYear W18814575722022 @default.
- W1881457572 countsByYear W18814575722023 @default.
- W1881457572 crossrefType "journal-article" @default.
- W1881457572 hasAuthorship W1881457572A5000717146 @default.
- W1881457572 hasAuthorship W1881457572A5033420164 @default.
- W1881457572 hasBestOaLocation W18814575721 @default.
- W1881457572 hasConcept C112613896 @default.
- W1881457572 hasConcept C178790620 @default.
- W1881457572 hasConcept C185592680 @default.
- W1881457572 hasConcept C2777756961 @default.
- W1881457572 hasConcept C2779399885 @default.
- W1881457572 hasConcept C515207424 @default.
- W1881457572 hasConcept C521977710 @default.
- W1881457572 hasConcept C55493867 @default.
- W1881457572 hasConceptScore W1881457572C112613896 @default.
- W1881457572 hasConceptScore W1881457572C178790620 @default.
- W1881457572 hasConceptScore W1881457572C185592680 @default.
- W1881457572 hasConceptScore W1881457572C2777756961 @default.
- W1881457572 hasConceptScore W1881457572C2779399885 @default.
- W1881457572 hasConceptScore W1881457572C515207424 @default.
- W1881457572 hasConceptScore W1881457572C521977710 @default.
- W1881457572 hasConceptScore W1881457572C55493867 @default.
- W1881457572 hasIssue "7" @default.
- W1881457572 hasLocation W18814575721 @default.
- W1881457572 hasLocation W18814575722 @default.
- W1881457572 hasOpenAccess W1881457572 @default.
- W1881457572 hasPrimaryLocation W18814575721 @default.
- W1881457572 hasRelatedWork W1590993351 @default.
- W1881457572 hasRelatedWork W1966796527 @default.
- W1881457572 hasRelatedWork W2040249061 @default.
- W1881457572 hasRelatedWork W2041846912 @default.
- W1881457572 hasRelatedWork W2044257351 @default.
- W1881457572 hasRelatedWork W2085346965 @default.
- W1881457572 hasRelatedWork W2094611941 @default.
- W1881457572 hasRelatedWork W2326955759 @default.
- W1881457572 hasRelatedWork W2346698954 @default.
- W1881457572 hasRelatedWork W2952305790 @default.
- W1881457572 hasVolume "28" @default.
- W1881457572 isParatext "false" @default.
- W1881457572 isRetracted "false" @default.
- W1881457572 magId "1881457572" @default.
- W1881457572 workType "article" @default.